Sökning: WFRF:(Majhail Navneet) >
Outcomes of rituxim...
Outcomes of rituximab‐BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation
-
- Jagadeesh, Deepa (författare)
- Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA.
-
- Majhail, Navneet S. (författare)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
-
- He, Yizeng (författare)
- Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA.
-
visa fler...
-
- Ahn, Kwang W. (författare)
- Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
-
- Litovich, Carlos (författare)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
-
- Ahmed, Sairah (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
-
- Aljurf, Mahmoud (författare)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
-
- Bacher, Ulrike (författare)
- Univ Bern, Bern Univ Hosp, Inselspital, Dept Hematol, Bern, Switzerland.
-
- Badawy, Sherif M. (författare)
- Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
-
- Bejanyan, Nelli (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
-
- Cairo, Mitchell (författare)
- New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.;Ohio State Univ, Dept Med, James Canc Hosp, Div Hematol, Columbus, OH 43210 USA.
-
- Cerny, Jan (författare)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
-
- Epperla, Narendranath (författare)
- Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA.
-
- Farhadfar, Nosha (författare)
- Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.
-
- Freytes, Cesar O. (författare)
- Texas Transplant Inst, San Antonio, TX USA.
-
- Gale, Robert Peter (författare)
- Imperial Coll London, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
-
- Haverkos, Bradley (författare)
- Univ Colorado Hosp, Aurora, CO USA.
-
- Hossain, Nasheed (författare)
- Loyola Univ, Chicago Stritch Sch Med, Dept Med, Stem Cell Transplant Program,Div Hematol Oncol, Maywood, IL 60153 USA.
-
- Inwards, David (författare)
- Mayo Clin, Div Hematol, Rochester, MN USA.
-
- Kamble, Rammurti T. (författare)
- Baylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA.
-
- Kenkre, Vaishalee P. (författare)
- Univ Wisconsin, Div Hematol Oncol, Madison, WI USA.
-
- Lazarus, Hillard M. (författare)
- Case Western Reserve Univ, Div Hematol Oncol, Cleveland, OH 44106 USA.
-
- Lazaryan, Aleksandr (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
-
- Lekakis, Lazaros (författare)
- Univ Miami, Dept Hematol Oncol, Miami, FL USA.
-
- Mei, Matthew (författare)
- City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.
-
- Murthy, Hemant S. (författare)
- Mayo Clin Florida, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.
-
- Mussetti, Alberto (författare)
- Inst Catala Oncol Hosp, Dept Hematol, Barcelona, Spain.;IDIBELL Inst Catala Oncol, Lhospitalet De Llobregat, El Prat De Llob, Spain.
-
- Nathan, Sunita (författare)
- Rush Univ, Div Hematol Oncol & Cell Therapy, Med Ctr, Chicago, IL 60612 USA.
-
- Nishihori, Taiga (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
-
- Olsson, Richard (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
-
- Geethakumari, Praveen Ramakrishnan (författare)
- Univ Texas Southwestern Med Ctr, Lymphoma BMT & Cellular Therapy Program, Dallas, TX USA.
-
- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
-
- Yared, Jean A. (författare)
- Univ Maryland, Dept Med, Blood & Marrow Transplantat Program, Greenebaum Comprehens Canc Ctr,Div Hematol Oncol, Baltimore, MD 21201 USA.
-
- Fenske, Timothy S. (författare)
- Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
-
- Kharfan-Dabaja, Mohamed A. (författare)
- Mayo Clin Florida, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.
-
- Sureda, Anna (författare)
- Inst Catala Oncol Hosp, Dept Hematol, Barcelona, Spain.;IDIBELL Inst Catala Oncol, Lhospitalet De Llobregat, El Prat De Llob, Spain.
-
- Hamadani, Mehdi (författare)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
-
visa färre...
-
Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA. (creator_code:org_t)
- 2020-02-12
- 2020
- Engelska.
-
Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 126:10, s. 2279-2287
- Relaterad länk:
-
https://acsjournals....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND Although rituximab-based high-dose therapy is frequently used in diffuse large B cell lymphoma (DLBCL) patients undergoing autologous hematopoietic cell transplantation (auto-HCT), data supporting the benefits are not available. Herein, we report the impact of rituximab-based conditioning on auto-HCT outcomes in patients who have DLBCL. METHODS Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, 862 adult DLBCL patients undergoing auto-HCT between 2003 and 2017 using BEAM (BCNU, etoposide, cytarabine, melphalan) conditioning regimen were included. All patients received frontline rituximab-containing chemoimmunotherapy and had chemosensitive disease pre-HCT. Early chemoimmunotherapy failure was defined as not achieving complete remission (CR) after frontline chemoimmunotherapy or relapse within 1 year of initial diagnosis. The primary outcome was overall survival (OS). RESULTS The study cohort was divided into 2 groups: BEAM (n = 667) and R-BEAM (n = 195). On multivariate analysis, no significant difference was seen in OS (P = .83) or progression-free survival (PFS) (P = .61) across the 2 cohorts. No significant association between the use of rituximab and risk of relapse (P = .15) or nonrelapse mortality (P = .12) was observed. Variables independently associated with lower OS included older age at auto-HCT (P < .001), absence of CR at auto-HCT (P < .001) and early chemoimmunotherapy failure (P < .001). Older age (P < .0002) and non-CR pre-HCT (P < .0001) were also associated with inferior PFS. There was no significant difference in early infectious complications between the 2 cohorts. CONCLUSION In this large registry analysis of DLBCL patients undergoing auto-HCT, the addition of rituximab to the BEAM conditioning regimen had no impact on transplantation outcomes. Older age, absence of CR pre auto-HCT, and early chemoimmunotherapy failure were associated with inferior survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- autologous transplantation
- BEAM
- chemoimmunotherapy
- diffuse large B cell lymphoma
- rituximab
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Cancer
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Jagadeesh, Deepa
-
Majhail, Navneet ...
-
He, Yizeng
-
Ahn, Kwang W.
-
Litovich, Carlos
-
Ahmed, Sairah
-
visa fler...
-
Aljurf, Mahmoud
-
Bacher, Ulrike
-
Badawy, Sherif M ...
-
Bejanyan, Nelli
-
Cairo, Mitchell
-
Cerny, Jan
-
Epperla, Narendr ...
-
Farhadfar, Nosha
-
Freytes, Cesar O ...
-
Gale, Robert Pet ...
-
Haverkos, Bradle ...
-
Hossain, Nasheed
-
Inwards, David
-
Kamble, Rammurti ...
-
Kenkre, Vaishale ...
-
Lazarus, Hillard ...
-
Lazaryan, Aleksa ...
-
Lekakis, Lazaros
-
Mei, Matthew
-
Murthy, Hemant S ...
-
Mussetti, Albert ...
-
Nathan, Sunita
-
Nishihori, Taiga
-
Olsson, Richard
-
Geethakumari, Pr ...
-
Savani, Bipin N.
-
Yared, Jean A.
-
Fenske, Timothy ...
-
Kharfan-Dabaja, ...
-
Sureda, Anna
-
Hamadani, Mehdi
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Cancer
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet