WFRF:(Fløisand Y.)
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- Remberger, MatsUppsala universitet,Hematologi,Oslo University Hospital (author)
The CD34+ Cell Dose Matters in Hematopoietic Stem Cell Transplantation with Peripheral Blood Stem Cells from Sibling Donors
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020
- Springer Science and Business Media LLC,2020
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-431527
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431527URI
- https://doi.org/10.2991/chi.d.200221.001DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:234595446URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The effect of CD34+ cell dose in allogeneic hematopoietic stem cell transplantation (HSCT) on overall survival (OS) and incidence of acute and chronic graft-versus-host disease (GvHD) has not been established and few studies have been performed. Our single center analysis included 189 patients with hematological malignancies who received peripheral blood stem cell (PBSC) grafts from sibling donors. Myeloablative conditioning was used in 88 cases and 101 received reduced intensity conditioning. The median CD34+ cell dose was 5.6 × 106/kg (0.6–17.0). In the multivariate analysis, a CD34 cell dose of 6–7 × 106/kg was associated with better OS and lower transplant-related mortality (TRM), while a dose of <5 × 106/kg led to increased relapse and reduced chronic GVHD (cGVHD). A high CD34 cell-dose (>6.5 × 106/kg) correlated with less acute GVHD (aGVHD) II–IV. We conclude that the CD34 cell dose has an impact on the outcome of HSCT from sibling donor PBSCs.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
- Cell dose
- CD34
- HSCT
- GVHD
- PBSC
- Klinisk immunologi
- Clinical Immunology
Added entries (persons, corporate bodies, meetings, titles ...)
- Grønvold, B. (author)
- Ali, M. (author)
- Mattsson, J.Karolinska Institutet (author)
- Egeland, T. (author)
- Lundin, K. U. (author)
- Myhre, A. (author)
- Abrahamsen, I. (author)
- Heldal, D. (author)
- Dybedal, I. (author)
- Tjønnfjord, G. E. (author)
- Gedde-Dahl, T. (author)
- Fløisand, Y. (author)
- Uppsala universitetHematologi (creator_code:org_t)
Related titles
- In:Clinical Hematology International: Springer Science and Business Media LLC2:2, s. 74-812590-0048
Internet link
- https://doi.org/10.2991/chi.d.200221.001Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1517864/FULLTEXT02.pdffulltext:print
- https://www.atlantis-press.com/article/125935438.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431527
- https://doi.org/10.2991/chi.d.200221.001
- http://kipublications.ki.se/Default.aspx?queryparsed=id:234595446
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- Myhre, A.
- Abrahamsen, I.
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- Fløisand, Y.
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