Brushite foams - the effect of Tween® 80 and Pluronic® F-127 on foam porosity and mechanical properties

• Resorbable calcium phosphate  based bone void  fillers  should work as  temporary  templates  for new bone formation. The incorporation of macropores with sizes of 100 -300 µm has been shown to  increase the resorption rate of the implant and speed up bone ingrowth. In this work, macroporous brushite cements were fabricated through foaming of the cement paste, utilizing two different synthetic surfactants,  Tween® 80 and Pluronic® F-127.  The macropores formed in the Pluronic  samples  were  both smaller and less  homogeneously  distributed  compared with  the pores formed in the Tween samples. The porosity and compressive strength were comparable to previously developed hydroxyapatite foams. The cement foam containing Tween, 0.5 M citric acid in the liquid, 1 mass% of disodium dihydrogen pyrophosphate mixed in the powder and a liquid to powder ratio  of 0.43  mL/g,  showed  the highest  porosity values  (76  %  total and  56  % macroporosity), while the compressive strength was higher than 1 MPa, i.e. the hardened cement could be handled without rupture of the foamed structure. The investigated brushite foams show potential for future clinical use, both as bone void fillers and as scaffolds for in vitro bone regeneration.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Materials (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Materialteknik -- Keramteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Materials Engineering -- Ceramics (hsv//eng)

Nyckelord

Brushite

foam

Tween® 80

Pluronic® F-127

porosity

strength

setting time

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