Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study

Benoni, HenrikKarolinska Institutet,Uppsala universitet,Transplantationskirurgi,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden. (author)

Kidney transplant recipients (KTRs) have an increased cancer risk compared to the general population, but absolute risks that better reflect the clinical impact of cancer are seldom estimated. All KTRs in Sweden, Norway, Denmark, and Finland, with a first transplantation between 1995 and 2011, were identified through national registries. Post-transplantation cancer occurrence was assessed through linkage with cancer registries. We estimated standardized incidence ratios (SIR), absolute excess risks (AER), and cumulative incidence of cancer in the presence of competing risks. Overall, 12 984 KTRs developed 2215 cancers. The incidence rate of cancer overall was threefold increased (SIR 3.3, 95% confidence interval [CI]: 3.2-3.4). The AER of any cancer was 1560 cases (95% CI: 1468-1656) per 100 000 person-years. The highest AERs were observed for nonmelanoma skin cancer (838, 95% CI: 778-901), non-Hodgkin lymphoma (145, 95% CI: 119-174), lung cancer (126, 95% CI: 98.2-149), and kidney cancer (122, 95% CI: 98.0-149). The five- and ten-year cumulative incidence of any cancer was 8.1% (95% CI: 7.6-8.6%) and 16.8% (95% CI: 16.0-17.6%), respectively. Excess cancer risks were observed among Nordic KTRs for a wide range of cancers. Overall, 1 in 6 patients developed cancer within ten years, supporting extensive post-transplantation cancer vigilance.

Eloranta, SandraKarolinska Institutet (author)
Dahle, Dag O.Rigshosp, Oslo Univ Hosp, Dept Transplantat Med, Oslo, Norway. (author)
Svensson, My H. S.Aarhus Univ Hosp, Dept Nephrol, Aarhus, Denmark.;Akershus Univ Hosp, Med Div, Dept Nephrol, Lorenskog, Norway. (author)
Nordin, ArnoHelsinki Univ Hosp, Transplantat & Liver Surg Clin, Helsinki, Finland. (author)
Carstens, JanOdense Univ Hosp, Dept Nephrol, Odense, Denmark. (author)
Mjoen, GeirRigshosp, Oslo Univ Hosp, Dept Transplantat Med, Oslo, Norway. (author)
Helantera, IlkkaHelsinki Univ Hosp, Transplantat & Liver Surg Clin, Helsinki, Finland. (author)
Hellstrom, VivanAkademiska Univ Hosp, Dept Surg, S-75185 Uppsala, Sweden. (author)
Enblad, GunillaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)gunienbl (author)
Pukkala, EeroFinnish Canc Registry, Inst Stat & Epidemiol Canc Res, Helsinki, Finland.;Tampere Univ, Fac Social Sci, Tampere, Finland. (author)
Sorensen, Soren S.Copenhagen Univ Hosp, Rigshosp, Dept Nephrol, Copenhagen, Denmark. (author)
Lempinen, MarkoHelsinki Univ Hosp, Transplantat & Liver Surg Clin, Helsinki, Finland. (author)
Smedby, Karin E.Karolinska Institutet (author)
Uppsala universitetTransplantationskirurgi (creator_code:org_t)

By the author/editor: Benoni, Henrik; Eloranta, Sandra; Dahle, Dag O.; Svensson, My H. ...; Nordin, Arno; Carstens, Jan; show more...; Mjoen, Geir; Helantera, Ilkka; Hellstrom, Vivan; Enblad, Gunilla; Pukkala, Eero; Sorensen, Soren ...; Lempinen, Marko; Smedby, Karin E.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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