SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Brännstrom Johan)
 

Search: WFRF:(Brännstrom Johan) > Mapping endothelial...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Orsenigo, FabrizioFIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy. (author)

Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • eLife Sciences Publications, Ltd,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-426315
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426315URI
  • https://doi.org/10.7554/eLife.61413DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cerebral cavernous malformation (CCM) is a rare neurovascular disease that is characterized by enlarged and irregular blood vessels that often lead to cerebral hemorrhage. Loss-of-function mutations to any of three genes results in CCM lesion formation; namely, KRIT1, CCM2, and PDCD10 (CCM3). Here, we report for the first time in-depth single-cell RNA sequencing, combined with spatial transcriptomics and immunohistochemistry, to comprehensively characterize subclasses of brain endothelial cells (ECs) under both normal conditions and after deletion of Pdcd10 (Ccm3) in a mouse model of CCM. Integrated single-cell analysis identifies arterial ECs as refractory to CCM transformation. Conversely, a subset of angiogenic venous capillary ECs and respective resident endothelial progenitors appear to be at the origin of CCM lesions. These data are relevant for the understanding of the plasticity of the brain vascular system and provide novel insights into the molecular basis of CCM disease at the single cell level.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Conze, Lei LiuUppsala universitet,Vaskulärbiologi(Swepub:uu)leliu102 (author)
  • Jauhiainen, SuviUppsala universitet,Vaskulärbiologi(Swepub:uu)suvja782 (author)
  • Corada, MonicaFIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy. (author)
  • Lazzaroni, FrancescaFIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy. (author)
  • Malinverno, MatteoFIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy. (author)
  • Sundell, VeronicaUppsala universitet,Institutionen för immunologi, genetik och patologi (author)
  • Cunha, Sara IsabelUppsala universitet,Institutionen för immunologi, genetik och patologi (author)
  • Brännstrom, JohanUppsala universitet,Institutionen för immunologi, genetik och patologi (author)
  • Globisch, Maria A.Uppsala universitet,Vaskulärbiologi(Swepub:uu)margl506 (author)
  • Maderna, ClaudioFIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy. (author)
  • Lampugnani, Maria GraziaFIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy.;Mario Negri Inst Pharmacol Res, Milan, Italy. (author)
  • Magnusson, PeetraUppsala universitet,Vaskulärbiologi(Swepub:uu)petrmagn (author)
  • Dejana, ElisabettaUppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy.(Swepub:uu)elide443 (author)
  • FIRC Inst Mol Oncol Fdn IFOM, Vasc Biol Unit, Milan, Italy.Vaskulärbiologi (creator_code:org_t)

Related titles

  • In:eLIFE: eLife Sciences Publications, Ltd92050-084X

Internet link

Find in a library

  • eLIFE (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view