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Potential synergy b...
Potential synergy between PSMA uptake and tumour blood flow for prediction of human prostate cancer aggressiveness
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- Jochumsen, Mads Ryo (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.;Viborg Reg Hosp, Dept Radiol, Viborg, Denmark.
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi,Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
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- Tolbod, Lars Poulsen (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
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- Pedersen, Bodil Ginnerup (författare)
- Aarhus Univ, Dept Clin Med, Aarhus, Denmark.;Aarhus Univ Hosp, Dept Radiol, Aarhus, Denmark.
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- Frokiaer, Jorgen (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
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- Borre, Michael (författare)
- Aarhus Univ, Dept Clin Med, Aarhus, Denmark.;Aarhus Univ Hosp, Dept Urol, Aarhus, Denmark.
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- Bouchelouche, Kirsten (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
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Aarhus Univ Hosp, Dept Nucl Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark;Aarhus Univ Hosp, PET Ctr, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.;Viborg Reg Hosp, Dept Radiol, Viborg, Denmark. Radiologi (creator_code:org_t)
- 2021-02-09
- 2021
- Engelska.
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Ingår i: EJNMMI Research. - : Springer Nature. - 2191-219X. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://ejnmmires.sp...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Both prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressiveness. The aim of the present study was to evaluate the potential synergistic benefit of combining the two physiologic parameters for separating significant PCa from insignificant findings. Methods From previous studies of [Rb-82]Rb positron emission tomography (PET) TBF in PCa, the 43 patients that underwent clinical [Ga-68]Ga-PSMA-11 PET were selected for this retrospective study. Tumours were delineated on [Ga-68]Ga-PSMA-11 PET or magnetic resonance imaging. ISUP GG was recorded from 52 lesions. Results [Ga-68]Ga-PSMA-11 maximum standardized uptake value (SUVmax) and [Rb-82]Rb SUVmax correlated moderately with ISUP GG (rho = 0.59 and rho = 0.56, both p < 0.001) and with each other (r = 0.65, p < 0.001). A combined model of [Ga-68]Ga-PSMA-11 and [Rb-82]Rb SUVmax separated ISUP GG > 2 from ISUP GG 1-2 and benign with an area-under-the-curve of 0.85, 96% sensitivity, 74% specificity, and 95% negative predictive value. The combined model performed significantly better than either tracer alone did (p < 0.001), primarily by reducing false negatives from five or six to one (p <= 0.025). Conclusion PSMA uptake and TBF provide complementary information about tumour aggressiveness. We suggest that a combined analysis of PSMA uptake and TBF could significantly improve the negative predictive value and allow non-invasive separation of significant from insignificant PCa.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Prostate cancer
- PSMA
- Tumour blood flow
- Rubidium
- ISUP grade group
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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