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Comparison of outco...
Comparison of outcomes of HCT in blast phase of BCR-ABL1- MPN with de novo AML and with AML following MDS
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- Gupta, Vikas (författare)
- Princess Margaret Canc Ctr, 700 Univ Ave,6-326, Toronto, ON M5G 1Z5, Canada.
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- Kim, Soyoung (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA.
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- Hu, Zhen-Huan (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.
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- Liu, Ying (författare)
- Columbia Univ, Dept Psychiat, Mental Hlth Data Sci, Irving Med Ctr, New York, NY USA.
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- Aljurf, Mahmoud (författare)
- King Faisal Specialist Hosp Ctr & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia.
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- Bacher, Ulrike (författare)
- Univ Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland.
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- Beitinjaneh, Amer (författare)
- Univ Miami, Div Transplantat & Cellular Therapy, Miami, FL USA.
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- Cahn, Jean-Yves (författare)
- Ctr Hosp Univ CHU Grenoble Alpes, Dept Hematol, Grenoble, France.
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- Cerny, Jan (författare)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
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- Copelan, Edward (författare)
- Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA.
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- Gadalla, Shahinaz M. (författare)
- NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, NIH, Rockville, MD USA.
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- Gale, Robert Peter (författare)
- Imperial Coll London, Haematol Res Ctr, Dept Immunol & Inflammat, London, England.
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- Ganguly, Siddhartha (författare)
- Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.
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- George, Biju (författare)
- Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
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- Gerds, Aaron T. (författare)
- Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA.
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- Gergis, Usama (författare)
- Thomas Jefferson Univ, Div Hematol Malignancies, Dept Med Oncol, Philadelphia, PA 19107 USA.
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- Hamilton, Betty K. (författare)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- Hashmi, Shahrukh (författare)
- Mayo Clin, Dept Internal Med, Rochester, MN USA.;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia.
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- Hildebrandt, Gerhard C. (författare)
- Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
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- Kamble, Rammurti T. (författare)
- Baylor Univ, Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX USA.
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- Kindwall-Keller, Tamila (författare)
- Univ Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA.
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- Lazarus, Hillard M. (författare)
- Case Western Reserve Univ, Cleveland Med Ctr, Univ Hosp, Cleveland, OH 44106 USA.
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- Liesveld, Jane L. (författare)
- Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.
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- Litzow, Mark (författare)
- Mayo Clin Rochester, Div Hematol & Transplant Ctr, Rochester, MN USA.
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- Maziarz, Richard T. (författare)
- Oregon Hlth & Sci Univ, Knight Canc Inst, Adult Blood & Marrow Stem Cell Transplant Program, Portland, OR 97201 USA.
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- Nishihori, Taiga (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
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- Olsson, Richard (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
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- Rizzieri, David (författare)
- Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.
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- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Seo, Sachiko (författare)
- Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.
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- Solh, Melhem (författare)
- Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.
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- Szer, Jeff (författare)
- Royal Melbourne Hosp, Clin Haematol, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia.
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- Verdonck, Leo F. (författare)
- Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.
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- Wirk, Baldeep (författare)
- Penn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA.
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- Woolfrey, Ann (författare)
- Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
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- Yared, Jean A. (författare)
- Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.
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- Alyea, Edwin P. (författare)
- Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.
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- Popat, Uday R. (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA.
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- Sobecks, Ronald M. (författare)
- Cleveland Clin, Hematol & Med Oncol, Cleveland, OH 44106 USA.
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- Scott, Bart L. (författare)
- Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
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- Nakamura, Ryotaro (författare)
- City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.
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- Saber, Wael (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.
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Princess Margaret Canc Ctr, 700 Univ Ave,6-326, Toronto, ON M5G 1Z5, Canada Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA. (creator_code:org_t)
- 2020-10-02
- 2020
- Engelska.
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 4:19, s. 4748-4757
- Relaterad länk:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Comparative outcomes of allogeneic hematopoietic cell transplantation (HCT) for BCR-ABL12 myeloproliferative neoplasms (MPNs) in blast phase (MPN-BP) vs de novo acute myeloid leukemia (AML), and AML with prior myelodysplastic syndromes (MDSs; post-MDS AML), are unknown. Using the Center for International Blood and Marrow Transplant Research (CIBMTR) database, we compared HCT outcomes in 177 MPN-BP patients with 4749 patients with de novo AML, and 1104 patients with post-MDS AML, using multivariate regression analysis in 2 separate comparisons. In a multivariate Cox model, no difference in overall survival (OS) or relapse was observed in patients with MPN-BP vs de novo AML with active leukemia at HCT. Patients with MPN-BP in remission had inferior OS in comparison with de novo AML in remission (hazard ratio [HR], 1.40 [95% confidence interval [ CI], 1.12-1.76]) due to higher relapse rate (HR, 2.18 [95% CI, 1.69-2.80]). MPN-BP patients had inferior OS (HR, 1.19 [95% CI, 1.00-1.43]) and increased relapse (HR, 1.60 [95% CI, 1.31-1.96]) compared with post-MDS AML. Poor-risk cytogenetics were associated with increased relapse in both comparisons. Peripheral blood grafts were associated with decreased relapse in MPN-BP and post-MDS AML (HR, 0.70 [95% CI, 0.57-0.86]). Nonrelapse mortality (NRM) was similar between MPN-BP vs de novo AML, and MPN-BP vs post-MDS AML. Total-body irradiation-based myeloablative conditioning was associated with higher NRM in both comparisons. Survival of MPN-BP after HCT is inferior to de novo AML in remission and post-MDS AML due to increased relapse. Relapse-prevention strategies are required to optimize HCT outcomes in MPN-BP.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Gupta, Vikas
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Kim, Soyoung
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Hu, Zhen-Huan
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Liu, Ying
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Aljurf, Mahmoud
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Bacher, Ulrike
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Beitinjaneh, Ame ...
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Cahn, Jean-Yves
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Cerny, Jan
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Copelan, Edward
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Gadalla, Shahina ...
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Gale, Robert Pet ...
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Ganguly, Siddhar ...
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George, Biju
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Gerds, Aaron T.
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Gergis, Usama
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Hamilton, Betty ...
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Hashmi, Shahrukh
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Hildebrandt, Ger ...
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Kamble, Rammurti ...
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Kindwall-Keller, ...
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Lazarus, Hillard ...
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Liesveld, Jane L ...
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Litzow, Mark
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Maziarz, Richard ...
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Nishihori, Taiga
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Olsson, Richard
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Rizzieri, David
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Savani, Bipin N.
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Seo, Sachiko
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Solh, Melhem
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Szer, Jeff
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Verdonck, Leo F.
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Wirk, Baldeep
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Woolfrey, Ann
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Yared, Jean A.
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Alyea, Edwin P.
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Popat, Uday R.
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Sobecks, Ronald ...
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Scott, Bart L.
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Nakamura, Ryotar ...
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Saber, Wael
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