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Profiling Persisten...
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Amaral, RitaUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;Polytech Inst Porto, Porto Hlth Sch, Dept Cardiovasc & Resp Sci, P-4200072 Porto, Portugal.;Uppsala Univ, Dept Womens & Childrens Hlth, Paediat Res, SE-75105 Uppsala, Sweden.
(författare)
Profiling Persistent Asthma Phenotypes in Adolescents : A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-01-24
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MDPI,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-437450
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-437450URI
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https://doi.org/10.3390/ijerph18031015DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jacome, CristinaUniv Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.
(författare)
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Almeida, RuteUniv Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.
(författare)
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Pereira, Ana MargaridaUniv Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;CUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
(författare)
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Alves-Correia, MagnaCUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
(författare)
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Mendes, SandraUniv Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.
(författare)
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Rodrigues, Jose Carlos CidraisHosp Pedro Hispano, Serv Pediat, Unidade Local Saude Matosinhos, P-4464513 Matosinhos, Portugal.
(författare)
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Carvalho, JoanaHosp Pedro Hispano, Serv Pediat, Unidade Local Saude Matosinhos, P-4464513 Matosinhos, Portugal.
(författare)
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Araujo, LuisCUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
(författare)
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Costa, AlbertoHosp Senhora Oliveira, Serv Pediat, P-4835044 Guimaraes, Portugal.
(författare)
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Silva, ArmandinaHosp Senhora Oliveira, Serv Pediat, P-4835044 Guimaraes, Portugal.
(författare)
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Teixeira, Maria FernandaCtr Hosp Univ Porto, Ctr Materno Infantil Norte, Serv Pediat, P-4099001 Porto, Portugal.
(författare)
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Ferreira-Magalhaes, ManuelUniv Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;Ctr Hosp Univ Porto, Ctr Materno Infantil Norte, Serv Pediat, P-4099001 Porto, Portugal.
(författare)
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Alves, Rodrigo RodriguesHosp Div Espirito Santo, Serv Imunoalergol, P-9500370 Ponta Delgada, Portugal.
(författare)
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Moreira, Ana SofiaHosp Divino Espirito Santo, Unidade Imunoalergol, P-9500370 Ponta Delgada, Portugal.
(författare)
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Fernandes, Ricardo M.Ctr Hosp Lisboa Norte, Hosp Santa Maria, Dept Pediat, P-1649035 Lisbon, Portugal.
(författare)
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Ferreira, RosarioCtr Hosp Lisboa Norte, Hosp Santa Maria, Dept Pediat, P-1649035 Lisbon, Portugal.
(författare)
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Pinto, Paula LeiriaCtr Hosp Univ Lisboa Cent, Hosp Dona Estefania, Serv Imunoalergol, P-1150199 Lisbon, Portugal.
(författare)
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Neuparth, NunoCtr Hosp Univ Lisboa Cent, Hosp Dona Estefania, Serv Imunoalergol, P-1150199 Lisbon, Portugal.;Nova Med Sch, CHRC CEDOC, Pathophysiol, P-1150190 Lisbon, Portugal.
(författare)
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Bordalo, DianaCtr Hosp Medio Ave, Unidade Hosp Famalicao, Serv Pediat, P-4780371 Vila Nova De Famalicao, Portugal.
(författare)
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Bom, Ana TodoCtr Hosp & Univ Coimbra, Serv Imunoalergol, P-3000075 Coimbra, Portugal.
(författare)
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Calix, Maria JoseHosp Sao Teotonio, Ctr Hosp Tondela Viseu, Serv Pediat, P-3504509 Viseu, Portugal.
(författare)
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Ferreira, TaniaACeS Baixo Mondego, Unidade Saude Familiar Progresso & Saude, P-3060716 Tocha, Portugal.
(författare)
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Gomes, JoanaCtr Hosp Vila Nova Gaia Espinho, Unidade 1, Serv Imunoalergol, P-4434502 Vila Nova De Gaia, Portugal.
(författare)
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Vidal, CarmenComplejo Hosp Univ Santiago, Serv Alergia, Santiago De Compostela 15706, Spain.
(författare)
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Mendes, AnaCtr Hosp Lisboa Norte, Hosp Santa Maria, Dept Pediat, P-1649035 Lisbon, Portugal.
(författare)
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Vasconcelos, Maria JoaoCtr Hosp Univ Sao Joao, Serv Imunoalergol, P-4200319 Porto, Portugal.
(författare)
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Silva, Pedro MoraisGrp HPA Saude, Imunoalergol, P-8500322 Portimao, Portugal.
(författare)
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Ferraz, JoseHosp Privado Alfena, Imunoalergol, P-4445243 Trofa Saude, Alfena, Portugal.
