Search: (WFRF:(Cocca Massimiliano)) >
Meta-analysis uncov...
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
-
- Gorski, Mathias (author)
- University Hospital Regensburg,University of Regensburg
-
Jung, Bettina (author)
-
Li, Yong (author)
-
show more...
-
Matias-Garcia, Pamela R. (author)
-
Wuttke, Matthias (author)
-
Coassin, Stefan (author)
-
Thio, Chris H. L. (author)
-
Kleber, Marcus E. (author)
-
Winkler, Thomas W. (author)
-
Wanner, Veronika (author)
-
Chai, Jin-Fang (author)
-
Chu, Audrey Y. (author)
-
Cocca, Massimiliano (author)
-
Feitosa, Mary F. (author)
-
Ghasemi, Sahar (author)
-
Hoppmann, Anselm (author)
-
Horn, Katrin (author)
-
Li, Man (author)
-
Nutile, Teresa (author)
-
Scholz, Markus (author)
-
Sieber, Karsten B. (author)
-
Teumer, Alexander (author)
-
Tin, Adrienne (author)
-
Wang, Judy (author)
-
Tayo, Bamidele O. (author)
-
Ahluwalia, Tarunveer S. (author)
-
- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Cardiovascular Disease,Cardiovascular Research - Hypertension
-
Bakker, Stephan J. L. (author)
-
Banas, Bernhard (author)
-
Bansal, Nisha (author)
-
Biggs, Mary L. (author)
-
Boerwinkle, Eric (author)
-
Bottinger, Erwin P. (author)
-
Brenner, Hermann (author)
-
Carroll, Robert J. (author)
-
Chalmers, John (author)
-
Chee, Miao-Li (author)
-
Chee, Miao-Ling (author)
-
Cheng, Ching-Yu (author)
-
Coresh, Josef (author)
-
de Borst, Martin H. (author)
-
Degenhardt, Frauke (author)
-
Eckardt, Kai-Uwe (author)
-
Endlich, Karlhans (author)
-
Franke, Andre (author)
-
Freitag-Wolf, Sandra (author)
-
Gampawar, Piyush (author)
-
Gansevoort, Ron T. (author)
-
Ghanbari, Mohsen (author)
-
Gieger, Christian (author)
-
Hamet, Pavel (author)
-
Ho, Kevin (author)
-
Hofer, Edith (author)
-
Holleczek, Bernd (author)
-
Xian Foo, Valencia Hui (author)
-
Hutri-Kähönen, Nina (author)
-
Hwang, Shih-Jen (author)
-
Ikram, M. Arfan (author)
-
Josyula, Navya Shilpa (author)
-
Kähönen, Mika (author)
-
Khor, Chiea-Chuen (author)
-
Koenig, Wolfgang (author)
-
Kramer, Holly (author)
-
Krämer, Bernhard K. (author)
-
Kühnel, Brigitte (author)
-
Lange, Leslie A. (author)
-
Lehtimäki, Terho (author)
-
Lieb, Wolfgang (author)
-
Loos, Ruth J. F. (author)
-
Lukas, Mary Ann (author)
-
Lyytikäinen, Leo-Pekka (author)
-
Meisinger, Christa (author)
-
Meitinger, Thomas (author)
-
- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
-
Milaneschi, Yuri (author)
-
Mishra, Pashupati P. (author)
-
Mononen, Nina (author)
-
Mychaleckyj, Josyf C. (author)
-
Nadkarni, Girish N. (author)
-
Nauck, Matthias (author)
-
Nikus, Kjell (author)
-
Ning, Boting (author)
-
Nolte, Ilja M. (author)
-
O'Donoghue, Michelle L. (author)
-
- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
-
Pendergrass, Sarah A. (author)
-
Penninx, Brenda W. J. H. (author)
-
Preuss, Michael H. (author)
-
Psaty, Bruce M. (author)
-
Raffield, Laura M. (author)
-
Raitakari, Olli T. (author)
-
Rettig, Rainer (author)
-
Rheinberger, Myriam (author)
-
Rice, Kenneth M. (author)
-
Rosenkranz, Alexander R. (author)
-
Rossing, Peter (author)
-
Rotter, Jerome I. (author)
-
Sabanayagam, Charumathi (author)
-
Schmidt, Helena (author)
-
Schmidt, Reinhold (author)
-
Schöttker, Ben (author)
-
Schulz, Christina-Alexandra (author)
-
Sedaghat, Sanaz (author)
-
Shaffer, Christian M. (author)
-
Strauch, Konstantin (author)
-
Szymczak, Silke (author)
-
Taylor, Kent D. (author)
-
Tremblay, Johanne (author)
-
Chaker, Layal (author)
-
van der Harst, Pim (author)
-
van der Most, Peter J. (author)
-
Verweij, Niek (author)
-
Völker, Uwe (author)
-
Waldenberger, Melanie (author)
-
- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
Waterworth, Dawn M. (author)
-
White, Harvey D. (author)
-
Wilson, James G. (author)
-
Wong, Tien-Yin (author)
-
Woodward, Mark (author)
-
Yang, Qiong (author)
-
Yasuda, Masayuki (author)
-
Yerges-Armstrong, Laura M. (author)
-
Zhang, Yan (author)
-
Snieder, Harold (author)
-
Wanner, Christoph (author)
-
Böger, Carsten A. (author)
-
Köttgen, Anna (author)
-
Kronenberg, Florian (author)
-
Pattaro, Cristian (author)
-
- Heid, Iris M. (author)
- University of Regensburg
-
show less...
