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Prolonged antithrom...
Prolonged antithrombotic therapy in patients after acute coronary syndrome : A critical appraisal of current European Society of Cardiology guidelines
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- Kubica, Jacek (författare)
- Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, Ul M Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland.
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- Adamski, Piotr (författare)
- Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, Ul M Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland.
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- Niezgoda, Piotr (författare)
- Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, Ul M Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland.
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visa fler...
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- Alexopoulos, Dimitrios (författare)
- Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Athens, Greece.
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- Badariene, Jolita (författare)
- Vilnius Univ, Fac Med, Inst Clin Med, Clin Cardiac & Vasc Dis, Vilnius, Lithuania.
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- Budaj, Andrzej (författare)
- Grochowski Hosp, Ctr Postgrad Med Educ, Dept Cardiol, Warsaw, Poland.
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- Buszko, Katarzyna (författare)
- Nicolaus Copernicus Univ, Dept Theoret Fdn Biomed Sci & Med Informat, Coll Med, Bydgoszcz, Poland.
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- Dudek, Dariusz (författare)
- Jagiellonian Univ, Med Coll, Inst Cardiol, Krakow, Poland.;GVM Care & Res, Maria Cecilia Hosp, Cotignola Ra, Ravenna, Italy.
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- Fabiszak, Tomasz (författare)
- Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, Ul M Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland.
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- Gasior, Mariusz (författare)
- Med Univ Silesia, Fac Med Zabrze, Silesian Ctr Heart Dis, Dept Cardiol 3, Zabrze, Poland.
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- Gil, Robert (författare)
- Internal Affairs & Adm Minist, Ctr Postgrad Med Educ, Dept Invas Cardiol, Cent Hosp, Warsaw, Poland.
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- Gorog, Diana A. (författare)
- Univ Hertfordshire, Postgrad Med, Hatfield, Herts, England.;Imperial Coll, Fac Med, Natl Heart & Lung Inst, London, England.
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- Grajek, Stefan (författare)
- Poznan Univ Med Sci, Dept Cardiol, Poznan, Poland.
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- Gurbel, Paul A. (författare)
- Sinai Hosp, Sinai Ctr Thrombosis Res & Drug Dev, 2401 W Belvedere Ave, Baltimore, MD 21215 USA.
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- Gruchala, Marcin (författare)
- Med Univ Gdansk, Dept Cardiol 1, Gdansk, Poland.
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- Jaguszewski, Milosz J. (författare)
- Med Univ Gdansk, Dept Cardiol 1, Gdansk, Poland.
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- James, Stefan, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Jeong, Young-Hoon (författare)
- Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Chang Won, South Korea.;Gyeongsang Natl Univ, Changwon Hosp, Cardiovasc Ctr, Chang Won, South Korea.
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- Jilma, Bernd (författare)
- Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria.
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- Kasprzak, Jaroslaw D. (författare)
- Med Univ Lodz, Bieganski Hosp, Dept & Chair Cardiol 1, Lodz, Poland.
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- Kleinrok, Andrzej (författare)
- Univ Informat Technol & Management Rzeszow, Rzeszow, Poland.;Pope John Paul II Hosp Zamosc, Dept Cardiol, Zamosc, Poland.
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- Kubica, Aldona (författare)
- Nicolaus Copernicus Univ, Coll Med, Dept Hlth Promot, Bydgoszcz, Poland.
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- Kuliczkowski, Wiktor (författare)
- Med Univ Wroclaw, Dept Cardiol, Wroclaw, Poland.
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- Legutko, Jacek (författare)
- Jagiellonian Univ, John Paul 2 Hosp Krakow, Inst Cardiol, Dept Intervent Cardiol,Med Coll, Krakow, Poland.
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- Lesiak, Maciej (författare)
- Poznan Univ Med Sci, Dept Cardiol, Poznan, Poland.
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- Siller-Matula, Jolanta M. (författare)
- Med Univ Warsaw, Dept Expt & Clin Pharmacol, Warsaw, Poland.;Med Univ Vienna, Dept Cardiol, Vienna, Austria.
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- Nadolny, Klaudiusz (författare)
- Univ Dabrowa Gornicza, Dept Emergency Med Serv, Strateg Planning, Dabrowa Gornicza, Poland.;Katowice Sch Technol, Fac Med, Katowice, Poland.
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- Pstragowski, Krzysztof (författare)
- Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, Ul M Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland.
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- Di Somma, Salvatore (författare)
- Univ Roma La Sapienza, Dept Med Surg Sci & Translat Med, Rome, Italy.
