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Metabolomic Profile...
Metabolomic Profile in HFpEF vs HFrEF Patients
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- Hage, Camilla (författare)
- Karolinska Institutet
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- Löfgren, Lars (författare)
- AstraZeneca, Biopharmaceut R&D, Translat Sci & Expt Med, Gothenburg, Sweden.;AstraZeneca, Biopharmaceut R&D, Res & Early Dev Cardiovasc Renal & Metab, Gothenburg, Sweden.
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- Michopoulos, Filippos (författare)
- AstraZenenca, Early Oncol R&D, Biosci, Cambridge, England.
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- Nilsson, Ralph (författare)
- AstraZeneca, Biopharmaceut R&D, Translat Sci & Expt Med, Gothenburg, Sweden.;AstraZeneca, Biopharmaceut R&D, Res & Early Dev Cardiovasc Renal & Metab, Gothenburg, Sweden.
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- Davidsson, Pia (författare)
- AstraZeneca, Biopharmaceut R&D, Translat Sci & Expt Med, Gothenburg, Sweden.;AstraZeneca, Biopharmaceut R&D, Res & Early Dev Cardiovasc Renal & Metab, Gothenburg, Sweden.
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- Kumar, Chanchal (författare)
- AstraZeneca, Biopharmaceut R&D, Translat Sci & Expt Med, Gothenburg, Sweden.;AstraZeneca, Biopharmaceut R&D, Res & Early Dev Cardiovasc Renal & Metab, Gothenburg, Sweden.
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- Ekström, Mattias (författare)
- Karolinska Institutet
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- Eriksson, Maria J. (författare)
- Karolinska Institutet
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- Lyngå, Patrik (författare)
- Karolinska Institutet
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- Persson, Bengt (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik
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- Wallén, Hakan (författare)
- Karolinska Institutet
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- Gan, Li Ming (författare)
- AstraZeneca, Biopharmaceut R&D, Early Clin Dev Res & Early Dev Cardiovasc Renal &, Gothenburg, Sweden.
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- Persson, Hans (författare)
- Karolinska Institutet
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- Linde, Cecilia (författare)
- Karolinska Institutet
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Karolinska Institutet AstraZeneca, Biopharmaceut R&D, Translat Sci & Expt Med, Gothenburg, Sweden;AstraZeneca, Biopharmaceut R&D, Res & Early Dev Cardiovasc Renal & Metab, Gothenburg, Sweden. (creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Journal of Cardiac Failure. - : Elsevier BV. - 1071-9164 .- 1532-8414. ; 26:12, s. 1050-1059
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Heart failure with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) are associated with metabolic derangements, which may have different pathophysiological implications.Methods and Results: In new-onset HFpEF (EF of >= 50%, n = 46) and HFrEF (EF of <40%, n = 75) patients, 109 endogenous plasma metabolites including amino acids, phospholipids and acylcarnitines were assessed using targeted metabolomics. Differentially altered metabolites and associations with clinical characteristics were explored. Patients with HFpEF were older, more often female with hypertension, atrial fibrillation, and diabetes compared with patients with HFrEF. Patients with HFpEF displayed higher levels of hydroxyproline and symmetric dimethyl arginine, alanine, cystine, and kynurenine reflecting fibrosis, inflammation and oxidative stress. Serine, cGMP, cAMP, L-carnitine, lysophophatidylcholine (18:2), lactate, and arginine were lower compared with patients with HFrEF. In patients with HFpEF with diabetes, kynurenine was higher (P = .014) and arginine lower (P = .014) vs patients with no diabetes, but did not differ with diabetes status in HFrEF. Decreasing kynurenine was associated with higher eGFR only in HFpEF (P-interaction = .020).Conclusions: Patients with new-onset HFpEF compared with patients with new-onset HFrEF display a different metabolic profile associated with comorbidities, such as diabetes and kidney dysfunction. HFpEF is associated with indices of increased inflammation and oxidative stress, impaired lipid metabolism, increased collagen synthesis, and downregulated nitric oxide signaling. Together, these findings suggest a more predominant systemic microvascular endothelial dysfunction and inflammation linked to increased fibrosis in HFpEF compared with HFrEF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Metabolomics
- HFpEF
- pathophysiology
- microvascular dysfunction
- inflammation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hage, Camilla
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Löfgren, Lars
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Michopoulos, Fil ...
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Nilsson, Ralph
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Davidsson, Pia
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Kumar, Chanchal
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visa fler...
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Ekström, Mattias
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Eriksson, Maria ...
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Lyngå, Patrik
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Persson, Bengt
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Wallén, Hakan
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Gan, Li Ming
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Persson, Hans
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Linde, Cecilia
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of Cardi ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet