Threshold-automated CT measurements of muscle size and radiological attenuation in multiple lower-extremity muscles of older individuals

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Berg, Hans E.Karolinska Institutet (author)

Threshold-automated CT measurements of muscle size and radiological attenuation in multiple lower-extremity muscles of older individuals

Article/chapterEnglish2020

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WILEY,2020
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LIBRIS-ID:oai:DiVA.org:uu-425115
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425115URI
https://doi.org/10.1111/cpf.12618DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:142865317URI

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Language:English
Summary in:English

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Muscle atrophy and fat infiltration, two indicators of deconditioning and weakness in elderly frail patients, are typically assessed by means of manual image analysis from computed tomography (CT) scans. As this time-consuming image analysis limits its wider use in clinical studies, the use of tissue thresholds to semi-automatically assess muscle composition has been suggested. Here, we aimed to investigate the relationship between manual and semi-automated analysis of both cross-sectional area (CSA) and radiological attenuation (RA), in multiple muscles of the lower extremities in aged (77 +/- 6 years) sedentary individuals (n = 40). The participants underwent CT scans of their lower limbs, including hip, thigh and calf muscles. The subsequent analysis of CSA and RA was conducted using both manual segmentation and semi-automatic thresholds (-30 to +150 Hounsfield units). Automated measurements were generally strongly correlated with manually encircled CSA in all muscle groups (R = 0.79-0.99, p < .05) and shortened the analysis time by 70% (p < .05). In m. iliopsoas, however, the CSA became overestimated (15%, p < .05) with thresholded measurements, while the assessment of both CSA and RA was underestimated in muscles with high-fat content (i.e., the gluteal muscles) and in individuals with high-fat infiltration. In conclusion, using the semi-automated technique with conventional thresholds is a time-saving method that delivers accurate gross size of the muscle groups, particularly in the thigh. However, caution should be exercised when using semi-automated techniques for assessing CSA and fat infiltration in muscles with high-fat content.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
computed tomography
fat infiltration
hounsfield units
muscle atrophy
sarcopenia
skeletal muscle

Added entries (persons, corporate bodies, meetings, titles ...)

Truong, DanielKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Orthopaed Surg, SE-14186 Stockholm, Sweden. (author)
Skoglund, ElisabethKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Karolinska Inst, Div Clin Physiol, Dept Lab Med, Stockholm, Sweden.;Karolinska Univ Hosp, Unit Clin Physiol, Stockholm, Sweden.(Swepub:uu)elibe194 (author)
Gustafsson, ThomasKarolinska Institutet (author)
Lundberg, Tommy R.Karolinska Institutet (author)
Karolinska InstitutetKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Orthopaed Surg, SE-14186 Stockholm, Sweden. (creator_code:org_t)

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In:Clinical Physiology and Functional Imaging: WILEY40:3, s. 165-1721475-09611475-097X

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By the author/editor: Berg, Hans E.; Truong, Daniel; Skoglund, Elisab ...; Gustafsson, Thom ...; Lundberg, Tommy ...

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