Search: (WFRF:(Spinelli John J.)) pers:(Clavel Jacqueline) pers:(Bracci Paige M) >
Genetic overlap bet...
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Din, LennoxCalif Northstate Univ, Coll Med, Elk Grove, CA USA.
(author)
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-08-13
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WILEY,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-438349
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438349URI
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https://doi.org/10.1002/gepi.22242DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145842814URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p =.0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sheikh, MohammadCalif Northstate Univ, Coll Med, Elk Grove, CA USA.
(author)
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Kosaraju, NikithaHosp Univ Penn, Dept Neurol, Ctr Neuroengn & Therapeut, 3400 Spruce St, Philadelphia, PA 19104 USA.
(author)
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Smedby, Karin EkstromKarolinska Institutet
(author)
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Bernatsky, SashaMcGill Univ, Fac Med, Montreal, PQ, Canada.;McGill Univ Hlth Ctr, Res Inst, Clin Epidemiol, Montreal, PQ, Canada.
(author)
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Berndt, Sonja, INCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Skibola, Christine F.Emory Univ, Sch Med, Atlanta, GA USA.
(author)
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Nieters, AlexandraUniv Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Germany.
(author)
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Wang, SophiaCity Hope Natl Med Ctr, Dept Populat Sci, Duarte, CA USA.;Beckman Res Inst, Duarte, CA USA.
(author)
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McKay, James D.Int Agcy Res Canc, Lyon, France.
(author)
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Cocco, PierluigiUniv Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Sardinia, Italy.
(author)
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Maynadie, MarcUniv Burgundy Franche Comte, Dijon, France.;CHU Dijon Bourgogne, Registre Hemopathies Malignes Cote Or, INSERM, U1231, Dijon, France.
(author)
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Foretova, LenkaMasaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic.
(author)
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Staines, AnthonyDublin City Univ, Sch Nursing & Human Sci, Dublin, Ireland.
(author)
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Mack, Thomas M.Univ Southern Calif, Norris Comprehens Canc Ctr & Hosp, Los Angeles, CA 90007 USA.
(author)
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de Sanjose, SilviaUniv Washington, Sch Publ Hlth, Reprod Hlth Global Program PATH, Seattle, WA 98195 USA.;Inst Catala Oncol IDIBELL, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona, Spain.;Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
(author)
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Vyse, Timothy J.Kings Coll London, Dept Med & Mol Genet, London, England.
(author)
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Padyukov, LeonidKarolinska Institutet
(author)
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Monnereau, AlainINSERM, Ctr Res Epidemiol & Stat Sorbonne CRESS, Epidemiol Childhood & Adolescent Canc Grp, Paris, France.;Inst Bergonie, Registre Hemopathies Malignes Gironde, Bordeaux, France.
(author)
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Arslan, Alan A.NYU, Sch Med, Dept Environm Med, Dept Obstet & Gynecol,Dept Populat Hlth, New York, NY USA.
(author)
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Moore, AmyNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Brooks-Wilson, Angela R.BC Canc Agcy, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada.;Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada.
(author)
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Novak, Anne J.Mayo Clin, Dept Internal Med, Rochester, MN USA.
(author)
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Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim
(author)
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Birmann, Brenda M.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
(author)
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Link, Brian K.Univ Iowa Hosp & Clin, Internal Med, Iowa City, IA 52242 USA.
(author)
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Stewart, CarolynMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
(author)
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Vajdic, Claire M.Univ New South Wales, Ctr Big Data Res Hlth, Kensington, NSW, Australia.
(author)
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Haioun, CorinneUniv Paris Est Creteil UPEC, Henri Mondor Hosp, Lymphoid Malignancies Unit, Paris, France.
(author)
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Magnani, CorradoUniversit Piemonte Orientale, Med Traslaz, Vercelli, Italy.
(author)
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Conti, David, VUniv Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA.
(author)
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Cox, David G.Ctr Rech Cancerol Lyon, Lyon, France.
(author)
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Casabonne, DelphineInst Catala Oncol IDIBELL, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona, Spain.;Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
(author)
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Albanes, DemetriusNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Kane, EleanorUniv York, Dept Hlth Sci, York, N Yorkshire, England.
(author)
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Roman, EveUniv York, Dept Hlth Sci, York, N Yorkshire, England.
