Search: (WFRF:(Patti Giuseppe)) srt2:(2020) >
Heterogeneity of di...
Heterogeneity of diabetes as a risk factor for major adverse cardiovascular events in anticoagulated patients with atrial fibrillation : an analysis of the ARISTOTLE trial.
-
De Caterina, Raffaele (author)
-
Patti, Giuseppe (author)
-
- Westerbergh, Johan (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
-
show more...
-
Horowitz, John (author)
-
Ezekowitz, Justin A (author)
-
Lewis, Basil S (author)
-
Lopes, Renato D (author)
-
McMurray, John J V (author)
-
Atar, Dan (author)
-
Bahit, M Cecilia (author)
-
Keltai, Matyas (author)
-
López-Sendón, José L (author)
-
Ruzyllo, Witold (author)
-
Granger, Christopher B (author)
-
Alexander, John H (author)
-
- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,UCR
-
show less...
-
(creator_code:org_t)
- 2020-12-28
- 2020
- English.
-
In: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press (OUP). - 2055-6837 .- 2055-6845. ; 8:3, s. 227-235
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- AIMS: Whether diabetes without insulin therapy is an independent cardiovascular (CV) risk factor in atrial fibrillation (AF) has recently been questioned. We investigated the prognostic relevance of diabetes with or without insulin treatment in patients in the ARISTOTLE trial.METHODS AND RESULTS: Patients with AF and increased stroke risk randomized to apixaban vs. warfarin were classified according to diabetes status: no diabetes; diabetes on no diabetes medications; diabetes on non-insulin antidiabetic drugs only; or insulin-treated. The associations between such patient subgroups and stroke/systemic embolism (SE), myocardial infarction (MI), and CV death were examined by Cox proportional hazard regression, both unadjusted and adjusted for other prognostic variables. Patients with diabetes were younger and had a higher body mass index. Median CHA2DS2VASc score was 4.0 in patients with diabetes and 3.0 in patients without diabetes. We found no significant difference in stroke/SE incidence across patient subgroups. Compared with no diabetes, only insulin-treated diabetes was significantly associated with higher risk. When adjusted for clinical variables, compared with no diabetes, the hazard ratios (HRs) for MI (95% confidence intervals) were for diabetes on no medication: 1.15 (0.62-2.14); for diabetes on non-insulin antidiabetic drugs: 1.32 (0.90-1.94); for insulin-treated diabetes: 2.34 (1.43-3.82); interaction P = 0.008. HRs for CV death were for diabetes on no medication: 1.19 (0.86-166); for diabetes on non-insulin antidiabetic drugs: 1.12 (0.88-1.42); for insulin-treated diabetes 1.85 (1.36-2.53), interaction P = 0.001.CONCLUSION: In anticoagulated patients with AF, a higher risk of MI and CV death is largely confined to diabetes treated with insulin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Atrial fibrillation
- Death
- Diabetes
- Insulin
- Myocardial infarction
- Stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
De Caterina, Raf ...
-
Patti, Giuseppe
-
Westerbergh, Joh ...
-
Horowitz, John
-
Ezekowitz, Justi ...
-
Lewis, Basil S
-
show more...
-
Lopes, Renato D
-
McMurray, John J ...
-
Atar, Dan
-
Bahit, M Cecilia
-
Keltai, Matyas
-
López-Sendón, Jo ...
-
Ruzyllo, Witold
-
Granger, Christo ...
-
Alexander, John ...
-
Wallentin, Lars, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
European Heart J ...
- By the university
-
Uppsala University