Combined associations of a polygenic risk score and classical risk factors with breast cancer risk

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Kapoor, Pooja Middha (author)

Combined associations of a polygenic risk score and classical risk factors with breast cancer risk

Article/chapterEnglish2021

Publisher, publication year, extent ...

2020-05-02
Oxford University Press (OUP),2021
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-427567
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427567URI
https://doi.org/10.1093/jnci/djaa056DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:146374388URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
Breast cancer
Epidemiology
Gene-environment interactions
Genetic susceptibility
Polygenic risk score
Risk factors
Risk prediction

Added entries (persons, corporate bodies, meetings, titles ...)

Mavaddat, Nasim (author)
Choudhury, Parichoy Pal (author)
Wilcox, Amber N. (author)
Lindström, Sara (author)
Behrens, Sabine (author)
Michailidou, Kyriaki (author)
Dennis, Joe (author)
Bolla, Manjeet K. (author)
Wang, Qin (author)
Jung, Audrey (author)
Abu-Ful, Zomoroda (author)
Ahearn, Thomas (author)
Andrulis, Irene L. (author)
Anton-Culver, Hoda (author)
Arndt, Volker (author)
Aronson, Kristan J. (author)
Auer, Paul L. (author)
Beane Freeman, Laura E. (author)
Becher, Heiko (author)
Beckmann, Matthias W. (author)
Beeghly-Fadiel, Alicia (author)
Benitez, Javier (author)
Bernstein, Leslie (author)
Bojesen, Stig E. (author)
Brauch, Hiltrud (author)
Brenner, Hermann (author)
Brüning, Thomas (author)
Cai, Qiuyin (author)
Campa, Daniele (author)
Canzian, Federico (author)
Carracedo, Angel (author)
Carter, Brian D. (author)
Castelao, Jose E. (author)
Chanock, Stephen J. (author)
Chatterjee, Nilanjan (author)
Chenevix-Trench, Georgia (author)
Clarke, Christine L. (author)
Couch, Fergus J. (author)
Cox, Angela (author)
Cross, Simon S. (author)
Czene, KamilaKarolinska Institutet (author)
Dai, James Y. (author)
Earp, H. Shelton (author)
Ekici, Arif B. (author)
Eliassen, A. Heather (author)
Eriksson, MikaelKarolinska Institutet (author)
Evans, D. Gareth (author)
Fasching, Peter A. (author)
Figueroa, Jonine (author)
Fritschi, Lin (author)
Gabrielson, MarikeKarolinska Institutet (author)
Gago-Dominguez, Manuela (author)
Gao, Chi (author)
Gapstur, Susan M. (author)
Gaudet, Mia M. (author)
Giles, Graham G. (author)
González-Neira, Anna (author)
Guénel, Pascal (author)
Haeberle, Lothar (author)
Haiman, Christopher A. (author)
Håkansson, NiclasKarolinska Institutet (author)
Hall, PerKarolinska Institutet (author)
Hamann, Ute (author)
Hatse, Sigrid (author)
Heyworth, Jane (author)
Holleczek, Bernd (author)
Hoover, Robert N. (author)
Hopper, John L. (author)
Howell, Anthony (author)
Hunter, David J. (author)
John, Esther M. (author)
Jones, Michael E. (author)
Kaaks, Rudolf (author)
Keeman, Renske (author)
Kitahara, Cari M. (author)
Ko, Yon-Dschun (author)
Koutros, Stella (author)
Kurian, Allison W.Karolinska Institutet (author)
Lambrechts, Diether (author)
Le Marchand, Loic (author)
Lee, Eunjung (author)
Lejbkowicz, Flavio (author)
Linet, Martha (author)
Lissowska, Jolanta (author)
Llaneza, Ana (author)
MacInnis, Robert J. (author)
Martinez, Maria Elena (author)
Maurer, Tabea (author)
McLean, Catriona (author)
Neuhausen, Susan L. (author)
Newman, William G. (author)
Norman, Aaron (author)
O'Brien, Katie M. (author)
Olshan, Andrew F. (author)
Olson, Janet E. (author)
Olsson, Håkan (author)
Orr, Nick (author)
Perou, Charles M. (author)
Pita, Guillermo (author)
Polley, Eric C. (author)
Prentice, Ross L. (author)
Rennert, Gad (author)
Rennert, Hedy S. (author)
Ruddy, Kathryn J. (author)
Sandler, Dale P. (author)
Saunders, Christobel (author)
Schoemaker, Minouk J. (author)
Schöttker, Ben (author)
Schumacher, Fredrick (author)
Scott, Christopher (author)
Scott, Rodney J. (author)
Shu, Xiao-Ou (author)
Smeets, Ann (author)
Southey, Melissa C. (author)
Spinelli, John J. (author)
Stone, Jennifer (author)
Swerdlow, Anthony J. (author)
Tamimi, Rulla M. (author)
Taylor, Jack A. (author)
Troester, Melissa A. (author)
Vachon, Celine M. (author)
van Veen, Elke M. (author)
Wang, Xiaoliang (author)
Weinberg, Clarice R. (author)
Weltens, Caroline (author)
Willett, Walter (author)
Winham, Stacey J. (author)
Wolk, AlicjaUppsala universitet,Medicinsk epidemiologi,Karolinska institutet(Swepub:uu)alwol516 (author)
Yang, Xiaohong R. (author)
Zheng, Wei (author)
Ziogas, Argyrios (author)
Dunning, Alison M. (author)
Pharoah, Paul D. P. (author)
Schmidt, Marjanka K. (author)
Kraft, Peter (author)
Easton, Douglas F. (author)
Milne, Roger L. (author)
García-Closas, Montserrat (author)
Chang-Claude, Jenny (author)
Karolinska InstitutetMedicinsk epidemiologi (creator_code:org_t)

