Search: (WFRF:(Ahmad Shafqat)) srt2:(2020-2024) >
The interaction of ...
-
Frostdahl, HannaUppsala universitet,Molekylär epidemiologi
(author)
The interaction of genetics and physical activity in the pathogenesis of metabolic dysfunction associated liver disease.
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-535856
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-535856URI
-
https://doi.org/10.1038/s41598-024-68271-4DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Genetic variants associated with increased liver fat and volume have been reported, but whether physical activity (PA) can attenuate the impact of genetic susceptibility to these traits is poorly understood. We aimed to investigate whether higher PA modify genetic impact on liver-related traits in the UK Biobank cohort. PA was self-reported, while magnetic resonance images were used to estimate liver fat (n = 27,243) and liver volume (n = 24,752). Metabolic dysfunction-associated liver disease (MASLD) and chronic liver disease (CLD) were diagnosed using ICD-9 and ICD-10 codes. Ten liver fat and eleven liver volume-associated genetic variants were selected and unweighted genetic-risk scores for liver fat (GRSLF) and liver volume (GRSLV) were computed. Linear regression analyses were performed to explore interactions between GRSLF/ GRSLV and PA in relation to liver-related traits. Association between GRSLF and liver fat was not different among lower (β = 0.063, 95% CI 0.041-0.084) versus higher PA individuals (β = 0.065, 95% CI 0.054-0.077, pinteraction = 0.62). The association between the GRSLV and liver volume was not different across different PA groups (pinteraction = 0.71). Similarly, PA did not modify the effect of GRSLF and GRSLV on MASLD or CLD. Our findings show that physical activity and genetic susceptibility to liver-related phenotypes seem to act independently, benefiting all individuals regardless of genetic risk.
Subject headings and genre
-
CLD
-
Gene-environment interactions
-
IPAQ
-
Liver fat
-
Liver volume
-
MASLD
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ahmad, NoumanUppsala universitet,Radiologi(Swepub:uu)nouah367
(author)
-
Hammar, UlfUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ulfha881
(author)
-
Martínez Mora, AndrésUppsala universitet,Radiologi(Swepub:uu)andma220
(author)
-
Langner, TaroUppsala universitet,Radiologi(Swepub:uu)tarla584
(author)
-
Fall, Tove,1979-Uppsala universitet,Molekylär epidemiologi(Swepub:uu)tovfa878
(author)
-
Kullberg, Joel,1979-Uppsala universitet,Radiologi(Swepub:uu)jokul377
(author)
-
Ahlström, Håkan,1953-Uppsala universitet,Radiologi(Swepub:uu)hakanahl
(author)
-
Brooke, Hannah L.Uppsala universitet,Medicinsk epidemiologi(Swepub:uu)hanbr727
(author)
-
Ahmad, ShafqatUppsala universitet,Molekylär epidemiologi(Swepub:uu)shaah996
(author)
-
Uppsala universitetMolekylär epidemiologi
(creator_code:org_t)
Related titles
-
In:Scientific Reports14:1, s. 17817-2045-2322
Internet link
Find in a library
To the university's database
- By the author/editor
-
Frostdahl, Hanna
-
Ahmad, Nouman
-
Hammar, Ulf
-
Martínez Mora, A ...
-
Langner, Taro
-
Fall, Tove, 1979 ...
-
show more...
-
Kullberg, Joel, ...
-
Ahlström, Håkan, ...
-
Brooke, Hannah L ...
-
Ahmad, Shafqat
-
show less...
- Articles in the publication
-
Scientific Repor ...
- By the university
-
Uppsala University