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Role of CCCH-Type Z...
Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections
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- Hajikhezri, Zamaneh (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Darweesh, Mahmoud (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Al Azhr Univ, Dept Microbiol & Immunol, Assiut 11651, Egypt
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- Akusjärvi, Göran, 1953- (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Punga, Tanel, PhD, 1974- (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- 2020-11-18
- 2020
- English.
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In: Viruses. - : MDPI AG. - 1999-4915. ; 12:11
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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Abstract
Subject headings
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- The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control different steps of RNA metabolism. Since virus infections interfere with RNA metabolism, dynamic changes in the CCCH-type zinc finger proteins and virus replication are expected to happen. In the present review, we will discuss how three CCCH-type zinc finger proteins, ZC3H11A, MKRN1, and U2AF1, interfere with human adenovirus replication. We will summarize the functions of these three cellular proteins and focus on their potential pro- or anti-viral activities during a lytic human adenovirus infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- human adenovirus
- zinc finger protein
- CCCH-type
- MKRN1
- U2AF1
Publication and Content Type
- ref (subject category)
- for (subject category)
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