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In:Journal of the National Cancer Institute: Oxford University Press (OUP)113:3, s. 329-3370027-88741460-2105

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By the author/editor: Kapoor, Pooja Mi ...; Mavaddat, Nasim; Choudhury, Paric ...; Wilcox, Amber N.; Lindström, Sara; Behrens, Sabine; show more...; Michailidou, Kyr ...; Dennis, Joe; Bolla, Manjeet K ...; Wang, Qin; Jung, Audrey; Abu-Ful, Zomorod ...; Ahearn, Thomas; Andrulis, Irene ...; Anton-Culver, Ho ...; Arndt, Volker; Aronson, Kristan ...; Auer, Paul L.; Beane Freeman, L ...; Becher, Heiko; Beckmann, Matthi ...; Beeghly-Fadiel, ...; Benitez, Javier; Bernstein, Lesli ...; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Brüning, Thomas; Cai, Qiuyin; Campa, Daniele; Canzian, Federic ...; Carracedo, Angel; Carter, Brian D.; Castelao, Jose E ...; Chanock, Stephen ...; Chatterjee, Nila ...; Chenevix-Trench, ...; Clarke, Christin ...; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Dai, James Y.; Earp, H. Shelton; Ekici, Arif B.; Eliassen, A. Hea ...; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter ...; Figueroa, Jonine; Fritschi, Lin; Gabrielson, Mari ...; Gago-Dominguez, ...; Gao, Chi; Gapstur, Susan M ...; Gaudet, Mia M.; Giles, Graham G.; González-Neira, ...; Guénel, Pascal; Haeberle, Lothar; Haiman, Christop ...; Håkansson, Nicla ...; Hall, Per; Hamann, Ute; Hatse, Sigrid; Heyworth, Jane; Holleczek, Bernd; Hoover, Robert N ...; Hopper, John L.; Howell, Anthony; Hunter, David J.; John, Esther M.; Jones, Michael E ...; Kaaks, Rudolf; Keeman, Renske; Kitahara, Cari M ...; Ko, Yon-Dschun; Koutros, Stella; Kurian, Allison ...; Lambrechts, Diet ...; Le Marchand, Loi ...; Lee, Eunjung; Lejbkowicz, Flav ...; Linet, Martha; Lissowska, Jolan ...; Llaneza, Ana; MacInnis, Robert ...; Martinez, Maria ...; Maurer, Tabea; McLean, Catriona; Neuhausen, Susan ...; Newman, William ...; Norman, Aaron; O'Brien, Katie M ...; Olshan, Andrew F ...; Olson, Janet E.; Olsson, Håkan; Orr, Nick; Perou, Charles M ...; Pita, Guillermo; Polley, Eric C.; Prentice, Ross L ...; Rennert, Gad; Rennert, Hedy S.; Ruddy, Kathryn J ...; Sandler, Dale P.; Saunders, Christ ...; Schoemaker, Mino ...; Schöttker, Ben; Schumacher, Fred ...; Scott, Christoph ...; Scott, Rodney J.; Shu, Xiao-Ou; Smeets, Ann; Southey, Melissa ...; Spinelli, John J ...; Stone, Jennifer; Swerdlow, Anthon ...; Tamimi, Rulla M.; Taylor, Jack A.; Troester, Meliss ...; Vachon, Celine M ...; van Veen, Elke M ...; Wang, Xiaoliang; Weinberg, Claric ...; Weltens, Carolin ...; Willett, Walter; Winham, Stacey J ...; Wolk, Alicja; Yang, Xiaohong R ...; Zheng, Wei; Ziogas, Argyrios; Dunning, Alison ...; Pharoah, Paul D. ...; Schmidt, Marjank ...; Kraft, Peter; Easton, Douglas ...; Milne, Roger L.; García-Closas, M ...; Chang-Claude, Je ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Journal of the N ...

By the university: Uppsala University; Karolinska Institutet

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