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Profiling Persisten...
Profiling Persistent Asthma Phenotypes in Adolescents : A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies
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- Amaral, Rita (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;Polytech Inst Porto, Porto Hlth Sch, Dept Cardiovasc & Resp Sci, P-4200072 Porto, Portugal.;Uppsala Univ, Dept Womens & Childrens Hlth, Paediat Res, SE-75105 Uppsala, Sweden.
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- Jacome, Cristina (author)
- Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.
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- Almeida, Rute (author)
- Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.
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- Pereira, Ana Margarida (author)
- Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;CUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
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- Alves-Correia, Magna (author)
- CUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
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- Mendes, Sandra (author)
- Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.
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- Rodrigues, Jose Carlos Cidrais (author)
- Hosp Pedro Hispano, Serv Pediat, Unidade Local Saude Matosinhos, P-4464513 Matosinhos, Portugal.
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- Carvalho, Joana (author)
- Hosp Pedro Hispano, Serv Pediat, Unidade Local Saude Matosinhos, P-4464513 Matosinhos, Portugal.
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- Araujo, Luis (author)
- CUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
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- Costa, Alberto (author)
- Hosp Senhora Oliveira, Serv Pediat, P-4835044 Guimaraes, Portugal.
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- Silva, Armandina (author)
- Hosp Senhora Oliveira, Serv Pediat, P-4835044 Guimaraes, Portugal.
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- Teixeira, Maria Fernanda (author)
- Ctr Hosp Univ Porto, Ctr Materno Infantil Norte, Serv Pediat, P-4099001 Porto, Portugal.
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- Ferreira-Magalhaes, Manuel (author)
- Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;Ctr Hosp Univ Porto, Ctr Materno Infantil Norte, Serv Pediat, P-4099001 Porto, Portugal.
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- Alves, Rodrigo Rodrigues (author)
- Hosp Div Espirito Santo, Serv Imunoalergol, P-9500370 Ponta Delgada, Portugal.
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- Moreira, Ana Sofia (author)
- Hosp Divino Espirito Santo, Unidade Imunoalergol, P-9500370 Ponta Delgada, Portugal.
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- Fernandes, Ricardo M. (author)
- Ctr Hosp Lisboa Norte, Hosp Santa Maria, Dept Pediat, P-1649035 Lisbon, Portugal.
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- Ferreira, Rosario (author)
- Ctr Hosp Lisboa Norte, Hosp Santa Maria, Dept Pediat, P-1649035 Lisbon, Portugal.
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- Pinto, Paula Leiria (author)
- Ctr Hosp Univ Lisboa Cent, Hosp Dona Estefania, Serv Imunoalergol, P-1150199 Lisbon, Portugal.
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- Neuparth, Nuno (author)
- Ctr Hosp Univ Lisboa Cent, Hosp Dona Estefania, Serv Imunoalergol, P-1150199 Lisbon, Portugal.;Nova Med Sch, CHRC CEDOC, Pathophysiol, P-1150190 Lisbon, Portugal.
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- Bordalo, Diana (author)
- Ctr Hosp Medio Ave, Unidade Hosp Famalicao, Serv Pediat, P-4780371 Vila Nova De Famalicao, Portugal.
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- Bom, Ana Todo (author)
- Ctr Hosp & Univ Coimbra, Serv Imunoalergol, P-3000075 Coimbra, Portugal.
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- Calix, Maria Jose (author)
- Hosp Sao Teotonio, Ctr Hosp Tondela Viseu, Serv Pediat, P-3504509 Viseu, Portugal.
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- Ferreira, Tania (author)
- ACeS Baixo Mondego, Unidade Saude Familiar Progresso & Saude, P-3060716 Tocha, Portugal.
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- Gomes, Joana (author)
- Ctr Hosp Vila Nova Gaia Espinho, Unidade 1, Serv Imunoalergol, P-4434502 Vila Nova De Gaia, Portugal.
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- Vidal, Carmen (author)
- Complejo Hosp Univ Santiago, Serv Alergia, Santiago De Compostela 15706, Spain.
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- Mendes, Ana (author)
- Ctr Hosp Lisboa Norte, Hosp Santa Maria, Dept Pediat, P-1649035 Lisbon, Portugal.
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- Vasconcelos, Maria Joao (author)
- Ctr Hosp Univ Sao Joao, Serv Imunoalergol, P-4200319 Porto, Portugal.
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- Silva, Pedro Morais (author)
- Grp HPA Saude, Imunoalergol, P-8500322 Portimao, Portugal.
