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HPV Types in Cervic...
HPV Types in Cervical Precancer by HIV Status and Birth Region : A Population-Based Register Study
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- Carlander, Christina (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Västerås,Karolinska Inst, Infect Dis Unit, Dept Med, Huddinge, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Lagheden, Camilla (author)
- Karolinska Inst, Div Clin Pathol, Dept Lab Med, Stockholm, Sweden.
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- Eklund, Carina (author)
- Karolinska Inst, Div Clin Pathol, Dept Lab Med, Stockholm, Sweden.
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- Kleppe, Sara Nordqvist (author)
- Karolinska Institutet
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- Dzabic, Mensur (author)
- Karolinska Inst, Div Clin Pathol, Dept Lab Med, Stockholm, Sweden.
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- Wagner, Philippe (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Yilmaz, Aylin (author)
- Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis, Gothenburg, Sweden.
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- Elfgren, Kristina (author)
- Karolinska Univ Hosp, CLINTEC, Dept Obstet & Gynaecol, Stockholm, Sweden.
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- Sönnerborg, Anders (author)
- Karolinska Institutet
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- Sparén, Pär (author)
- Karolinska Institutet
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- Dillner, Joakim (author)
- Karolinska Institutet
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(creator_code:org_t)
- AMER ASSOC CANCER RESEARCH, 2020
- 2020
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : AMER ASSOC CANCER RESEARCH. - 1055-9965 .- 1538-7755. ; 29:12, s. 2662-2668
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https://doi.org/10.1...
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Abstract
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- Background: Data are lacking regarding which human papillomavirus (HPV) types cause high-grade cervical neoplasia (CIN2+) in people with HIV in Europe. We assessed which HPV types are associated with CIN2+ in women living in Sweden by HIV status.Methods: The Swedish National HIV Registry, the Swedish Population Registry, and the Swedish National Cervical Screening Registry were linked. CIN2+ tissue blocks of 130 women living with HIV (WLWH) and 234 HIV-negative women, matched for country of birth (1:2), were retrieved from bio-banks and HPV genotyped. Adjusted ORs (adjOR), stratified by country of birth, were calculated using conditional logistic regression. Matching was broken for cross-group comparisons.Results: WLWH with CIN2 were less likely to have HPV16 [14% vs. 40%; adjOR 0.1; 95% confidence interval (CI), 0.04-0.56] than HIV-negative women, but among women with CIN3, there was no difference in HPV16 prevalence by HIV status (adjOR 0.9; 95% CI, 0.51-1.70). WLWH were six times more likely to have HPV35 in CIN3 than HIV-negative women (adjOR 6.2; 95% CI, 1.3-30.4). WLWH from sub-Saharan Africa (SSA) had less 9-valent vaccine types, compared with both HIV-negative women born in Sweden (adjOR 0.1; 95% CI, 0.02-0.44) and WLWH born in Sweden (adjOR 0.1; 95% CI, 0.01-0.73), mostly because of decreased HPV16 and increased HPV35.Conclusions: WLWH from SSA were less likely to be covered by the 9-valent vaccine, mostly due to less HPV16 and more HPV35. Impact: This could have implications for HPV vaccines, currently not including HPV35, and for HPV-screening algorithms in women with origin from SSA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Carlander, Chris ...
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Lagheden, Camill ...
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Eklund, Carina
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Kleppe, Sara Nor ...
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Dzabic, Mensur
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Wagner, Philippe
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Yilmaz, Aylin
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Elfgren, Kristin ...
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Sönnerborg, Ande ...
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Sparén, Pär
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Dillner, Joakim
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Cancer Epidemiol ...
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Uppsala University
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Karolinska Institutet