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Circadian variation...
Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging
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- Eckerbom, Per, 1974- (författare)
- Uppsala universitet,Radiologi
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- Hansell, Peter (författare)
- Uppsala universitet,Integrativ Fysiologi
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Cox, Eleanor (författare)
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Buchanan, Charlotte (författare)
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- Weis, Jan, 1956- (författare)
- Department of Medical Physics, Uppsala University Hospital
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- Palm, Fredrik, 1973- (författare)
- Uppsala universitet,Integrativ Fysiologi
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Francis, Susan (författare)
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- Liss, Per, 1960- (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- American Physiological Society, 2020
- 2020
- Engelska.
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Ingår i: American Journal of Physiology - Renal Physiology. - : American Physiological Society. - 1931-857X .- 1522-1466. ; 319:6, s. F966-F978
- Relaterad länk:
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https://nottingham-r...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Circadian regulation of kidney function is involved in maintaining whole body homeostasis, and dysfunctional circadian rhythm can potentially be involved in disease development. Magnetic resonance imaging (MRI) provides reliable and reproducible repetitive estimates of kidney function noninvasively without the risk of adverse events associated with contrast agents and ionizing radiation. The purpose of this study was to estimate circadian variations in kidney function in healthy human subjects with MRI and to relate the findings to urinary excretions of electrolytes and markers of kidney function. Phase-contrast imaging, arterial spin labeling, and blood oxygen level-dependent transverse relaxation rate (R2*) mapping were used to assess total renal blood flow and regional perfusion as well as intrarenal oxygenation in eight female and eight male healthy volunteers every fourth hour during a 24-h period. Parallel with MRI scans, standard urinary and plasma parameters were quantified. Significant circadian variations of total renal blood flow were found over 24 h, with increasing flow from noon to midnight and decreasing flow during the night. In contrast, no circadian variation in intrarenal oxygenation was detected. Urinary excretions of electrolytes, osmotically active particles, creatinine, and urea all displayed circadian variations, peaking during the afternoon and evening hours. In conclusion, total renal blood flow and kidney function, as estimated from excretion of electrolytes and waste products, display profound circadian variations, whereas intrarenal oxygenation displays significantly less circadian variation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- arterial spin labeling
- blood oxygen level dependent
- circadian variation
- healthy volunteers
- kidney function
- magnetic resonance imaging
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Eckerbom, Per, 1 ...
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Hansell, Peter
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Cox, Eleanor
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Buchanan, Charlo ...
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Weis, Jan, 1956-
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Palm, Fredrik, 1 ...
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visa fler...
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Francis, Susan
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Liss, Per, 1960-
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visa färre...
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Uppsala universitet