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p53 is associated w...
p53 is associated with high-risk and pinpointsTP53missense mutations in mantle cell lymphoma
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- Rodrigues, Joana M. (författare)
- Lund Univ, Dept Immunotechnol, Medicon Village 406,Scheelevagen 8, S-22387 Lund, Sweden.
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- Hassan, May (författare)
- Lund Univ, Dept Immunotechnol, Medicon Village 406,Scheelevagen 8, S-22387 Lund, Sweden.
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- Freiburghaus, Catja (författare)
- Lund Univ, Dept Immunotechnol, Medicon Village 406,Scheelevagen 8, S-22387 Lund, Sweden.
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- Eskelund, Christian W. (författare)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.;Univ Copenhagen, Biotech Res & Innovat Ctr BRIC, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Danish Stem Cell Ctr Danstem, Copenhagen, Denmark.
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- Geisler, Christian (författare)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.
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- Raty, Riikka (författare)
- Helsinki Univ Hosp, Dept Haematol, Helsinki, Finland.
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- Kolstad, Arne (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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- Sundström, Christer (författare)
- Uppsala universitet,Klinisk och experimentell patologi
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- Glimelius, Ingrid, 1975- (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Gronbaek, Kirsten (författare)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.;Univ Copenhagen, Biotech Res & Innovat Ctr BRIC, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Danish Stem Cell Ctr Danstem, Copenhagen, Denmark.
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- Kwiecinska, Anna (författare)
- Karolinska Inst, Dept Pathol Oncol, Stockholm, Sweden.
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- Porwit, Anna (författare)
- Lund Univ, Dept Pathol, Lund, Sweden.
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- Jerkeman, Mats (författare)
- Lund Univ, Dept Oncol, Lund, Sweden.
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- Ek, Sara (författare)
- Lund Univ, Dept Immunotechnol, Medicon Village 406,Scheelevagen 8, S-22387 Lund, Sweden.
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Lund Univ, Dept Immunotechnol, Medicon Village 406,Scheelevagen 8, S-22387 Lund, Sweden Rigshosp, Dept Haematol, Copenhagen, Denmark.;Univ Copenhagen, Biotech Res & Innovat Ctr BRIC, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Danish Stem Cell Ctr Danstem, Copenhagen, Denmark. (creator_code:org_t)
- 2020-08-04
- 2020
- Engelska.
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Ingår i: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141. ; 191:5, s. 796-805
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Ämnesord
Stäng
- Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely implemented in clinical practice for MCL, and immunohistochemistry (IHC) is a feasible alternative to identify high-risk patients. The aim of the present study was to investigate the accuracy of p53 as a tool to identify patients withTP53missense mutations and the prognostic impact of overexpression and mutations in a Swedish population-based cohort. In total, 317 cases were investigated using IHC and 255 cases were sequenced, enabling analysis of p53 andTP53status among 137 cases divided over the two-cohort investigated. The accuracy of predicting missense mutations from protein expression was 82%, with sensitivity at 82% and specificity at 100% in paired samples. We further show the impact of p53 expression andTP53mutations on survival (hazard ratio of 3 center dot 1 in univariate analysis for both), and the association to risk factors, such as high MCL International Prognostic Index, blastoid morphology and proliferation, in a population-based setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- immunohistochemistry
- p53
- <styled-content style="text-decoration
- underline">TP53
- mantle cell lymphoma
- digital pathology
- targeted sequencing
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- ref (ämneskategori)
- art (ämneskategori)
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Rodrigues, Joana ...
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Hassan, May
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Freiburghaus, Ca ...
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Eskelund, Christ ...
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Geisler, Christi ...
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Raty, Riikka
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Kolstad, Arne
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Sundström, Chris ...
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Glimelius, Ingri ...
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Gronbaek, Kirste ...
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Kwiecinska, Anna
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Porwit, Anna
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Jerkeman, Mats
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Ek, Sara
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