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  • Genereux, Diane P.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA. (author)

A comparative genomics multitool for scientific discovery and conservation

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-11-11
  • NATURE RESEARCH,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-426812
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426812URI
  • https://doi.org/10.1038/s41586-020-2876-6DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145123578URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Group Authors: Zoonomia Consortium
  • A whole-genome alignment of 240 phylogenetically diverse species of eutherian mammal-including 131 previously uncharacterized species-from the Zoonomia Project provides data that support biological discovery, medical research and conservation. The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Serres, AitorPRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain. (author)
  • Armstrong, JoelUniv Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA. (author)
  • Johnson, JeremyKarolinska Institutet (author)
  • Marinescu, VoichitaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)voima415 (author)
  • Murén, EvaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)evmur020 (author)
  • Juan, DavidPRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain. (author)
  • Bejerano, GillStanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA.;Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA.;Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA.;Stanford Univ, Dept Pediat, Stanford, CA 94305 USA. (author)
  • Casewell, Nicholas R.Univ Liverpool Liverpool Sch Trop Med, Ctr Snakebite Res & Intervent, Liverpool, Merseyside, England. (author)
  • Chemnick, Leona G.Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA. (author)
  • Damas, JoanaUniv Calif Davis, UC Davis Genome Ctr, Davis, CA 95616 USA. (author)
  • Di Palma, FedericaUniv East Anglia, Dept Biol Sci, Norwich, Norfolk, England.;Earlham Inst, Norwich, Norfolk, England. (author)
  • Diekhans, MarkUniv Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA. (author)
  • Fiddes, Ian T.Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA. (author)
  • Garber, ManuelUniv Massachusetts, Sch Med, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA. (author)
  • Gladyshev, Vadim N.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA. (author)
  • Goodman, LindaBroad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA.;Fauna Bio Inc, Emeryville, CA USA. (author)
  • Haerty, WilfriedEarlham Inst, Norwich, Norfolk, England. (author)
  • Houck, Marlys L.Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA. (author)
  • Hubley, RobertInst Syst Biol, Seattle, WA USA. (author)
  • Kivioja, TeemuUniv Cambridge, Dept Biochem, Cambridge, England.;Univ Helsinki, Appl Tumor Genom Res Program, Helsinki, Finland. (author)
  • Koepfli, Klaus-PeterSmithsonian Mason Sch Conservat, Front Royal, VA USA. (author)
  • Kuderna, Lukas F. K.PRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain. (author)
  • Lander, Eric S.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;MIT, Dept Biol, Cambridge, MA USA.;Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA. (author)
  • Meadows, JenniferUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)jenme818 (author)
  • Murphy, William J.Texas A&M Univ, Vet Integrat Biosci, College Stn, TX USA. (author)
  • Nash, WillEarlham Inst, Norwich, Norfolk, England. (author)
  • Noh, Hyun JiBroad Inst MIT & Harvard, Cambridge, MA 02142 USA. (author)
  • Nweeia, MartinSmithsonian Inst, Marine Mammal Program, Washington, DC 20560 USA.;Harvard Sch Dent Med, Restorat Dent & Biomat Sci, Boston, MA USA.;Case Western Reserve Univ, Sch Dent Med, Cleveland, OH 44106 USA. (author)
  • Pfenning, Andreas R.Carnegie Mellon Univ, Sch Comp Sci, Dept Computat Biol, Pittsburgh, PA 15213 USA. (author)
  • Pollard, Katherine S.Chan Zuckerberg Biohub, San Francisco, CA USA.;Gladstone Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, Inst Computat Hlth Sci, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA. (author)
  • Ray, David A.Texas Tech Univ, Dept Sci Biol, Lubbock, TX 79409 USA. (author)
  • Shapiro, BethUniv Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA.;Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA. (author)
  • Smit, Arian F. A.Inst Syst Biol, Seattle, WA USA. (author)
  • Springer, Mark S.Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 92521 USA. (author)
  • Steiner, Cynthia C.Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA. (author)
  • Swofford, RossBroad Inst MIT & Harvard, Cambridge, MA 02142 USA. (author)
  • Taipale, JussiUniv Cambridge, Dept Biochem, Cambridge, England.;Univ Helsinki, Appl Tumor Genom Res Program, Helsinki, Finland.;Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden. (author)
  • Teeling, Emma C.Univ Coll Dublin, Sch Biol & Environm Sci, Dublin, Ireland. (author)
  • Turner-Maier, JasonBroad Inst MIT & Harvard, Cambridge, MA 02142 USA. (author)
  • Alfoldi, JessicaBroad Inst MIT & Harvard, Cambridge, MA 02142 USA. (author)
  • Birren, BruceBroad Inst MIT & Harvard, Cambridge, MA 02142 USA. (author)
  • Ryder, Oliver A.Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA.;Univ Calif San Diego, Div Biol, Dept Evolut Behav & Ecol, San Diego, CA 92103 USA. (author)
  • Lewin, Harris A.Univ Calif Davis, UC Davis Genome Ctr, Davis, CA 95616 USA.;Univ Calif Davis, Dept Evolut & Ecol, Davis, CA 95616 USA. (author)
  • Paten, BenedictUniv Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA. (author)
  • Marques-Bonet, TomasPRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain.;Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain.;Univ Autonoma Barcelona, Inst Catala Paleontol Miquel Crusafont, Barcelona, Spain.;Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain. (author)
  • Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA(Swepub:uu)kerli865 (author)
  • Karlsson, Elinor K.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Univ Massachusetts, Sch Med, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.;Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA. (author)
  • Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.PRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain. (creator_code:org_t)

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  • In:Nature: NATURE RESEARCH587:7833, s. 240-2450028-08361476-4687

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