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ENSAT registry-base...
ENSAT registry-based randomized clinical trials for adrenocortical carcinoma
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- Crona, Joakim (författare)
- Uppsala universitet,Endokrin tumörbiologi
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- Baudin, Eric (författare)
- Univ Paris Saclay, Dept Imagerie, Serv Oncol Endocrinienne, Gustave Roussy, Villejuif, France.
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- Terzolo, Massimo (författare)
- Univ Turin, Dept Clin & Biol Sci, San Luigi Hosp, Orbassano, Italy.
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- Chrisoulidou, Alexandra (författare)
- Theagenio Canc Hosp, Dept Endocrinol, Thessaloniki, Greece.
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- Angelousi, Anna (författare)
- Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Internal Med 1, Unit Endocrinol, Athens, Greece.
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- Ronchi, Cristina L. (författare)
- Univ Birmingham, Inst Metab & Syst Res, Birmingham, W Midlands, England.;Univ Hosp Wurzburg, Div Endocrinol & Diabet, Wurzburg, Germany.
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- Oliveira, Cristina Lamas (författare)
- Complejo Hosp Univ Albacete, Endocrinol Dept, Albacete, Spain.
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- van Dijkum, Els J. M. Nieveen (författare)
- Univ Amsterdam, Canc Ctr Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.
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- Ceccato, Filippo (författare)
- Univ Hosp Padova, Dept Med DIMED, Endocrinol Unit, Padua, Italy.
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- Borson-Chazot, Francoise (författare)
- Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Federat Endocrinol, Lyon, France.
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- Reimondo, Giuseppe (författare)
- Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, Internal Med, Turin, Italy.
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- Tiberi, Guido A. M. (författare)
- Univ Brescia, Dept Clin & Expt Sci, Surg Clin, ASST Spedali Civili, Brescia, Italy.
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- Ettaieb, Hester (författare)
- Maxima Med Ctr, Div Endocrinol, Dept Internal Med, Eindhoven, Netherlands.
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- Kiriakopoulos, Andreas (författare)
- Natl & Kapodistrian Univ Athens, Surg Clin 5, Evgenid Hosp, Sch Med, Athens, Greece.
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- Letizia, Canu (författare)
- Univ Florence, Dept Expt & Clin Biomed Sci, Florence, Italy.
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- Kastelan, Darko (författare)
- Univ Hosp Ctr Zagreb, Dept Endocrinol, Zagreb, Croatia.
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- Osher, Esthr (författare)
- Tel Aviv Univ, Tel Aviv Sourasky Med Ctr Israel, Inst Endocrinol Metab & Hypertens, Sackler Fac Med, Tel Aviv, Israel.
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- Yiannakopoulou, Eugenia (författare)
- Univ West Attica, Dept Biomed Sci, Fac Hlth Sci, Athens, Greece.
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- Arnaldi, Giorgio (författare)
- Polytech Univ Marche, Dept Clin & Mol Sci, Div Endocrinol, Ancona, Italy.
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- Assie, Guillaume (författare)
- Univ Paris, CNRS, Inst Cochin, INSERM, Paris, France.;Hop Cochin, AP HP, Endocrinol, Paris, France.
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- Paiva, Isabel (författare)
- Ctr Hosp & Univ Coimbra, Dept Endocrinol Diabet & Metab, Coimbra, Portugal.
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- Bourdeau, Isabelle (författare)
- Ctr Hosp Univ Montreal CHUM, Dept Med, Res Ctr, Div Endocrinol, Montreal, PQ, Canada.
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- Newell-Price, John (författare)
- Univ Sheffield, Dept Oncol & Metab, Med Sch, Sheffield, S Yorkshire, England.
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- Nowak, Karolina M. (författare)
- Bielanski Hosp, Ctr Postgrad Med Educ, Dept Endocrinol, Warsaw, Poland.
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- Romero, M. Tous (författare)
- Hosp Univ Virgen Macarena, UGC Endocrinol & Nutr, Seville, Spain.
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- De Martino, Maria Cristina (författare)
- Univ Federico II Napoli, Dipartimento Med Clin & Chirurg, Sez Endocrinol, Naples, Italy.
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- Bugalho, Maria Joao (författare)
- CHULN, Serv Endocrinol Diabet & Metabol, Lisbon, Portugal.;Univ Lisbon, Fac Med, Lisbon, Portugal.
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- Sherlock, Mark (författare)
- Beaumont Hosp, Dept Endocrinol, Dublin, Ireland.;Royal Coll Surgeons Ireland, Dublin, Ireland.
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- Vantyghem, Marie-Christine (författare)
- Lille Univ Hosp, Endocrinol Diabetol Metab & Nutr Dept, Lille, France.
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- Dennedy, Michael Conall (författare)
- Natl Univ Ireland, Dept Endocrinol & Diabet Mellitus, Dept Med, Clin Sci Inst, Galway, Ireland.
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- Loli, Paula (författare)
- Osped Niguarda Ca Granda, Endocrinol, Naples, Italy.