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Specchia, Giuseppe (författare)
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- Stepinska, Janina (författare)
- Natl Inst Cardiol, Dept Intens Cardiac Therapy, Warsaw, Poland.
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- Tantry, Udaya S. (författare)
- Sinai Hosp, Sinai Ctr Thrombosis Res & Drug Dev, 2401 W Belvedere Ave, Baltimore, MD 21215 USA.
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- Tycinska, Agnieszka (författare)
- Med Univ Bialystok, Dept Cardiol, Bialystok, Poland.
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- Verdoia, Monica (författare)
- Univ Piemonte Orientale, Div Cardiol, Osped Infermi ASL Biella, Vercelli, VC, Italy.
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- Wojakowski, Wojciech (författare)
- Med Univ Silesia, Div Cardiol & Struct Heart Dis, Katowice, Poland.
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- Navarese, Eliano P. (författare)
- Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, Ul M Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland.
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Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, Ul M Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Athens, Greece. (creator_code:org_t)
- VM Media SP. zo.o VM Group SK, 2020
- 2020
- Engelska.
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Ingår i: CARDIOLOGY JOURNAL. - : VM Media SP. zo.o VM Group SK. - 1897-5593 .- 1898-018X. ; 27:6, s. 661-676
- Relaterad länk:
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https://doi.org/10.5...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- The increased risk of non-cardiovascular death in patients receiving clopidogrel or prasugrel in comparison with the placebo group in the Dual Antiplatelet Therapy (DAPT) trial in contrast to the decreased risk of cardiovascular death and all-cause death seen in patients treated with low-dose ticagrelor in the EU label population of the PEGASUS-TIMI 54 trial, resulted in inclusion in the 2020 ESC NSTE-ACS guidelines the recommendation for use of clopidogrel or prasugrel only if the patient is not eligible for treatment with ticagrelor. The prevalence of the primary outcome composed of cardiovascular death, stroke, or myocardial infarction was lower in the low-dose rivaroxaban and acetylsalicylic acid (ASA) group than in the ASA-alone group in the COMPASS trial. Moreover, all-cause mortality and cardiovascular mortality rates were lower in the rivaroxaban-plus-ASA group. Comparison of the PEGASUS-TIMI 54 and COMPASS trial patient characteristics clearly shows that each of these treatment strategies should be addressed at different groups of patients. A greater benefit in post-acute coronary syndrome (ACS) patients with a high risk of ischemic events and without high bleeding risk may be expected with ASA and ticagrelor 60 mg b.i.d. when the therapy is continued without interruption or with short interruption only after ACS. On the other hand, ASA and rivaroxaban 2.5 mg b.i.d. seems to be a better option when indications for dual antithrombotic therapy (DATT) appear after a longer time from ACS (more than 2 years) and/or from cessation of DAPT (more than 1 year) and in patients with multiple vascular bed atherosclerosis. Thus, both options of DATTs complement each other rather than compete, as can be presumed from the recommendations. However, a direct comparison between these strategies should be tested in future clinical trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- prolonged antithrombotic therapy
- chronic coronary syndrome
- acute coronary syndrome
- rivaroxaban
- ticagrelor
- clopidogrel
- prasugrel
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- Av författaren/redakt...
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Kubica, Jacek
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Adamski, Piotr
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Niezgoda, Piotr
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Alexopoulos, Dim ...
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Badariene, Jolit ...
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Budaj, Andrzej
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visa fler...
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Buszko, Katarzyn ...
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Dudek, Dariusz
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Fabiszak, Tomasz
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Gasior, Mariusz
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Gil, Robert
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Gorog, Diana A.
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Grajek, Stefan
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Gurbel, Paul A.
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Gruchala, Marcin
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Jaguszewski, Mil ...
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James, Stefan, 1 ...
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Jeong, Young-Hoo ...
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Jilma, Bernd
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Kasprzak, Jarosl ...
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Kleinrok, Andrze ...
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Kubica, Aldona
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Kuliczkowski, Wi ...
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Legutko, Jacek
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Lesiak, Maciej
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Siller-Matula, J ...
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Nadolny, Klaudiu ...
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Pstragowski, Krz ...
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Di Somma, Salvat ...
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Specchia, Giusep ...
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Stepinska, Janin ...
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Tantry, Udaya S.
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Tycinska, Agnies ...
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Verdoia, Monica
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Wojakowski, Wojc ...
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Navarese, Eliano ...
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och Klinisk medicin
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och Kardiologi
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