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  • Sjostedt, EvelinaKarolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden.;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden. (författare)

TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-12-31
  • BASEL SWITZERLAND :MDPI AG,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-431278
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431278URI
  • https://doi.org/10.3390/cancers13010114DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-289514URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145592710URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20210202
  • Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for TGFBR3L staining and combined with SF1 and FSH for a 3-plex fluorescent protocol, providing more details about the cell lineage specificity of TGFBR3L expression. A cohort of 230 pituitary neuroendocrine tumours were analysed. In a subgroup of previously characterised gonadotroph tumours, correlation with expression of FSH/LH, E-cadherin, oestrogen (ER) and somatostatin receptors (SSTR) was explored. TGFBR3L showed membranous immunolabeling and was found to be gonadotroph cell lineage-specific, verified by co-expression with SF1 and FSH/LH staining in both tumour and non-neoplastic anterior pituitary tissues. TGFBR3L immunoreactivity was observed in gonadotroph tumours only and demonstrated intra-tumour heterogeneity with a perivascular location. TGFBR3L immunostaining correlated positively to both FSH (R = 0.290) and LH (R = 0.390) immunostaining, and SSTR3 (R = 0.315). TGFBR3L correlated inversely to membranous E-cadherin staining (R = -0.351) and oestrogen receptor β mRNA (R = -0.274). In conclusion, TGFBR3L is a novel pituitary gland specific protein, located in the membrane of gonadotroph cells in non-neoplastic anterior pituitary gland and in a subset of gonadotroph pituitary tumours.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kolnes, Anders JOslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (författare)
  • Olarescu, Nicoleta COslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (författare)
  • Mitsios, NicholasKarolinska Institutet (författare)
  • Hikmet Noraddin, FeriaUppsala universitet,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.(Swepub:uu)ferhi854 (författare)
  • Sivertsson, ÅsaKTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u195d5b0 (författare)
  • Lindskog, CeciliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.(Swepub:uu)cecli129 (författare)
  • Øystese, Kristin A BOslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (författare)
  • Jørgensen, Anders POslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (författare)
  • Bollerslev, JensOslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (författare)
  • Casar Borota, OliveraUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden.;Oslo Univ Hosp, Rikshosp, Dept Pathol, Pb 4950, N-0424 Oslo, Norway.(Swepub:uu)olica753 (författare)
  • Karolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden.;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:CancersBASEL SWITZERLAND : MDPI AG13:12072-6694

Internetlänk

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  • Cancers (Sök värdpublikationen i LIBRIS)

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