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  • Remes, Tiina MariaOulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland (författare)

Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-02-07
  • Oxford University Press (OUP),2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-428999
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428999URI
  • https://doi.org/10.1093/nop/npaa002DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundCranial radiotherapy may damage the cerebral vasculature. The aim of this study was to understand the prevalence and risk factors of cerebrovascular disease (CVD) and white matter hyperintensities (WMHs) in childhood brain tumors (CBT) survivors treated with radiotherapy.MethodsSeventy CBT survivors who received radiotherapy were enrolled in a cross-sectional study at a median 20 years after radiotherapy cessation. The prevalence of and risk factors for CVD were investigated using MRI, MRA, and laboratory testing. Tumors, their treatment, and stroke-related data were retrieved from patients’ files.ResultsForty-four individuals (63%) had CVD at a median age of 27 years (range, 16-43 years). The prevalence rates at 20 years for CVD, small-vessel disease, and large-vessel disease were 52%, 38%, and 16%, respectively. Ischemic infarcts were diagnosed in 6 survivors, and cerebral hemorrhage in 2. Lacunar infarcts were present in 7, periventricular or deep WMHs in 34 (49%), and mineralizing microangiopathy in 21 (30%) survivors. Multiple pathologies were detected in 44% of the participants, and most lesions were located in a high-dose radiation area. Higher blood pressure was associated with CVD and a presence of WMHs. Higher cholesterol levels increased the risk of ischemic infarcts and WMHs, and lower levels of high-density lipoprotein and higher waist circumference increased the risk of lacunar infarcts.ConclusionsTreating CBTs with radiotherapy increases the risk of early CVD and WMHs in young adult survivors. These results suggest an urgent need for investigating CVD prevention in CBT patients.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Suo-Palosaari, Maria HelenaUniv Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland; Univ Oulu, Med Res Ctr Oulu, Oulu, Finland (författare)
  • Koskenkorva, Päivi K. T.Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland (författare)
  • Sutela, Anna K.Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland (författare)
  • Toiviainen-Salo, Sanna-MariaUniv Helsinki, HUS Med Imaging Ctr, Dept Pediat Radiol, Radiol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland (författare)
  • Arikoski, Pekka M.Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland (författare)
  • Arola, Mikko O.Tampere Univ Hosp, Dept Pediat, Tampere, Finland; Univ Tampere, Tampere, Finland (författare)
  • Heikkilä, Vesa-PekkaOulu Univ Hosp, Dept Oncol & Radiotherapy, Oulu, Finland (författare)
  • Kapanen, MikaTampere Univ Hosp, Dept Oncol, Tampere, Finland; Tampere Univ Hosp, Dept Med Phys, Tampere, Finland (författare)
  • Lähteenmäki, Päivi MariaTurku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland; Turku Univ, Turku, Finland (författare)
  • Lönnqvist, Tuula R. I.Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland (författare)
  • Niiniviita, HanneleTurku Univ Hosp, Dept Med Phys, Div Med Imaging, Turku, Finland (författare)
  • Pokka, Tytti M.-L.Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland (författare)
  • Porra, LiisaHelsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Oncol, Helsinki, Finland (författare)
  • Riikonen, V. PekkaUniv Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland (författare)
  • Seppälä, JanKuopio Univ Hosp, Ctr Oncol, Kuopio, Finland (författare)
  • Sirkiä, Kirsti H.Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland (författare)
  • Vanhanen, AnttiTampere Univ Hosp, Dept Oncol, Tampere, Finland; Tampere Univ Hosp, Dept Med Phys, Tampere, Finland (författare)
  • Rantala, Heikki M. J.Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland (författare)
  • Harila-Saari, Arja H.Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)arjha456 (författare)
  • Ojaniemi, Marja K.Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland (författare)
  • Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, FinlandUniv Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland; Univ Oulu, Med Res Ctr Oulu, Oulu, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neuro-Oncology Practice: Oxford University Press (OUP)7:4, s. 415-4272054-25772054-2585

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