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- Ferraz, Jose (author)
- Hosp Privado Alfena, Imunoalergol, P-4445243 Trofa Saude, Alfena, Portugal.
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- Morete, Ana (author)
- Hosp Infante D Pedro, Ctr Hosp Baixo Vouga, Serv Imunoalergol, P-3814501 Aveiro, Portugal.
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- Pinto, Claudia Sofia (author)
- Hosp Sao Pedro Vila Real, Ctr Hosp Tras Os Montes E Alto Douro, Serv Pneumol, P-5000508 Vila Real, Portugal.
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- Santos, Natacha (author)
- Ctr Hosp Univ Algarve, Serv Imunoalergol, P-8000386 Portimao, Portugal.
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- Loureiro, Claudia Chaves (author)
- Hosp Univ Coimbra, Serv Pneumol, P-3000076 Coimbra, Portugal.
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- Arrobas, Ana (author)
- Ctr Hosp & Univ Coimbra, Serv Pneumol, P-3000075 Coimbra, Portugal.
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- Marques, Maria Luis (author)
- Ctr Hosp Univ Porto, Serv Imunoalergol, P-4099001 Porto, Portugal.
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- Lozoya, Carlos (author)
- Hosp Amato Lusitano, Unidade Local Saude Castelo Branco, Serv Imunoalergol, P-6000085 Castelo Branco, Portugal.
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- Lopes, Cristina (author)
- Hosp Pedro Hispano, Serv Pediat, Unidade Local Saude Matosinhos, P-4464513 Matosinhos, Portugal.;Univ Porto, Fac Med, Imunol Basica & Clin, P-4200319 Porto, Portugal.
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- Cardia, Francisca (author)
- ACES Dao Lafoes, Unidade Saude Familiar Terras Azurara, P-3530113 Mangualde, Portugal.
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- Loureiro, Carla Chaves (author)
- Ctr Hosp & Univ Coimbra, Dept Pediat, Serv Pediat Ambulatoria, P-3000075 Coimbra, Portugal.
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- Camara, Raquel (author)
- Hosp Nossa Senhora Rosario, Ctr Hosp Barreiro Montijo, Serv Pneumol, P-2834003 Barreiro, Portugal.
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- Vieira, Ines (author)
- ACES Pinhal Litoral, UCSP Dr Arnaldo Sampaio, P-2419014 Leiria, Portugal.
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- da Silva, Sofia (author)
- USF Cuidarte, Unidade Local Saude Alto Minho, P-4925083 Portuzelo, Portugal.
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- Silva, Eurico (author)
- ACeS Baixo Vouga, Unidade Saude Familiar Joao Semana, P-3880225 Ovar, Portugal.
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- Rodrigues, Natalina (author)
- ACES Baixo Mondego, Unidade Saude Familiar Mondego, P-3045059 Coimbra, Portugal.
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- Fonseca, Joao A. (author)
- Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;CUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
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(creator_code:org_t)
- 2021-01-24
- 2021
- English.
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In: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:3
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
Close
- We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- asthma
- adolescents
- phenotypes
- clustering
- longitudinal studies
- latent class analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Amaral, Rita
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Jacome, Cristina
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Almeida, Rute
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Pereira, Ana Mar ...
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Alves-Correia, M ...
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Mendes, Sandra
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show more...
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Rodrigues, Jose ...
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Carvalho, Joana
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Araujo, Luis
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Costa, Alberto
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Silva, Armandina
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Teixeira, Maria ...
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Ferreira-Magalha ...
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Alves, Rodrigo R ...
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Moreira, Ana Sof ...
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Fernandes, Ricar ...
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Ferreira, Rosari ...
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Pinto, Paula Lei ...
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Neuparth, Nuno
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Bordalo, Diana
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Bom, Ana Todo
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Calix, Maria Jos ...
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Ferreira, Tania
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Gomes, Joana
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Vidal, Carmen
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Mendes, Ana
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Vasconcelos, Mar ...
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Silva, Pedro Mor ...
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Ferraz, Jose
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Morete, Ana
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Pinto, Claudia S ...
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Santos, Natacha
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Loureiro, Claudi ...
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Arrobas, Ana
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Marques, Maria L ...
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Lozoya, Carlos
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Lopes, Cristina
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Cardia, Francisc ...
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Loureiro, Carla ...
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Camara, Raquel
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Vieira, Ines
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da Silva, Sofia
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Silva, Eurico
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Rodrigues, Natal ...
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Fonseca, Joao A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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International Jo ...
- By the university
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Uppsala University