Genetic variance and plasma concentration of CD93 is associated with cardiovascular mortality: Results from a 6.7-year follow-up of a healthy community-living elderly population

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Alehagen, Urban,1951-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten (författare)

Genetic variance and plasma concentration of CD93 is associated with cardiovascular mortality : Results from a 6.7-year follow-up of a healthy community-living elderly population

Artikel/kapitelEngelska2020

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2020-10-01
Spandidos Publications,2020
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-428995
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428995URI
https://doi.org/10.3892/mmr.2020.11555DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-172100URI

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Språk:engelska
Sammanfattning på:engelska

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Funding Agencies|County Council of Ostergotland, University of Linkoping, Linkoping, Sweden; Swedish Heart and Lung FoundationSwedish Heart-Lung Foundation
Inflammation is one of the fundamental processes in numerous diseases. Cluster of differentiation (CD) 93, a glycoprotein, has been reported to be associated with a number of these diseases. There are reports indicating that a high plasma level of CD93 is associated with adverse events in ischaemic heart disease. Additionally, there are reports indicating different cardiovascular risks between different single nucleotide polymorphisms (SNPs) of CD93. Therefore, the present study aimed to determine whether the plasma concentration of CD93 and polymorphism of rs2749812 in CD93 were associated with clinical conditions and mortality in an elderly population. In 470 healthy elderly community-living individuals a novel clinical examination involving echocardiography and blood sampling was performed. The population was followed for 6.7 years. Plasma levels of CD93 and SNP analyses of rs2749812 of CD93 using PCR methodology were used. During the follow-up period, 106 (22.6%) all-cause and 61 (13.0%) cardiovascular deaths were registered. Those with the highest plasma concentration had markedly higher all-cause mortality. Evaluating the A/A, A/G and G/G genotypes, the G/G group exhibited significantly higher cardiovascular mortality (P=0.026), and an almost two-fold increased risk in a multivariate Cox regression model compared with the A/G genotype. Evaluation of subgroups with respect to sex, diabetes and hypertension revealed markedly increased cardiovascular risk in the G/G genotype in all subgroups. All results persisted in the multiple models used. In the present study, the glycoprotein CD93 was demonstrated to have prognostic cardiovascular information, with increased risk for those with a high plasma concentration. Furthermore, the G/G genotype of rs2749812 of CD93 has a significantly higher cardiovascular risk, as demonstrated here, and could therefore be regarded as a possible cardiovascular risk biomarker that might in the future be used to offer optimised cardiovascular patient handling. However, this was a small study, and more research is required.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
CD93
genotypes
elderly
mortality

Biuppslag (personer, institutioner, konferenser, titlar ...)

Shamoun, LevarUppsala universitet,Institutionen för medicinsk cellbiologi,Jönköping Cty, Div Med Diagnost, Dept Lab Med, SE-55305 Jönköping, Sweden,Jonkoping Cty, Sweden; Uppsala Univ, Sweden(Swepub:uu)levsh176 (författare)
Wågsäter, Dick,ProfessorUppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala Univ, Sweden(Swepub:uu)dicwa895 (författare)
Linköpings universitetAvdelningen för diagnostik och specialistmedicin (creator_code:org_t)

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Ingår i:Molecular Medicine Reports: Spandidos Publications22:6, s. 4629-46361791-29971791-3004

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Av författaren/redakt...: Alehagen, Urban, ...; Shamoun, Levar; Wågsäter, Dick, ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

Artiklar i publikationen: Molecular Medici ...

Av lärosätet: Uppsala universitet; Linköpings universitet

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