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- Rodien, Patrice (författare)
- CHU Angers, Serv Endocrinol Diabetol & Nutr, Angers 9, France.
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- Feelders, Richard (författare)
- Erasmus MC, Div Endocrinol, Dept Internal Med, Rotterdam, Netherlands.
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- de Krijger, Ronald (författare)
- Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands.;Univ Med Ctr, Dept Pathol, Utrecht, Netherlands.
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- Van Slycke, Sam (författare)
- OLV Hosp Aalst, Gen & Endocrine Surg, Aalst, Belgium.
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- Aylwin, Simon (författare)
- Kings Coll Hosp London, London, England.
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- Morelli, Valentina (författare)
- Osped Maggiore Policlin, Endocrinol Unit, Fdn IRCCS Ca Granda, Milan, Italy.
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- Vroonen, Laurent (författare)
- Ctr Hosp Univ Liege, Dept Endocrinol, Liege, Belgium.
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- Shafigullina, Zulfiya (författare)
- North Western Med Univ, Endocrinol Dept, St Petersburg, Russia.
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- Bancos, Irina (författare)
- Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN USA.
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- Trofimiuk-Mueldner, Malgorzata (författare)
- Jagiellonian Univ Med Coll, Dept Endocrinol, Krakow, Poland.
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- Quinkler, Marcus (författare)
- Endocrinol Charlottenburg, Berlin, Germany.
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- Luconi, Michaela (författare)
- Univ Florence, Dept Expt & Clin Biomed Sci, Florence, Italy.
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- Kroiss, Matthias (författare)
- Univ Hosp Wurzburg, Div Endocrinol & Diabet, Wurzburg, Germany.;Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Wurzburg, Germany.
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- Naruse, Mitsuhide (författare)
- Ijinkai Takeda Gen Hosp, Endocrine Ctr, Kyoto, Japan.;NHO Kyoto Med Ctr, Clin Res Inst Endocrinol & Metab, Kyoto, Japan.
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- Igaz, Peter (författare)
- Semmelweis Univ, Dept Internal Med 2, Budapest, Hungary.;Hungarian Acad Sci, MTA SE Mol Med Res Grp, Budapest, Hungary.;Semmelweis Univ, Budapest, Hungary.
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- Mihai, Radu (författare)
- Univ Oxford, Dept Endocrine Surg, Churchill Canc Ctr, Oxford, England.
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- Della Casa, Silvia (författare)
- Catholic Univ, Endocrinol Dept, Gemelli Polyclin Fdn, Rome, Italy.
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- Berruti, Alfredo (författare)
- Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Med Oncol,ASST Spedali Civili, Brescia, Italy.
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- Fassnacht, Martin (författare)
- Univ Hosp Wurzburg, Div Endocrinol & Diabet, Wurzburg, Germany.;Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Wurzburg, Germany.
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- Beuschlein, Felix (författare)
- Univ Spital Zurich, Klin Endokrinol Diabetol & Klin Ernahrung, Zurich, Switzerland.;Klinikum Univ Munchen, Deptr Endocrinol, Med Klin & Poliklin 4, Munich, Germany.
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(creator_code:org_t)
- Bioscientifica, 2021
- 2021
- Engelska.
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Ingår i: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 184:2, s. R51-R59
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Crona, Joakim
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Baudin, Eric
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Terzolo, Massimo
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Chrisoulidou, Al ...
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Angelousi, Anna
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Ronchi, Cristina ...
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visa fler...
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Oliveira, Cristi ...
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van Dijkum, Els ...
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Ceccato, Filippo
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Borson-Chazot, F ...
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Reimondo, Giusep ...
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Tiberi, Guido A. ...
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Ettaieb, Hester
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Kiriakopoulos, A ...
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Letizia, Canu
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Kastelan, Darko
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Osher, Esthr
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Yiannakopoulou, ...
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Arnaldi, Giorgio
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Assie, Guillaume
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Paiva, Isabel
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Bourdeau, Isabel ...
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Newell-Price, Jo ...
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Nowak, Karolina ...
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Romero, M. Tous
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De Martino, Mari ...
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Bugalho, Maria J ...
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Sherlock, Mark
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Vantyghem, Marie ...
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Dennedy, Michael ...
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Loli, Paula
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Rodien, Patrice
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Feelders, Richar ...
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de Krijger, Rona ...
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Van Slycke, Sam
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Aylwin, Simon
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Morelli, Valenti ...
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Vroonen, Laurent
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Shafigullina, Zu ...
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Bancos, Irina
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Trofimiuk-Mueldn ...
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Quinkler, Marcus
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Luconi, Michaela
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Kroiss, Matthias
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Naruse, Mitsuhid ...
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Igaz, Peter
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Mihai, Radu
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Della Casa, Silv ...
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Berruti, Alfredo
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Fassnacht, Marti ...
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Beuschlein, Feli ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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European Journal ...
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Uppsala universitet