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Heparan Sulfate Bio...
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Gorniok, Beata FilipekUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Organismal Biol, Sci Life Lab, Uppsala, Sweden.
(author)
Heparan Sulfate Biosynthesis in Zebrafish
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-11-20
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LONDON ENGLAND :SAGE Publications,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-433903
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-433903URI
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https://doi.org/10.1369/0022155420973980DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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The biosynthesis of heparan sulfate (HS) proteoglycans occurs in the Golgi compartment of cells and will determine the sulfation pattern of HS chains, which in turn will have a large impact on the biological activity of the proteoglycans. Earlier studies in mice have demonstrated the importance of HS for embryonic development. In this review, the enzymes participating in zebrafish HS biosynthesis, along with a description of enzyme mutants available for functional studies, are presented. The consequences of the zebrafish genome duplication and maternal transcript contribution are briefly discussed as are the possibilities of CRISPR/Cas9 methodologies to use the zebrafish model system for studies of biosynthesis as well as proteoglycan biology.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Habicher, JudithUppsala universitet,Boije: Zebrafiskens neuronala nätverk,Evolution och utvecklingsbiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Neurosci, Uppsala, Sweden.(Swepub:uu)judha532
(author)
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Ledin, JohanUppsala universitet,Evolution och utvecklingsbiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Organismal Biol, Sci Life Lab, Uppsala, Sweden.(Swepub:uu)joled677
(author)
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Kjellén, LenaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Med Biochem & Microbiol, Sci Life Lab, Uppsala, Sweden.(Swepub:uu)lekje677
(author)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Related titles
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In:Journal of Histochemistry and CytochemistryLONDON ENGLAND : SAGE Publications69:1, s. 49-600022-15541551-5044
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