-
(creator_code:org_t)
-
- Elsevier, 2021
- 2021
- English.
-
In: Kidney International. - : Elsevier. - 0085-2538 .- 1523-1755. ; 99:4, s. 926-939
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
http://www.kidney-in...
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Genome-wide association study
- acute kidney injury
- end-stage kidney disease
- rapid eGFRcrea decline
- Genome-wide association study; acute kidney injury; end-stage kidney disease; rapid eGFRcrea decline.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gorski, Mathias
-
Jung, Bettina
-
Li, Yong
-
Matias-Garcia, P ...
-
Wuttke, Matthias
-
Coassin, Stefan
-
show more...
-
Thio, Chris H. L ...
-
Kleber, Marcus E ...
-
Winkler, Thomas ...
-
Wanner, Veronika
-
Chai, Jin-Fang
-
Chu, Audrey Y.
-
Cocca, Massimili ...
-
Feitosa, Mary F.
-
Ghasemi, Sahar
-
Hoppmann, Anselm
-
Horn, Katrin
-
Li, Man
-
Nutile, Teresa
-
Scholz, Markus
-
Sieber, Karsten ...
-
Teumer, Alexande ...
-
Tin, Adrienne
-
Wang, Judy
-
Tayo, Bamidele O ...
-
Ahluwalia, Tarun ...
-
Almgren, Peter
-
Bakker, Stephan ...
-
Banas, Bernhard
-
Bansal, Nisha
-
Biggs, Mary L.
-
Boerwinkle, Eric
-
Bottinger, Erwin ...
-
Brenner, Hermann
-
Carroll, Robert ...
-
Chalmers, John
-
Chee, Miao-Li
-
Chee, Miao-Ling
-
Cheng, Ching-Yu
-
Coresh, Josef
-
de Borst, Martin ...
-
Degenhardt, Frau ...
-
Eckardt, Kai-Uwe
-
Endlich, Karlhan ...
-
Franke, Andre
-
Freitag-Wolf, Sa ...
-
Gampawar, Piyush
-
Gansevoort, Ron ...
-
Ghanbari, Mohsen
-
Gieger, Christia ...
-
Hamet, Pavel
-
Ho, Kevin
-
Hofer, Edith
-
Holleczek, Bernd
-
Xian Foo, Valenc ...
-
Hutri-Kähönen, N ...
-
Hwang, Shih-Jen
-
Ikram, M. Arfan
-
Josyula, Navya S ...
-
Kähönen, Mika
-
Khor, Chiea-Chue ...
-
Koenig, Wolfgang
-
Kramer, Holly
-
Krämer, Bernhard ...
-
Kühnel, Brigitte
-
Lange, Leslie A.
-
Lehtimäki, Terho
-
Lieb, Wolfgang
-
Loos, Ruth J. F.
-
Lukas, Mary Ann
-
Lyytikäinen, Leo ...
-
Meisinger, Chris ...
-
Meitinger, Thoma ...
-
Melander, Olle
-
Milaneschi, Yuri
-
Mishra, Pashupat ...
-
Mononen, Nina
-
Mychaleckyj, Jos ...
-
Nadkarni, Girish ...
-
Nauck, Matthias
-
Nikus, Kjell
-
Ning, Boting
-
Nolte, Ilja M.
-
O'Donoghue, Mich ...
-
Orho-Melander, M ...
-
Pendergrass, Sar ...
-
Penninx, Brenda ...
-
Preuss, Michael ...
-
Psaty, Bruce M.
-
Raffield, Laura ...
-
Raitakari, Olli ...
-
Rettig, Rainer
-
Rheinberger, Myr ...
-
Rice, Kenneth M.
-
Rosenkranz, Alex ...
-
Rossing, Peter
-
Rotter, Jerome I ...
-
Sabanayagam, Cha ...
-
Schmidt, Helena
-
Schmidt, Reinhol ...
-
Schöttker, Ben
-
Schulz, Christin ...
-
Sedaghat, Sanaz
-
Shaffer, Christi ...
-
Strauch, Konstan ...
-
Szymczak, Silke
-
Taylor, Kent D.
-
Tremblay, Johann ...
-
Chaker, Layal
-
van der Harst, P ...
-
van der Most, Pe ...
-
Verweij, Niek
-
Völker, Uwe
-
Waldenberger, Me ...
-
Wallentin, Lars, ...
-
Waterworth, Dawn ...
-
White, Harvey D.
-
Wilson, James G.
-
Wong, Tien-Yin
-
Woodward, Mark
-
Yang, Qiong
-
Yasuda, Masayuki
-
Yerges-Armstrong ...
-
Zhang, Yan
-
Snieder, Harold
-
Wanner, Christop ...
-
Böger, Carsten A ...
-
Köttgen, Anna
-
Kronenberg, Flor ...
-
Pattaro, Cristia ...
-
Heid, Iris M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Kidney Internati ...
- By the university
-
Uppsala University
-
Lund University