Personality Factors' Impact on the Structural Integrity of Mentalizing Network in Old Age: A Combined PET-MRI Study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: (WFRF:(Giannakopoulos Panteleimon)) > Personality Factors...

Details
MARC

Giannakopoulos, PanteleimonUniv Geneva, Dept Psychiat, Geneva, Switzerland; Geneva Univ Hosp, Med Direct, Geneva, Switzerland (author)

Personality Factors' Impact on the Structural Integrity of Mentalizing Network in Old Age : A Combined PET-MRI Study

Article/chapterEnglish2020

Publisher, publication year, extent ...

2020-11-17
Frontiers Media SA,2020
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-428990
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428990URI
https://doi.org/10.3389/fpsyt.2020.552037DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The mentalizing network (MN) treats social interactions based on our understanding of other people's intentions and includes the medial prefrontal cortex (mPFC), temporoparietal junction (TPJ), posterior cingulate cortex (PCC), precuneus (PC), and amygdala. Not all elders are equally affected by the aging-related decrease of mentalizing abilities. Personality has recently emerged as a strong determinant of functional connectivity in MN areas. However, its impact on volumetric changes across the MN in brain aging is still unknown. To address this issue, we explored the determinants of volume decrease in MN components including amyloid burden, personality, and APOE genotyping in a previously established cohort of 130 healthy elders with a mean follow-up of 54 months. Personality was assessed with the Neuroticism Extraversion Openness Personality Inventory-Revised. Regression models corrected for multiple comparisons were used to identify predictors of volume loss including time, age, sex, personality, amyloid load, presence of APOE epsilon 4 allele, and cognitive evolution. In cases with higher Agreeableness scores, there were lower volume losses in PCC, PC, and amygdala bilaterally. This was also the case for the right mPFC in elders displaying lower Agreeableness and Conscientiousness. In multiple regression models, the effect of Agreeableness was still observed in left PC and right amygdala and that of Conscientiousness was still observed in right mPFC volume loss (26.3% of variability, significant age and sex). Several Agreeableness (Modesty) and Conscientiousness (order, dutifulness, achievement striving, and self-discipline) facets were positively related to increased volume loss in cortical components of the MN. In conclusion, these data challenge the beneficial role of higher levels of Agreeableness and Conscientiousness in old age, showing that they are associated with an increased rate of volume loss within the MN.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
amyloid load
cohort studies
mentalizing
personality
structural MRI

Added entries (persons, corporate bodies, meetings, titles ...)

Rodriguez, CristelleUniv Geneva, Dept Psychiat, Geneva, Switzerland; Geneva Univ Hosp, Med Direct, Geneva, Switzerland (author)
Montandon, Marie-LouiseUniv Geneva, Dept Psychiat, Geneva, Switzerland; Geneva Univ Hosp, Med Direct, Geneva, Switzerland; Geneva Univ Hosp, Dept Readaptat & Geriatr, Geneva, Switzerland; Univ Geneva, Geneva, Switzerland (author)
Garibotto, ValentinaGeneva Univ Hosp, Div Nucl Med & Mol Imaging, Diagnost Dept, Geneva, Switzerland; Univ Geneva, Fac Med, Geneva, Switzerland (author)
Haller, SvenUppsala universitet,Radiologi,Univ Geneva, Fac Med, Geneva, Switzerland; CIRD Ctr Rive Droite, Geneva, Switzerland(Swepub:uu)sveha228 (author)
Herrmann, Francois R.Geneva Univ Hosp, Dept Readaptat & Geriatr, Geneva, Switzerland; Univ Geneva, Geneva, Switzerland (author)
Univ Geneva, Dept Psychiat, Geneva, Switzerland; Geneva Univ Hosp, Med Direct, Geneva, SwitzerlandUniv Geneva, Dept Psychiat, Geneva, Switzerland; Geneva Univ Hosp, Med Direct, Geneva, Switzerland; Geneva Univ Hosp, Dept Readaptat & Geriatr, Geneva, Switzerland; Univ Geneva, Geneva, Switzerland (creator_code:org_t)

Related titles

In:Frontiers in Psychiatry: Frontiers Media SA111664-0640

Internet link

Find in a library

Frontiers in Psychiatry (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Giannakopoulos, ...; Rodriguez, Crist ...; Montandon, Marie ...; Garibotto, Valen ...; Haller, Sven; Herrmann, Franco ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Geriatrics

Articles in the publication: Frontiers in Psy ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se