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  • Capodanno, DavideUniv Catania, Azienda Osped Univ Policlin Vittorio Emanuele, CAST PO G Rodolico, Div Cardiol, Catania, Italy (author)

Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-01-17
  • Springer Science and Business Media LLC,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-426079
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426079URI
  • https://doi.org/10.1038/s41569-019-0314-yDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Advances in antiplatelet therapies for patients with cardiovascular disease have improved patient outcomes over time, but the challenge of balancing the risks of ischaemia and bleeding remains substantial. Moreover, many patients with cardiovascular disease have a residual risk of ischaemic events despite receiving antiplatelet therapy. Therefore, novel strategies are needed to prevent clinical events through mechanisms beyond platelet inhibition and with an acceptable associated risk of bleeding. The advent of non-vitamin K antagonist oral anticoagulants, which attenuate fibrin formation by selective inhibition of factor Xa or thrombin, has renewed the interest in dual-pathway inhibition strategies that combine an antiplatelet agent with an anticoagulant drug. In this Review, we highlight the emerging pharmacological rationale and clinical development of dual-pathway inhibition strategies for the prevention of atherothrombotic events in patients with different manifestations of cardiovascular disease, such as coronary artery disease, cerebrovascular disease and peripheral artery disease. Many patients with cardiovascular disease have a residual risk of ischaemic events despite receiving antiplatelet therapy. In this Review, Angiolillo and colleagues discuss the pharmacological rationale and clinical development of dual-pathway inhibition strategies for the prevention of atherothrombotic events in patients with cardiovascular disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bhatt, Deepak L.Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA (author)
  • Eikelboom, John W.Hamilton Gen Hosp, Populat Hlth Res Inst, Hamilton, ON, Canada; McMaster Univ, Hamilton, ON, Canada (author)
  • Fox, Keith A. A.Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland (author)
  • Geisler, TobiasUniv Hosp Tubingen, Dept Cardiol & Angiol, Tubingen, Germany (author)
  • Gibson, C. MichaelHarvard Med Sch, Beth Israel Deaconess Med, Dept Med, Cardiovasc Div, Boston, MA 02115 USA (author)
  • Gonzalez-Juanatey, Jose RamonCIBERCV, IDIS, Univ Hosp, Cardiol Dept, Santiago De Compostela, Spain (author)
  • James, Stefan,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)stjam367 (author)
  • Lopes, Renato D.Duke Univ, Duke Clin Res Inst, Div Cardiol, Durham, NC USA (author)
  • Mehran, RoxanaIcahn Sch Med Mt Sinai, Cardiovasc Inst, New York, NY 10029 USA (author)
  • Montalescot, GillesSorbonne Univ, Pitie Salpetriere Hop, AP HP, ACTION Study Grp, Inst Cardiol, Paris, France (author)
  • Patel, ManeshDuke Univ, Duke Clin Res Inst, Div Cardiol, Durham, NC USA (author)
  • Steg, P. GabrielParis Univ, Hop Bichat, AP HP, FACT, INSERM, U1148, Paris, France (author)
  • Storey, Robert F.Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England (author)
  • Vranckx, PascalUniv Hasselt, Hartctr Hasselt, Dept Cardiol & Crit Care Med, Hasselt, Belgium; Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium (author)
  • Weitz, Jeffrey I.McMaster Univ, Dept Med, Hamilton, ON, Canada; McMaster Univ, Dept Biomed Sci, Hamilton, ON, Canada; Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada (author)
  • Welsh, RobertMazankowski Alberta Heart Inst, Cardiac Sci Dept, Edmonton, AB, Canada; Univ Alberta, Edmonton, AB, Canada (author)
  • Zeymer, UweKlinikum Ludwigshafen, Ludwigshafen, Germany; Inst Herzinfarktforsch, Ludwigshafen, Germany (author)
  • Angiolillo, Dominick J.Univ Florida, Coll Med, Div Cardiol, Jacksonville, FL USA (author)
  • Univ Catania, Azienda Osped Univ Policlin Vittorio Emanuele, CAST PO G Rodolico, Div Cardiol, Catania, ItalyHarvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA (creator_code:org_t)

Related titles

  • In:Nature Reviews Cardiology: Springer Science and Business Media LLC17:4, s. 242-2571759-50021759-5010

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