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TGFBR3L-An Uncharac...
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Sjostedt, EvelinaKarolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden.;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.
(författare)
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-12-31
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BASEL SWITZERLAND :MDPI AG,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-431278
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431278URI
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https://doi.org/10.3390/cancers13010114DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-289514URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145592710URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20210202
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Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for TGFBR3L staining and combined with SF1 and FSH for a 3-plex fluorescent protocol, providing more details about the cell lineage specificity of TGFBR3L expression. A cohort of 230 pituitary neuroendocrine tumours were analysed. In a subgroup of previously characterised gonadotroph tumours, correlation with expression of FSH/LH, E-cadherin, oestrogen (ER) and somatostatin receptors (SSTR) was explored. TGFBR3L showed membranous immunolabeling and was found to be gonadotroph cell lineage-specific, verified by co-expression with SF1 and FSH/LH staining in both tumour and non-neoplastic anterior pituitary tissues. TGFBR3L immunoreactivity was observed in gonadotroph tumours only and demonstrated intra-tumour heterogeneity with a perivascular location. TGFBR3L immunostaining correlated positively to both FSH (R = 0.290) and LH (R = 0.390) immunostaining, and SSTR3 (R = 0.315). TGFBR3L correlated inversely to membranous E-cadherin staining (R = -0.351) and oestrogen receptor β mRNA (R = -0.274). In conclusion, TGFBR3L is a novel pituitary gland specific protein, located in the membrane of gonadotroph cells in non-neoplastic anterior pituitary gland and in a subset of gonadotroph pituitary tumours.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kolnes, Anders JOslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
(författare)
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Olarescu, Nicoleta COslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
(författare)
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Mitsios, NicholasKarolinska Institutet
(författare)
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Hikmet Noraddin, FeriaUppsala universitet,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.(Swepub:uu)ferhi854
(författare)
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Sivertsson, ÅsaKTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u195d5b0
(författare)
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Lindskog, CeciliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.(Swepub:uu)cecli129
(författare)
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Øystese, Kristin A BOslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
(författare)
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Jørgensen, Anders POslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
(författare)
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Bollerslev, JensOslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
(författare)
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Casar Borota, OliveraUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden.;Oslo Univ Hosp, Rikshosp, Dept Pathol, Pb 4950, N-0424 Oslo, Norway.(Swepub:uu)olica753
(författare)
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Karolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden.;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
(creator_code:org_t)
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Ingår i:CancersBASEL SWITZERLAND : MDPI AG13:12072-6694
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Kolnes, Anders J
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Sivertsson, Åsa
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