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High density of str...
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Corvigno, SaraUppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska University Hospital,Karolinska Inst, Sweden; Uppsala Univ, Sweden
(författare)
High density of stroma-localized CD11c-positive macrophages is associated with longer overall survival in high-grade serous ovarian cancer.
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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Elsevier BV,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-429883
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-429883URI
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https://doi.org/10.1016/j.ygyno.2020.09.041DOI
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https://lup.lub.lu.se/record/5d86aedf-1364-49ba-8da6-194ad5dd11bdURI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173206URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145692462URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Cancer Research Foundations of Radiumhemmet; Swedish Research Council (STARGET Linne grant)Swedish Research Council; Swedish Cancer SocietySwedish Cancer Society; Stockholm City Council
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OBJECTIVE: Pre-clinical studies have identified marker- and tumor compartment-defined functionally distinct macrophage subsets. Our study analyzes marker-defined macrophage subsets in different tumor compartments of high-grade serous ovarian cancer (HGSC).METHODS: A discovery cohort (N = 113) was subjected to immunohistochemistry (IHC) analyses. CD68-positivity was confirmed for CD11c-, CD80- and CD163-positive cells. Subset-marker-positive cells were scored in the total tumor and in four tumor compartments. Correlation analyses investigated co-expression of subsets, relationship to CD8+ cells and survival associations. A validation cohort (N = 121) was used to confirm selected findings from the discovery cohort.RESULTS: CD163-positve cells was the most abundant subtype in all compartments. CD11c and CD163 subsets were strongly correlated with each other in stroma and epithelial areas, whereas CD80 and CD163 were correlated in epithelial areas. CD80 and CD11c in perivascular areas showed low correlations. Strong associations were detected between CD8 and CD80 in the tumor epithelium-dominated areas, and between CD8 and CD11c in stroma areas. High stromal CD11c density was associated with a longer median overall survival in the discovery cohort (HR 0.39; CI 95%, 0.23-0.68; p = 0.001) and in the validation cohort (HR 0.46; CI 95%, 0.22-0.93; p = 0.03).CONCLUSIONS: Our study supports the existence of clinically relevant marker- and localization defined macrophage subsets in HGSC, which are independently regulated. Moreover, it suggests stromal CD11c as a novel prognostic marker in HGSC.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mezheyeuski, ArturUppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska University Hospital,Karolinska Inst, Sweden; Uppsala Univ, Sweden(Swepub:uu)artme913
(författare)
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De La Fuente, Laura MartinLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:lu)med-lrm
(författare)
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Westbom-Fremer, SofiaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:lu)so4231we
(författare)
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Carlson, Joseph WKarolinska Institutet
(författare)
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Fernebro, JosefinUppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Uppsala Univ, Sweden(Swepub:lu)onk-jfe
(författare)
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Åvall Lundqvist, ElisabethLinköpings universitet,Linköping University,Karolinska University Hospital,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Karolinska Inst, Sweden(Swepub:liu)eliav51
(författare)
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Kannisto, PaiviSkåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:lu)gyn-pka
(författare)
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Hedenfalk, IngridLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:lu)onk-ifa
(författare)
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Malander, SusanneLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:lu)onk-sma
(författare)
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Rolny, CharlotteKarolinska Institutet
(författare)
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Dahlstrand, HannaKarolinska Institutet,Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska University Hospital,Karolinska Inst, Sweden; Uppsala Univ, Sweden(Swepub:uu)handa983
(författare)
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Östman, ArneKarolinska Institutet
(författare)
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Uppsala universitetInstitutionen för immunologi, genetik och patologi
(creator_code:org_t)
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Ingår i:Gynecologic Oncology: Elsevier BV159:3, s. 860-8680090-82581095-6859
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