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- Berntson, Lillemor,1957-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa (author)
A Pilot Study Investigating Faecal Microbiota After Two Dietary Interventions in Children with Juvenile Idiopathic Arthritis
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-06-07
- Springer Science and Business Media LLC,2022
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-427154
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427154URI
- https://doi.org/10.1007/s00284-022-02899-1DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:149769602URI
- https://res.slu.se/id/publ/117552URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- There is evidence for an impact of the gut microbiota on the immune system, which has consequences for inflammatory diseases. Exclusive enteral nutrition (EEN) and the specific carbohydrate diet (SCD) have been demonstrated as effective anti-inflammatory treatments for children with Crohn’s disease. We have previously shown an anti-inflammatory effect from these nutritional treatments in children with juvenile idiopathic arthritis (JIA). The aim of this study was to investigate if improved clinical symptoms after EEN or SCD treatment in children with JIA could be linked to changes in faecal microbiota. We included sixteen patients with JIA (age 7–17 years), six for treatment with EEN and ten with SCD. EEN was given for 3–5 weeks and SCD for 4–5 weeks, with clinical and laboratory status assessed before and after treatment. Faecal samples were analysed for microbiota diversity and composition using 16S rRNA gene sequencing. Analyses of the faecal microbiota showed an effect on the overall composition with both interventions; the most striking result was a decreased relative abundance of the genus Faecalibacterium from EEN and of Bifidobacterium from SCD. The α-diversity decreased significantly from SCD (P = 0.04), but not from EEN (P = 0.22). Despite the study cohorts being small, both EEN and SCD were shown to impact the faecal microbiota. Future larger studies with a focus on metagenomics or metabolomics could possibly reveal a link and clarify the clinical effects of those nutritional regimens.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Öman, Anders,1975-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa(Swepub:uu)andom429 (author)
- Engstrand, Lars (author)
- Dicksved, JohanSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens utfodring och vård (HUV),Department of Animal Nutrition and Management(Swepub:slu)47518 (author)
- Uppsala universitetPediatrisk inflammations- och metabolismforskning samt barnhälsa (creator_code:org_t)
- Sveriges lantbruksuniversitet
Related titles
- In:Current Microbiology: Springer Science and Business Media LLC79:70343-86511432-0991
Internet link
- https://doi.org/10.1007/s00284-022-02899-1Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1506535/FULLTEXT01.pdffulltext:print
- https://pub.epsilon.slu.se/id/eprint/28414/contentsFULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427154
- https://doi.org/10.1007/s00284-022-02899-1
- http://kipublications.ki.se/Default.aspx?queryparsed=id:149769602
- https://res.slu.se/id/publ/117552
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