(WFRF:(Elosua Roberto)) srt2:(2020-2023)
Sökning: (WFRF:(Elosua Roberto)) srt2:(2020-2023) > High-density lipopr...
High-density lipoprotein characteristics and coronary artery disease : a Mendelian randomization study
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- Prats-Uribe, Albert (författare)
- Hosp del Mar Med Res Inst IMIM, Cardiovasc Epidemiol & Genet Res Grp, Carrer Doctor Aiguader 88, Barcelona 08003, Spain.;Univ Pompeu Fabra, Prevent Med & Publ Hlth Unit, ISGLOBAL, Parc Salut Mar, Barcelona, Spain.;Univ Oxford, Ctr Stat Med, Botnar Res Ctr, NDORMS, Oxford, England.
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- Sayols-Baixeras, Sergi (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Hosp del Mar Med Res Inst IMIM, Cardiovasc Epidemiol & Genet Res Grp, Carrer Doctor Aiguader 88, Barcelona 08003, Spain.;Univ Pompeu Fabra, Campus Mar, Barcelona, Spain.;Inst Salud Carlos III, MP Enfermedades Cardiovasc CIBERCV, Consorcio CIBER, Madrid, Spain.
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- Fernandez-Sanles, Alba (författare)
- Hosp del Mar Med Res Inst IMIM, Cardiovasc Epidemiol & Genet Res Grp, Carrer Doctor Aiguader 88, Barcelona 08003, Spain.;Univ Pompeu Fabra, Campus Mar, Barcelona, Spain.;Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Bristol, Avon, England.
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- Hosp del Mar Med Res Inst IMIM, Cardiovasc Epidemiol & Genet Res Grp, Carrer Doctor Aiguader 88, Barcelona 08003, Spain;Univ Pompeu Fabra, Prevent Med & Publ Hlth Unit, ISGLOBAL, Parc Salut Mar, Barcelona, Spain.;Univ Oxford, Ctr Stat Med, Botnar Res Ctr, NDORMS, Oxford, England. Molekylär epidemiologi (creator_code:org_t)
- W B SAUNDERS CO-ELSEVIER INC, 2020
- 2020
- Engelska.
- Ingår i: Metabolism. - : W B SAUNDERS CO-ELSEVIER INC. - 0026-0495 .- 1532-8600. ; 112
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). Methods: We designed a two-sample multivariate Mendelian randomization study with available genome-wide association summary data. We identified genetic variants associated with HDL cholesterol and apolipoprotein A-I levels, HDL size, particle levels, and lipid content to define our genetic instrumental variables in one sample (Kettunen et al. study, n = 24,925) and analyzed their association with CAD risk in a different study (CARDloGRAMplusC4D, n = 184,305). We validated these results by defining our genetic variables in another database (METSINI, n = 8372) and studied their relationship with CAD in the CARDloGRAMplusC4D dataset. To estimate the effect size of the associations of interest adjusted for other lipoprotein traits and minimize potential pleiotropy, we used the Multi-trait-based Conditional & Joint analysis. Results: Genetically determined HDL cholesterol and apolipoprotein A-I levels were not associated with CAD. HDL mean diameter (beta = 027 [95%CI = 0.19; 0.35]), cholesterol levels in very large HDLs (beta = 0.29 (95%CI = 0.17; 0.40]), and triglyceride content in very large HDIs (beta = 0.14 [95%CI = 0.040; 025]) were directly associated with CAD risk, whereas the cholesterol content in medium-sized HDLs (beta = -0.076 [95%CI = -0.10; -0.052]) was inversely related to this risk. These results were validated in the METSIM-CARDloGRAMplu5C4D data. Conclusions: Some qualitative HDL characteristics (related to size, particle distribution, and cholesterol and triglyceride content) are related to CAD risk while HDL cholesterol levels are not. (C) 2020 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- High-density lipoprotein
- HDL quality
- Coronary artery disease
- Mendelian randomization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Vilahur, Gemma
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- Marrugat, Jaume
- Fito, Montserrat
- Hernaez, Alvaro
- Elosua, Roberto
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