Diabetes exacerbates brain pathology following a focal blast brain injury: New role of a multimodal drug cerebrolysin and nanomedicine

Muresanu, Dafin F.Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania. (författare)

Diabetes exacerbates brain pathology following a focal blast brain injury : New role of a multimodal drug cerebrolysin and nanomedicine

Blast brain injury (bBI) is a combination of several forces of pressure, rotation, penetration of sharp objects and chemical exposure causing laceration, perforation and tissue losses in the brain. The bBI is quite prevalent in military personnel during combat operations. However, no suitable therapeutic strategies are available so far to minimize bBI pathology. Combat stress induces profound cardiovascular and endocrine dysfunction leading to psychosomatic disorders including diabetes mellitus (DM). This is still unclear whether brain pathology in bBI could exacerbate in DM. In present review influence of DM on pathophysiology of bBI is discussed based on our own investigations. In addition, treatment with cerebrolysin (a multimodal drug comprising neurotrophic factors and active peptide fragments) or H-290/51 (a chain-breaking antioxidant) using nanowired delivery of for superior neuroprotection on brain pathology in bBI in DM is explored. Our observations are the first to show that pathophysiology of bBI is exacerbated in DM and TiO2-nanowired delivery of cerebrolysin induces profound neuroprotection in bBI in DM, not reported earlier. The clinical significance of our findings with regard to military medicine is discussed.

Sharma, ArunaUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)arush975 (författare)
Sahib, SeaabUniv Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA. (författare)
Tian, Z. RyanUniv Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA. (författare)
Feng, LianyuanBethune Int Peace Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China. (författare)
Castellani, Rudy J.Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA. (författare)
Nozari, AlaMassachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA. (författare)
Vicente Lafuente, JoseUniv Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Bizkaia, Spain. (författare)
Buzoianu, Anca D.Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania. (författare)
Sjoquist, Per-OveKarolinska Univ Hosp, Karolinska Inst, Dept Med, Div Cardiol, Stockholm, Sweden. (författare)
Patnaik, RanjanaBanaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Dept Biomat, Varanasi, Uttar Pradesh, India. (författare)
Wiklund, LarsUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)larswikl (författare)
Sharma, Hari ShankerUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)hssharma (författare)
Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.Anestesiologi och intensivvård (creator_code:org_t)

Ingår i:Neuropharmacology of Neuroprotection: ELSEVIER258, s. 285-3679780128208137
Ingår i:Progress in brain research: ELSEVIER258, s. 285-3671875-7855

Av författaren/redakt...: Muresanu, Dafin ...; Sharma, Aruna; Sahib, Seaab; Tian, Z. Ryan; Feng, Lianyuan; Castellani, Rudy ...; visa fler...; Nozari, Ala; Vicente Lafuente ...; Buzoianu, Anca D ...; Sjoquist, Per-Ov ...; Patnaik, Ranjana; Wiklund, Lars; Sharma, Hari Sha ...; visa färre...

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