Sökning: WFRF:(Lopez Otin Carlos) >
The proliferative h...
-
Duran-Ferrer, MartiInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
(författare)
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
-
2020-11-02
-
Springer Nature,2020
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-436028
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-436028URI
-
https://doi.org/10.1038/s43018-020-00131-2DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
We report a systematic analysis of the DNA methylation variability in 1,595 samples of normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell lineage. Differential methylation among tumor entities relates to differences in cellular origin and to de novo epigenetic alterations, which allowed us to build an accurate machine learning-based diagnostic algorithm. We identify extensive individual-specific methylation variability in silenced chromatin associated with the proliferative history of normal and neoplastic B cells. Mitotic activity generally leaves both hyper- and hypomethylation imprints, but some B-cell neoplasms preferentially gain or lose DNA methylation. We construct a DNA-methylation-based mitotic clock, called epiCMIT, whose lapse magnitude represents a strong independent prognostic variable in B-cell tumors and is associated with particular driver genetic alterations. Our findings reveal DNA methylation as a holistic tracer of B-cell tumor developmental history, with implications in differential diagnosis and the prediction of clinical outcome. Martin-Subero and colleagues analyze DNA methylation patterns in B-cell tumors and their normal cells of origin, and develop epiCMIT, a methylation-based mitotic clock with prognostic relevance.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Clot, GuillemInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
(författare)
-
Nadeu, FerranInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
(författare)
-
Beekman, ReneeInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
(författare)
-
Baumann, TychoCIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
(författare)
-
Nordlund, JessicaUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)jesno775
(författare)
-
Marincevic-Zuniga, YanaraUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)yanma214
(författare)
-
Lönnerholm, Gudmar,1941-Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)gudmarlh
(författare)
-
Rivas-Delgado, AlfredoInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
(författare)
-
Martin, SilviaInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
(författare)
-
Ordonez, RaquelCIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.
(författare)
-
Castellano, GiancarloInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
(författare)
-
Kulis, MartaInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
(författare)
-
Queiros, Ana C.Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
(författare)
-
Lee, Seung-TaeYonsei Univ, Coll Med, Dept Lab Med, Seoul, South Korea.
(författare)
-
Wiemels, JosephUniv Southern Calif, Ctr Genet Epidemiol, Los Angeles, CA 90007 USA.
(författare)
-
Royo, RominaUniv Barcelona, Spanish Natl Bioinformat Inst, Inst Recerca Biomed IRB, Programa Conjunto Biol Computac,Barcelona Superco, Barcelona, Spain.
(författare)
-
Puiggros, MontserratUniv Barcelona, Spanish Natl Bioinformat Inst, Inst Recerca Biomed IRB, Programa Conjunto Biol Computac,Barcelona Superco, Barcelona, Spain.
(författare)
-
Lu, JunyanEuropean Mol Biol Lab EMBL, Heidelberg, Germany.
(författare)
-
Gine, EvaInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
(författare)
-
Bea, SilviaInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
(författare)
-
Jares, PedroInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
(författare)
-
Agirre, XabierCIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.
(författare)
-
Prosper, FelipeCIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.;Univ Navarra, Clin Univ Navarra, Hematol & Cell Therapy Dept, Pamplona, Spain.
(författare)
-
Lopez-Otin, CarlosCIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, Oviedo, Spain.
(författare)
-
Puente, Xose S.CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, Oviedo, Spain.
(författare)
-
Oakes, Christopher C.Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
(författare)
-
Zenz, ThorstenOhio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.;Univ Hosp Zurich, Dept Med Oncol & Hematol, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland.
(författare)
-
Delgado, JulioInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
(författare)
-
Lopez-Guillermo, ArmandoInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
(författare)
-
Campo, EliasInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Fonaments Clin, Barcelona, Spain.
(författare)
-
Ignacio Martin-Subero, JoseInst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Fonaments Clin, Barcelona, Spain.;Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain.
(författare)
-
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:NATURE CANCER: Springer Nature1:11, s. 1066-10812662-1347
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Duran-Ferrer, Ma ...
-
Clot, Guillem
-
Nadeu, Ferran
-
Beekman, Renee
-
Baumann, Tycho
-
Nordlund, Jessic ...
-
visa fler...
-
Marincevic-Zunig ...
-
Lönnerholm, Gudm ...
-
Rivas-Delgado, A ...
-
Martin, Silvia
-
Ordonez, Raquel
-
Castellano, Gian ...
-
Kulis, Marta
-
Queiros, Ana C.
-
Lee, Seung-Tae
-
Wiemels, Joseph
-
Royo, Romina
-
Puiggros, Montse ...
-
Lu, Junyan
-
Gine, Eva
-
Bea, Silvia
-
Jares, Pedro
-
Agirre, Xabier
-
Prosper, Felipe
-
Lopez-Otin, Carl ...
-
Puente, Xose S.
-
Oakes, Christoph ...
-
Zenz, Thorsten
-
Delgado, Julio
-
Lopez-Guillermo, ...
-
Campo, Elias
-
Ignacio Martin-S ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
NATURE CANCER
- Av lärosätet
-
Uppsala universitet