(author)
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Muzi, GiacomoUniv Perugia, Dept Med, Perugia, Italy.
(author)
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Salles, GillesCtr Hosp Univ Lyon, Hematol Dept, Lyon, France.
(author)
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Giles, Graham G.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
(author)
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Adami, Hans-OlovKarolinska Institutet
(author)
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Ghesquieres, HerveCtr Hosp Univ Lyon, Hematol Dept, Lyon, France.
(author)
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De Vivo, ImmaculataBrigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
(author)
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Clavel, JacquelineINSERM, Dept Environm Epidemiol Canc, Paris, France.
(author)
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Cerhan, James R.Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
(author)
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Spinelli, John J.British Columbia Canc Agcy, Populat Oncol, Vancouver, BC, Canada.;Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
(author)
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Hofmann, JonathanNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Vijai, JosephMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
(author)
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Curtin, KarenUniv Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA.
(author)
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Costenbader, Karen H.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
(author)
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Onel, KenanUniv Chicago, Dept Pediat, Chicago, IL 60637 USA.
(author)
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Offit, KennethMem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.;Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, 1275 York Ave, New York, NY 10021 USA.
(author)
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Teras, Lauren R.Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
(author)
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Morton, LindsayNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Conde, LuciaUniv Coll London Canc Inst, Bill Lyons Informat Ctr, UCL Canc Inst, London, England.
(author)
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Miligi, LuciaInst Canc Res Prevent & Clin Network ISPRO, Environm & Occupat Epidemiol Branch, Canc Risk Factors & Lifestyle Epidemiol Unit, Florence, Italy.
(author)
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Melbye, MadsStatens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.;Stanford Univ, Sch Med, Stanford, CA 94305 USA.
(author)
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Ennas, Maria GraziaUniv Calgary, Sch Biomed Sci, Calgary, AB, Canada.
(author)
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Liebow, MarkMayo Clin, Dept Internal Med, Rochester, MN USA.
(author)
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Purdue, Mark P.NCI, Div Canc Biol, Bethesda, MD 20892 USA.
(author)
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Glenn, MarthaUniv Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA.
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Southey, Melissa C.Univ Melbourne, Dept Clin Pathol, Genet Epidemiol Lab, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Melbourne, Vic, Australia.
(author)
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Din, MorrisCalif State Univ Sacramento, Sacramento, CA 95819 USA.
(author)
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Rothman, NathanielNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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Camp, Nicola J.Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA.;Univ Utah, Dept Biomed Informat, Salt Lake City, UT USA.
(author)
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Doo, Nicole WongUniv Sydney, Concord Hosp, Clin Sch, Sydney, NSW, Australia.;Canc Council Australia, Ctr Epidemiol & Intelligence, Melbourne, Vic, Australia.
(author)
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Becker, NikolausDeutsch Krebsforschungszentrum, Div Canc Epidemiol, Heidelberg, Germany.
(author)
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Pradhan, NishaMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
(author)
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Bracci, Paige M.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
(author)
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Boffetta, PaoloIcahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
(author)
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Vineis, PaoloImperial Coll London, Sch Publ Hlth, London, England.
(author)
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Brennan, PaulInt Agcy Res Canc, Lyon, France.
(author)
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Kraft, PeterHarvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Sch Publ Hlth, Dept Biostat, Boston, MA USA.
(author)
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Lan, QingNCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Severson, Richard K.Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA.
(author)
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Vermeulen, Roel C. H.Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands.
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Milne, Roger L.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Canc Council Australia, Ctr Epidemiol & Intelligence, Melbourne, Vic, Australia.
(author)
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Kaaks, RudolphGerman Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
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Travis, Ruth C.Univ Oxford, Canc Epidemiol Unit, Oxford, England.
(author)
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Weinstein, Stephanie J.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Chanock, Stephen J.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
(author)
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Ansell, Stephen M.Mayo Clin, Dept Internal Med, Rochester, MN USA.
(author)
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Slager, Susan L.Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
(author)
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Zheng, TongzhangBrown Univ, Sch Publ Hlth, Providence, RI 02912 USA.
(author)
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Zhang, YaweiYale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA.
