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  • Durosini, IlariaApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy (author)

Patient Preferences for Lung Cancer Treatment: A Qualitative Study Protocol Among Advanced Lung Cancer Patients

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-02-05
  • Frontiers Media SA,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-434484
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-434484URI
  • https://doi.org/10.3389/fpubh.2021.622154DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction: Lung cancer is the deadliest and most prevalent cancer worldwide. Lung cancer treatments have different characteristics and are associated with a range of benefits and side effects for patients. Such differences may raise uncertainty among drug developers, regulators, payers, and clinicians regarding the value of these treatment effects to patients. The value of conducting patient preference studies (using qualitative and/or quantitative methods) for benefits and side effects of different treatment options has been recognized by healthcare stakeholders, such as drug developers, regulators, health technology assessment bodies, and clinicians. However, evidence-based guidelines on how and when to conduct and use these studies in drug decision-making are lacking. As part of the Innovative Medicines Initiative PREFER project, we developed a protocol for a qualitative study that aims to understand which treatment characteristics are most important to lung cancer patients and to develop attributes and levels for inclusion in a subsequent quantitative preference survey.Methods: The study protocol specifies a four-phased approach: (i) a scoping literature review of published literature, (ii) four focus group discussions with stage III and IV Non-Small Cell Lung Cancer patients, (iii) two nominal group discussions with stage III and IV Non-Small Cell Lung Cancer patients, and (iv) multi-stakeholder discussions involving clinicians and preference experts.Discussion: This protocol outlines methodological and practical steps as to how qualitative research can be applied to identify and develop attributes and levels for inclusion in patient preference studies aiming to inform decisions across the drug life cycle. The results of this study are intended to inform a subsequent quantitative preference survey that assesses patient trade-offs regarding lung cancer treatment options. This protocol may assist researchers, drug developers, and decision-makers in designing qualitative studies to understand which treatment aspects are most valued by patients in drug development, regulation, and reimbursement.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Janssens, RosanneDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium (author)
  • Arnou, ReinhardDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium (author)
  • Veldwijk, JorienSchool of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (author)
  • Smith, Meredith Y.Alexion Pharmaceuticals, Inc., University of Southern California School of Pharmacy, Los Angeles, CA, United States (author)
  • Monzani, DarioApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy (author)
  • Smith, IanJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (author)
  • Galli, GiuliaUnit of Thoracic Oncology, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (author)
  • Garassino, MarinaUnit of Thoracic Oncology, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (author)
  • Katz, Eva G.Janssen Research and Development, Raritan, NJ, United States (author)
  • Bailo, LucaApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy (author)
  • Louis, EvelyneDepartment of Pneumology/Respiratory Oncology, University Hospital Leuven, KU Leuven, Leuven, Belgium (author)
  • Vandevelde, MarieDepartment of Pneumology/Respiratory Oncology, University Hospital Leuven, KU Leuven, Leuven, Belgium (author)
  • Nackaerts, KristiaanDepartment of Pneumology/Respiratory Oncology, University Hospital Leuven, KU Leuven, Leuven, Belgium (author)
  • Ardine de Wit, G.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (author)
  • Pravettoni, GabriellaApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy (author)
  • Huys, IsabelleDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium (author)
  • Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium (creator_code:org_t)

Related titles

  • In:Frontiers In Public Health: Frontiers Media SA92296-2565

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