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Lower insulin sensi...
Lower insulin sensitivity remains a feature of children born very preterm
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- Chiavaroli, Valentina (author)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy.
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- Derraik, José G. B. (author)
- Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Univ Auckland, Better Start Natl Sci Challenge, Auckland, New Zealand.;Zhejiang Univ, Endocrinol Dept, Childrens Hosp, Sch Med, Hangzhou, Peoples R China.
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- Jayasinghe, Thilini N. (author)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.
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- Rodrigues, Raquel O. (author)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.
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- Biggs, Janene B. (author)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.
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- Battin, Malcolm (author)
- Auckland City Hosp, Newborn Serv, Auckland, New Zealand.
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- Hofman, Paul L. (author)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.
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- O'Sullivan, Justin M. (author)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.
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- Cutfield, Wayne S. (author)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Univ Auckland, Better Start Natl Sci Challenge, Auckland, New Zealand.
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Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand;Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy. Perinatal, neonatal och barnkardiologisk forskning (creator_code:org_t)
- 2020-11-06
- 2021
- English.
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In: Pediatric Diabetes. - : John Wiley & Sons. - 1399-543X .- 1399-5448. ; 22:2, s. 161-167
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The first report of children born very preterm (<32 weeks of gestation) having insulin resistance was made 16 years ago. However, neonatal care has improved since. Thus, we aimed to assess whether children born very preterm still have lower insulin sensitivity than term controls.Methods: Participants were prepubertal children aged 5 to 11 years born very preterm (<32 weeks of gestation; n = 51; 61% boys) or at term (37-41 weeks; n = 50; 62% boys). Frequently sampled intravenous glucose tolerance tests were performed, and insulin sensitivity was calculated using Bergman's minimal model. Additional clinical assessments included anthropometry, body composition using whole-body dual-energy X-ray absorptiometry scans, clinic blood pressure, and 24-hour ambulatory blood pressure monitoring.Results: Children born very preterm were 0.69 standard deviation score (SDS) lighter (P < .001), 0.53 SDS shorter (P = .003), and had body mass index 0.57 SDS lower (P = .003) than children born at term. Notably, children born very preterm had insulin sensitivity that was 25% lower than term controls (9.4 vs 12.6 x 10(-4) minutes(-1)center dot[mU/L]; P = .001). Other parameters of glucose metabolism, including fasting insulin levels, were similar in the two groups. The awake systolic blood pressure (from 24-hour monitoring) tended to be 3.1 mm Hg higher on average in children born very preterm (P = .054), while the clinic systolic blood pressure was 5.4 mm Hg higher (P = .002).Conclusions: Lower insulin sensitivity remains a feature of children born very preterm, despite improvements in neonatal intensive care. As reported in our original study, our findings suggest the defect in insulin action in prepubertal children born very pretermis primarily peripheral and not hepatic.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- children
- insulin sensitivity
- metabolism
- prematurity
Publication and Content Type
- ref (subject category)
- art (subject category)
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