(författare)
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Morete, AnaHosp Infante D Pedro, Ctr Hosp Baixo Vouga, Serv Imunoalergol, P-3814501 Aveiro, Portugal.
(författare)
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Pinto, Claudia SofiaHosp Sao Pedro Vila Real, Ctr Hosp Tras Os Montes E Alto Douro, Serv Pneumol, P-5000508 Vila Real, Portugal.
(författare)
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Santos, NatachaCtr Hosp Univ Algarve, Serv Imunoalergol, P-8000386 Portimao, Portugal.
(författare)
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Loureiro, Claudia ChavesHosp Univ Coimbra, Serv Pneumol, P-3000076 Coimbra, Portugal.
(författare)
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Arrobas, AnaCtr Hosp & Univ Coimbra, Serv Pneumol, P-3000075 Coimbra, Portugal.
(författare)
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Marques, Maria LuisCtr Hosp Univ Porto, Serv Imunoalergol, P-4099001 Porto, Portugal.
(författare)
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Lozoya, CarlosHosp Amato Lusitano, Unidade Local Saude Castelo Branco, Serv Imunoalergol, P-6000085 Castelo Branco, Portugal.
(författare)
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Lopes, CristinaHosp Pedro Hispano, Serv Pediat, Unidade Local Saude Matosinhos, P-4464513 Matosinhos, Portugal.;Univ Porto, Fac Med, Imunol Basica & Clin, P-4200319 Porto, Portugal.
(författare)
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Cardia, FranciscaACES Dao Lafoes, Unidade Saude Familiar Terras Azurara, P-3530113 Mangualde, Portugal.
(författare)
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Loureiro, Carla ChavesCtr Hosp & Univ Coimbra, Dept Pediat, Serv Pediat Ambulatoria, P-3000075 Coimbra, Portugal.
(författare)
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Camara, RaquelHosp Nossa Senhora Rosario, Ctr Hosp Barreiro Montijo, Serv Pneumol, P-2834003 Barreiro, Portugal.
(författare)
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Vieira, InesACES Pinhal Litoral, UCSP Dr Arnaldo Sampaio, P-2419014 Leiria, Portugal.
(författare)
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da Silva, SofiaUSF Cuidarte, Unidade Local Saude Alto Minho, P-4925083 Portuzelo, Portugal.
(författare)
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Silva, EuricoACeS Baixo Vouga, Unidade Saude Familiar Joao Semana, P-3880225 Ovar, Portugal.
(författare)
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Rodrigues, NatalinaACES Baixo Mondego, Unidade Saude Familiar Mondego, P-3045059 Coimbra, Portugal.
(författare)
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Fonseca, Joao A.Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, P-4200319 Porto, Portugal.;Univ Porto, Dept Community Med Informat & Hlth Decis Sci MEDC, Fac Med, P-4200319 Porto, Portugal.;CUF Porto Hosp & Inst, Allergy Unit, P-4100180 Porto, Portugal.
(författare)
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Uppsala universitetPediatrisk inflammations- och metabolismforskning samt barnhälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Environmental Research and Public Health: MDPI18:31661-78271660-4601
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Till lärosätets databas
- Av författaren/redakt...
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Amaral, Rita
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Jacome, Cristina
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Almeida, Rute
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Pereira, Ana Mar ...
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Alves-Correia, M ...
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Mendes, Sandra
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visa fler...
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Rodrigues, Jose ...
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Carvalho, Joana
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Araujo, Luis
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Costa, Alberto
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Silva, Armandina
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Teixeira, Maria ...
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Ferreira-Magalha ...
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Alves, Rodrigo R ...
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Moreira, Ana Sof ...
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Fernandes, Ricar ...
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Ferreira, Rosari ...
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Pinto, Paula Lei ...
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Neuparth, Nuno
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Bordalo, Diana
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Bom, Ana Todo
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Calix, Maria Jos ...
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Ferreira, Tania
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Gomes, Joana
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Vidal, Carmen
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Mendes, Ana
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Vasconcelos, Mar ...
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Silva, Pedro Mor ...
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Ferraz, Jose
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Morete, Ana
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Pinto, Claudia S ...
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Santos, Natacha
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Loureiro, Claudi ...
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Arrobas, Ana
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Marques, Maria L ...
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Lozoya, Carlos
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Lopes, Cristina
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Cardia, Francisc ...
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Loureiro, Carla ...
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Camara, Raquel
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Vieira, Ines
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da Silva, Sofia
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Silva, Eurico
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Rodrigues, Natal ...
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Fonseca, Joao A.
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visa färre...
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