Low-density lipoprotein-cholesterol target attainment according to the 2011 and 2016 ESC/EAS dyslipidaemia guidelines in patients with a recent myocardial infarction: nationwide cohort study, 2013–17

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Allahyari, Ali (author)

Low-density lipoprotein-cholesterol target attainment according to the 2011 and 2016 ESC/EAS dyslipidaemia guidelines in patients with a recent myocardial infarction : nationwide cohort study, 2013–17

Article/chapterEnglish2021

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2020-03-06
Oxford University Press,2021
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LIBRIS-ID:oai:DiVA.org:uu-430294
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430294URI
https://doi.org/10.1093/ehjqcco/qcaa016DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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AIMS: To assess low-density lipoprotein cholesterol (LDL-C) treatment target attainment among myocardial infarction (MI) patients according to the ESC/EAS dyslipidaemia guidelines from 2011 (LDL-C <1.8 mmol/L or ≥ 50% LDL-C reduction) and 2016 (LDL-C <1.8 mmol/L and ≥50% LDL-C reduction).METHODS AND RESULTS: Using nationwide registers, we identified 44,890 patients aged 21-74 admitted for MI, 2013-2017. We included those attending follow-up visits at 6-10 weeks (n = 25,466) and 12-14 months (n = 17,117) after the event. Most patients received high-intensity statin monotherapy (84.3% [6-10 weeks] and 69.0% [12-14 months]) or statins with ezetimibe (2.7% and 10.2%). The proportion of patients attaining the 2011 LDL-C target was 63.8% (6-10 weeks) and 63.5% (12-14 months). The corresponding numbers for the 2016 LDL-C target was 31.6% (6-10 weeks) and 31.5% (12-14 months). At the 6-10-week follow-up, 37% of those not attaining the 2011 LDL-C target and 48% of those not attaining the 2016 target had an LDL-C level that was ≥0.5 mmol/L from the target. When comparing LDL-C measurements performed before vs. after the release of the 2016 guidelines, attainment of the 2016 LDL-C target increased from 30.2% to 35.0% (6-10 weeks) and from 27.6% to 37.6% (12-14 months).CONCLUSIONS: In a nationwide register, one out of three patients with a recent MI had not attained the LDL-C target of the 2011 ESC/EAS guidelines and two out of three patients had not attained the LDL-C target of the 2016 guidelines.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
LDL-cholesterol
ezetimibe
myocardial infarction
statins
target

Added entries (persons, corporate bodies, meetings, titles ...)

Jernberg, Tomas (author)
Lautsch, Dominik (author)
Lundman, Pia (author)
Hagström, EmilUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)emhag677 (author)
Schubert, JessicaUppsala universitet,Kardiologi(Swepub:uu)jesje986 (author)
Boggs, Robert (author)
Salomonsson, Stina (author)
Ueda, Peter (author)
Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

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In:European Heart Journal - Quality of Care and Clinical Outcomes: Oxford University Press7:1, s. 59-672058-52252058-1742

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By the author/editor: Allahyari, Ali; Jernberg, Tomas; Lautsch, Dominik; Lundman, Pia; Hagström, Emil; Schubert, Jessic ...; show more...; Boggs, Robert; Salomonsson, Sti ...; Ueda, Peter; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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By the university: Uppsala University

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