Trends in the prevalence, incidence and survival of non-Hodgkin lymphoma subtypes during the 21st century - a Swedish lymphoma register study

Non-Hodgkin lymphoma (NHL) prognosis has improved in recent years, yet the number of patients living with the diagnosis, i.e. the prevalence, has seldom been reported. The prevalence provides a measure of the burden of disease, useful for healthcare planning and to optimise resource allocation. We provide a systematic presentation of temporal trends in absolute numbers of prevalent patients by NHL subtypes, linking them to trends in incidence, survival and mortality. Patients diagnosed 2000-2016 were identified in the national Swedish lymphoma register. Incidence and mortality rates, relative survival and prevalence were estimated for NHL overall and for major clinical and morphological subtypes. Poisson regression was used to test for temporal trends. Increasing incidence and improved survival have led to a 47% increase in the five-year prevalence of NHL overall in 2016 compared to 2004. An increasing prevalence was observed for all investigated subtypes during the study period, but most notably for diffuse large B cell lymphomas among aggressive subtypes (66%), and marginal zone lymphomas among indolent subtypes (135%). This dramatic increase in NHL prevalence underscores the need to develop and evaluate alternative follow-up schemes to use resources efficiently and still ensure optimal care of lymphoma survivors.

Smedby, KarinKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (author)
Glimelius, Ingrid,1975-Karolinska Institutet,Uppsala University,Karolinska Institute,Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Med Solna, Div Clin Epidemiol, Stockholm, Sweden(Swepub:uu)inggl846 (author)
Nilsson-Ehle, Herman,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xnilsh (author)
Goldkuhl, ChristinaSahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.,Sahlgrenska University Hospital (author)
Lewerin, Catharina,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xlewca (author)
Jerkeman, MatsLund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-mje (author)
Eloranta, SandraKarolinska Institutet,Karolinska Institute (author)
Karolinska InstitutetKarolinska Institute (creator_code:org_t)

By the author/editor: Ekberg, Sara; Smedby, Karin; Glimelius, Ingri ...; Nilsson-Ehle, He ...; Goldkuhl, Christ ...; Lewerin, Cathari ...; show more...; Jerkeman, Mats; Eloranta, Sandra; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

By the university: Uppsala University; Lund University; Karolinska Institutet; University of Gothenburg

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