Search: id:"swepub:oai:DiVA.org:uu-438266" >
Early environmental...
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Carlsson, TorkelKarolinska Institutet
(author)
Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Cambridge University Press,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-438266
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438266URI
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https://doi.org/10.1017/S0954579420000620DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148832231URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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While neurodevelopmental disorders (NDDs) are highly heritable, several environmental risk factors have also been suggested. However, the role of familial confounding is unclear. To shed more light on this, we reviewed the evidence from twin and sibling studies. A systematic review was performed on case control and cohort studies including a twin or sibling within-pair comparison of neurodevelopmental outcomes, with environmental exposures until the sixth birthday. From 7,315 screened abstracts, 140 eligible articles were identified. After adjustment for familial confounding advanced paternal age, low birth weight, birth defects, and perinatal hypoxia and respiratory stress were associated with autism spectrum disorder (ASD), and low birth weight, gestational age and family income were associated with attention-deficit/hyperactivity disorder (ADHD), categorically and dimensionally. Several previously suspected factors, including pregnancy-related factors, were deemed due to familial confounding. Most studies were conducted in North America and Scandinavia, pointing to a global research bias. Moreover, most studies focused on ASD and ADHD. This genetically informed review showed evidence for a range of environmental factors of potential casual significance in NDDs, but also points to a critical need of more genetically informed studies of good quality in the quest of the environmental causes of NDDs.
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While neurodevelopmental disorders (NDDs) are highly heritable, several environmental risk factors have also been suggested. However, the role of familial confounding is unclear. To shed more light on this, we reviewed the evidence from twin and sibling studies. A systematic review was performed on case control and cohort studies including a twin or sibling within-pair comparison of neurodevelopmental outcomes, with environmental exposures until the sixth birthday. From 7,315 screened abstracts, 140 eligible articles were identified. After adjustment for familial confounding advanced paternal age, low birth weight, birth defects, and perinatal hypoxia and respiratory stress were associated with autism spectrum disorder (ASD), and low birth weight, gestational age and family income were associated with attention-deficit/hyperactivity disorder (ADHD), categorically and dimensionally. Several previously suspected factors, including pregnancy-related factors, were deemed due to familial confounding. Most studies were conducted in North America and Scandinavia, pointing to a global research bias. Moreover, most studies focused on ASD and ADHD. This genetically informed review showed evidence for a range of environmental factors of potential casual significance in NDDs, but also points to a critical need of more genetically informed studies of good quality in the quest of the environmental causes of NDDs.
Subject headings and genre
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Molander, Felix
(author)
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Taylor, Mark JKarolinska Institutet
(author)
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Jonsson, Ulf,1974-Karolinska Institutet,Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden;Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden(Swepub:uu)ulfjo703
(author)
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Bölte, SvenKarolinska Institutet
(author)
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Karolinska InstitutetRamklint: Barn- och ungdomspsykiatri
(creator_code:org_t)
Related titles
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In:Development and psychopathology (Print): Cambridge University Press33:4, s. 1448-14950954-57941469-2198
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