WFRF:(Meister Michael)
Sökning: WFRF:(Meister Michael) > Malignant periphera...
Malignant peripheral nerve sheath tumors in children, adolescents, and young adults : Treatment results of five Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
-
- Meister, Michael T. (författare)
- Univ Hosp Frankfurt, Dept Pediat Oncol & Hematol, Frankfurt, Germany.;German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Heidelberg, Germany.;Princess Maxima Ctr Pediat Oncol, Res, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands.
-
- Scheer, Monika (författare)
- Olga Hosp, Ctr Pediat Adolescent & Womens Med, Stuttgart Canc Ctr, Klinikum Stuttgart,Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.
-
- Hallmen, Erika (författare)
- Olga Hosp, Ctr Pediat Adolescent & Womens Med, Stuttgart Canc Ctr, Klinikum Stuttgart,Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.
- visa fler...
- visa färre...
- Univ Hosp Frankfurt, Dept Pediat Oncol & Hematol, Frankfurt, Germany;German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Heidelberg, Germany.;Princess Maxima Ctr Pediat Oncol, Res, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands. Olga Hosp, Ctr Pediat Adolescent & Womens Med, Stuttgart Canc Ctr, Klinikum Stuttgart,Pediat Oncol Hematol Immunol 5, Stuttgart, Germany. (creator_code:org_t)
- 2020-08-18
- 2020
- Engelska.
- Ingår i: Journal of Surgical Oncology. - : WILEY. - 0022-4790 .- 1096-9098. ; 122:7, s. 1337-1347
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background and Objectives Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that present as large, invasive tumors. Our aim was to assess outcomes, identify prognostic factors, and analyze treatment strategies in a prospectively collected pediatric cohort. Methods Patients less than 21 years with MPNST treated in the consecutive prospective European Cooperative Weichteilsarkom Studiengruppe (CWS)-trials (1981-2009) and the CWS-SoTiSaR registry (2009-2015) were analyzed. Results A total of 159 patients were analyzed. Neurofibromatosis type I (NF1) was reported in thirty-eight patients (24%). Most were adolescents (67%) with large (>10 cm, 65%) tumors located at extremities (42%). Nodal involvement was documented in 15 (9%) and distant metastases in 15 (9%) upon diagnosis. Overall, event-free survival (EFS) was 40.5% at 5 and 36.3% at 10 years, and overall survival (OS) was 54.6% at 5 and 47.1% at 10 years. Age, NF1 status, tumor site, tumor size, Intergroup Rhabdomyosarcoma Study (IRS) group, metastatic disease, and achieving first complete remission (CR1) were identified as prognostic factors for EFS and/or OS in the univariate analysis. Conclusions Prognostic factors were identified and research questions for future clinical trials were addressed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- malignant peripheral nerve sheath tumor
- metastatic sarcoma
- neurofibromatosis
- pediatric sarcoma
- soft tissue sarcoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
- Journal of Surgical Oncology (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Meister, Michael ...
- Scheer, Monika
- Hallmen, Erika
- Stegmaier, Sabin ...
- Vokuhl, Christia ...
- von Kalle, Thekl ...
- visa fler...
- Fuchs, Joerg
- Muenter, Marc
- Niggli, Felix
- Ladenstein, Ruth
- Kazanowska, Bern ...
- Ljungman, Gustaf ...
- Bielack, Stefan
- Koscielniak, Ewa
- Klingebiel, Thom ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- Journal of Surgi ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
