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High-risk human pap...
High-risk human papillomavirus in patients with oral leukoplakia and oral squamous cell carcinoma-A multi-centre study in Sweden, Brazil and Romania.
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- Sundberg, Jonas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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- Öhman, Jenny (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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Korytowska, Magdalena (author)
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- Wallström, Mats (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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- Kjeller, Göran (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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- Andersson, Maria, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Horal, Peter, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Giglio, Daniel, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Kovács, Anikó (author)
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Sand, Lars (author)
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- Hirsch, Jan M. (author)
- Uppsala universitet,Käkkirurgi
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Magda Araújo Ferracini, Lais (author)
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de Souza, Ana Carolina Mamana Fernandes (author)
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Parlatescu, Ioanina (author)
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Dobre, Maria (author)
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Hinescu, Mihail-Eugen (author)
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Braz-Silva, Paulo Henrique (author)
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Tovaru, Serban (author)
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- Hasséus, Bengt, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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(creator_code:org_t)
- 2020-07-16
- 2021
- English.
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In: Oral Diseases. - : Wiley. - 1354-523X .- 1601-0825. ; 27:2, s. 183-192
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Abstract
Subject headings
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- OBJECTIVES: Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC) and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR-HPV in OL has increased over time and whether the prevalence of HR-HPV-positive OL differs in various parts of the world.PATIENTS AND METHODS: A total of 432 patients with OL from Sweden, Brazil and Romania were analysed. Patients were divided into historical (1992-2002) and contemporary (2011-2017) cohorts from the respective countries. Seventeen patients with OL developed oral squamous cell carcinoma (OSCC). A real-time PCR assay, targeting HPV sub-types 6,11,16,18,31,33,35,39,45,52,56,58 and 59, was performed to detect HR-HPV in patients with OL.RESULTS: In the Swedish and Romanian cohorts, none of the investigated HPV sub-types were detected. In the Brazilian cohorts, five patients with OL (3%) were positive for HR-HPV, including four patients from the contemporary cohort (HPV 16, 31, 33) and one from the historical cohort (HPV 11). All the cases of OL that transformed into OSCC were HR-HPV-negative, as were the corresponding tumours.CONCLUSIONS: In summary, the prevalence of HR-HPV in OL is low in all the tested countries, and the incidence has not changed over time. HR-HPV in OL does not seem to be a driver of oncogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- HPV
- PCR
- global variation
- oral cancer
- potentially malignant oral disorders
- virus
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sundberg, Jonas
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Öhman, Jenny
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Korytowska, Magd ...
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Wallström, Mats
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Kjeller, Göran
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Andersson, Maria ...
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show more...
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Horal, Peter, 19 ...
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Lindh, Magnus, 1 ...
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Giglio, Daniel, ...
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Kovács, Anikó
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Sand, Lars
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Hirsch, Jan M.
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Magda Araújo Fer ...
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de Souza, Ana Ca ...
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Parlatescu, Ioan ...
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Dobre, Maria
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Hinescu, Mihail- ...
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Braz-Silva, Paul ...
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Tovaru, Serban
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Hasséus, Bengt, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Oral Diseases
- By the university
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Uppsala University
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University of Gothenburg