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- Mohammadi, Hanieh (author)
Abdominal obesity and the risk of recurrent atherosclerotic cardiovascular disease after myocardial infarction
- Article/chapterEnglish2020
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- 2020-12-01
- Oxford University Press (OUP),2020
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-431060
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431060URI
- https://doi.org/10.1177/2047487319898019DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:142762430URI
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- Language:English
- Summary in:English
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- BACKGROUND: The association between abdominal obesity and recurrent atherosclerotic cardiovascular disease after myocardial infarction remains unknown.OBJECTIVE: The purpose of this study was to investigate the prevalence of abdominal obesity and its association with recurrent atherosclerotic cardiovascular disease in patients after a first myocardial infarction.DESIGN AND METHODS: In this register-based observational cohort, 22,882 patients were identified from the national Swedish Web-system for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) registry at a clinical revisit 4-10 weeks after their first myocardial infarction 2005-2014. Patients were followed for recurrent atherosclerotic cardiovascular disease defined as non-fatal myocardial infarction, coronary heart disease death, non-fatal or fatal ischaemic stroke. Univariate and multivariable-adjusted Cox regression models were used to calculate hazard ratios and 95% confidence intervals in quintiles of waist circumference as well as three categories of body mass index including normal weight, overweight and obesity.RESULTS: The majority of patients had abdominal obesity. During a median follow-up time of 3.8 years, 1232 men (7.3%) and 469 women (7.9%) experienced a recurrent atherosclerotic cardiovascular disease event. In the univariate analysis, risk was elevated in the fifth quintile (hazard ratio 1.22, 95% confidence interval 1.07-1.39) compared with the first. In the multivariable-adjusted analysis, risk was elevated in the fourth and fifth quintiles (hazard ratio 1.21, confidence interval 1.03-1.43 and hazard ratio 1.25, confidence interval 1.04-1.50), respectively. Gender-stratified analyses showed similar associations in men, while U-shaped associations were observed in women and the body mass index analyses.CONCLUSIONS: Abdominal obesity was common in post-myocardial infarction patients and larger waist circumference was independently associated with recurrent atherosclerotic cardiovascular disease, particularly in men. We recommend utilising waist circumference to identify patients at increased risk of recurrent atherosclerotic cardiovascular disease after myocardial infarction.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
- Waist circumference
- abdominal obesity
- atherosclerotic cardiovascular disease
- body mass index
- myocardial infarction
- secondary prevention
Added entries (persons, corporate bodies, meetings, titles ...)
- Ohm, JoelKarolinska Institutet (author)
- Discacciati, AndreaKarolinska Institutet (author)
- Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi(Swepub:uu)johasund (author)
- Hambraeus, Kristina (author)
- Jernberg, TomasKarolinska Institutet (author)
- Svensson, PerKarolinska Institutet (author)
- Karolinska InstitutetKlinisk epidemiologi (creator_code:org_t)
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- In:European Journal of Preventive Cardiology: Oxford University Press (OUP)27:18, s. 1944-19522047-48732047-4881
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