(author)
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Benavente, YolandaInst Catala Oncol IDIBELL, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona, Spain.;Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
(author)
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Taub, ZacharyUniv Calif Davis, Davis, CA 95616 USA.
(author)
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Madireddy, LohithUniv Calif San Francisco, Dept Neurol, San Francisco, CA USA.
(author)
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Gourraud, Pierre-AntoineUniv Nantes, Ctr Rech Transplantat & Immunol, INSERM, Ctr Hosp Univ CHU, Nantes, France.;Ctr Hosp Univ CHU Nantes, INSERM, Sante Publ, Clin Donnees, Nantes, France.
(author)
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Oksenberg, Jorge R.Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
(author)
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Cozen, WendyUniv Southern Calif, Dept Prevent Med, Norris Comprehens Canc Ctr & Hosp, Los Angeles, CA 90007 USA.;Univ Southern Calif, Norris Comprehens Canc Ctr & Hosp, Dept Pathol, Los Angeles, CA 90007 USA.
(author)
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Hjalgrim, HenrikStatens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.
(author)
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Khankhanian, PouyaHosp Univ Penn, Dept Neurol, Ctr Neuroengn & Therapeut, 3400 Spruce St, Philadelphia, PA 19104 USA.
(author)
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Calif Northstate Univ, Coll Med, Elk Grove, CA USA.Hosp Univ Penn, Dept Neurol, Ctr Neuroengn & Therapeut, 3400 Spruce St, Philadelphia, PA 19104 USA.
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In:Genetic Epidemiology: WILEY43:7, s. 844-8630741-03951098-2272
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Din, Lennox
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Sheikh, Mohammad
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Kosaraju, Nikith ...
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Smedby, Karin Ek ...
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Bernatsky, Sasha
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Berndt, Sonja, I
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Skibola, Christi ...
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Nieters, Alexand ...
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Wang, Sophia
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McKay, James D.
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Cocco, Pierluigi
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Maynadie, Marc
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Foretova, Lenka
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Staines, Anthony
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Mack, Thomas M.
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de Sanjose, Silv ...
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Vyse, Timothy J.
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Padyukov, Leonid
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Monnereau, Alain
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Arslan, Alan A.
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Moore, Amy
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Brooks-Wilson, A ...
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Novak, Anne J.
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Glimelius, Bengt
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Birmann, Brenda ...
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Link, Brian K.
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Stewart, Carolyn
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Vajdic, Claire M ...
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Haioun, Corinne
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Magnani, Corrado
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Conti, David, V
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Cox, David G.
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Casabonne, Delph ...
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Albanes, Demetri ...
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Kane, Eleanor
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Roman, Eve
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Muzi, Giacomo
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Salles, Gilles
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Giles, Graham G.
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Adami, Hans-Olov
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Ghesquieres, Her ...
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De Vivo, Immacul ...
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Clavel, Jacqueli ...
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Cerhan, James R.
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Spinelli, John J ...
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Hofmann, Jonatha ...
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Vijai, Joseph
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Curtin, Karen
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Costenbader, Kar ...
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Onel, Kenan
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Offit, Kenneth
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Teras, Lauren R.
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Morton, Lindsay
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Conde, Lucia
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Miligi, Lucia
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Melbye, Mads
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Ennas, Maria Gra ...
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Liebow, Mark
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Purdue, Mark P.
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Glenn, Martha
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Southey, Melissa ...
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Din, Morris
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Rothman, Nathani ...
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Camp, Nicola J.
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Doo, Nicole Wong
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Becker, Nikolaus
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Pradhan, Nisha
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Bracci, Paige M.
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Boffetta, Paolo
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Vineis, Paolo
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Brennan, Paul
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Kraft, Peter
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Lan, Qing
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Severson, Richar ...
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Vermeulen, Roel ...
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Milne, Roger L.
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Kaaks, Rudolph
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Travis, Ruth C.
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Weinstein, Steph ...
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Chanock, Stephen ...
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Ansell, Stephen ...
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Slager, Susan L.
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Zheng, Tongzhang
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Zhang, Yawei
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Benavente, Yolan ...
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Taub, Zachary
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Madireddy, Lohit ...
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Gourraud, Pierre ...
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Oksenberg, Jorge ...
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Cozen, Wendy
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Hjalgrim, Henrik
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Khankhanian, Pou ...
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