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Moderators of the e...
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Abrahams, Harriët J. G.
(author)
Moderators of the effect of psychosocial interventions on fatigue in women with breast cancer and men with prostate cancer : Individual patient data meta-analyses
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-09-03
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Wiley,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-431966
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431966URI
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https://doi.org/10.1002/pon.5522DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144540374URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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ObjectivePsychosocial interventions can reduce cancer‐related fatigue effectively. However, it is still unclear if intervention effects differ across subgroups of patients. These meta‐analyses aimed at evaluating moderator effects of (a) sociodemographic characteristics, (b) clinical characteristics, (c) baseline levels of fatigue and other symptoms, and (d) intervention‐related characteristics on the effect of psychosocial interventions on cancer‐related fatigue in patients with non‐metastatic breast and prostate cancer.MethodsData were retrieved from the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) consortium. Potential moderators were studied with meta‐analyses of pooled individual patient data from 14 randomized controlled trials through linear mixed‐effects models with interaction tests. The analyses were conducted separately in patients with breast (n = 1091) and prostate cancer (n = 1008).ResultsStatistically significant, small overall effects of psychosocial interventions on fatigue were found (breast cancer: β = −0.19 [95% confidence interval (95%CI) = −0.30; −0.08]; prostate cancer: β = −0.11 [95%CI = −0.21; −0.00]). In both patient groups, intervention effects did not differ significantly by sociodemographic or clinical characteristics, nor by baseline levels of fatigue or pain. For intervention‐related moderators (only tested among women with breast cancer), statistically significant larger effects were found for cognitive behavioral therapy as intervention strategy (β = −0.27 [95%CI = −0.40; −0.15]), fatigue‐specific interventions (β = −0.48 [95%CI = −0.79; −0.18]), and interventions that only targeted patients with clinically relevant fatigue (β = −0.85 [95%CI = −1.40; −0.30]).ConclusionsOur findings did not provide evidence that any selected demographic or clinical characteristic, or baseline levels of fatigue or pain, moderated effects of psychosocial interventions on fatigue. A specific focus on decreasing fatigue seems beneficial for patients with breast cancer with clinically relevant fatigue.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Knoop, Hans
(author)
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Schreurs, Maartje
(author)
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Aaronson, Neil K.
(author)
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Jacobsen, Paul B.
(author)
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Newton, Robert U.
(author)
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Courneya, Kerry S.
(author)
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Aitken, Joanne F.
(author)
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Arving, CeciliaUppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom(Swepub:uu)ceciarvi
(author)
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Brandberg, YvonneKarolinska Institutet
(author)
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Chambers, Suzanne K.
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Gielissen, Marieke F. M.
(author)
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Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim
(author)
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Goedendorp, Martine M.
(author)
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Graves, Kristi D.
(author)
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Heiney, Sue P.
(author)
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Horne, Rob
(author)
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Hunter, Myra S.
(author)
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Johansson, Birgitta,1959-Uppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)birgjhs
(author)
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Northouse, Laurel L.
(author)
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Oldenburg, Hester S. A.
(author)
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Prins, Judith B.
(author)
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Savard, Josée
(author)
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van Beurden, Marc
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van den Berg, Sanne W.
(author)
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Verdonck-de Leeuw, Irma M.
(author)
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Buffart, Laurien M.
(author)
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Uppsala universitetLivsstil och rehabilitering vid långvarig sjukdom
(creator_code:org_t)
Related titles
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In:Psycho-Oncology: Wiley29:11, s. 1772-17851057-92491099-1611
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Abrahams, Harrië ...
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Knoop, Hans
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Schreurs, Maartj ...
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Aaronson, Neil K ...
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Jacobsen, Paul B ...
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Newton, Robert U ...
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Courneya, Kerry ...
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Aitken, Joanne F ...
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Arving, Cecilia
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Brandberg, Yvonn ...
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Chambers, Suzann ...
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Gielissen, Marie ...
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Glimelius, Bengt
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Goedendorp, Mart ...
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Graves, Kristi D ...
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Heiney, Sue P.
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Horne, Rob
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Hunter, Myra S.
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Johansson, Birgi ...
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Northouse, Laure ...
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Oldenburg, Heste ...
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Prins, Judith B.
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Savard, Josée
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van Beurden, Mar ...
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van den Berg, Sa ...
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Verdonck-de Leeu ...
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Buffart, Laurien ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Psycho-Oncology
- By the university
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Uppsala University
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Karolinska Institutet