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  • Bomholt, TobiasDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (author)

The Use of HbA1c, Glycated Albumin and Continuous Glucose Monitoring to Assess Glucose Control in the Chronic Kidney Disease Population Including Dialysis.

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-12-02
  • S. Karger AG,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-427096
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427096URI
  • https://doi.org/10.1159/000511614DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Glycated haemoglobin A1c (HbA1c) has limitations as a glycemic marker for patients with diabetes and CKD and for those receiving dialysis. Glycated albumin is an alternative glycemic marker, and some studies have found that glycated albumin more accurately reflects glycemic control than HbA1c in these groups. However, several factors are known to influence the value of glycated albumin including proteinuria. Continuous glucose monitoring (CGM) is another alternative to HbA1c. CGM allows one to assess mean glucose, glucose variability, and the time spent in hypo-, normo-, and hyperglycemia. Currently, several different CGM models are approved for use in patients receiving dialysis; CKD (not on dialysis) is not a contraindication in any of these models. Some devices are for blind recording, while others provide real-time data to patients. Small studies suggest that CGM could improve glycemic control in hemodialysis patients, but this has not been studied for individual CKD stages.SUMMARY: Glycated albumin and CGM avoid the pitfalls of HbA1c in CKD and dialysis populations. However, the value of glycated albumin may be affected by several factors. CGM provides a precise estimation of the mean glucose. Here, we discuss the strengths and limitations for using HbA1c, glycated albumin, or CGM in CKD and dialysis population. Key Messages: Glycated albumin is an alternative glycemic marker but is affected by proteinuria. CGM provides a precise estimation of mean glucose and glucose variability. It remains unclear if CGM improves glycemic control in the CKD and dialysis populations.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Adrian, ThereseDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (author)
  • Nørgaard, KirstenSteno Diabetes Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. (author)
  • Ranjan, Ajenthen GSteno Diabetes Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. (author)
  • Almdal, ThomasDepartment of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. (author)
  • Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (author)
  • Vadstrup, MetteDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (author)
  • Rix, MarianneDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (author)
  • Feldt-Rasmussen, BoDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (author)
  • Hornum, MadsDepartment of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (author)
  • Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Steno Diabetes Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. (creator_code:org_t)

Related titles

  • In:Nephron. Clinical practice: S. Karger AG145:1, s. 14-191660-81512235-3186

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