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Evaluation of the s...
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Dahl, OlavHaukeland Hosp, Dept Oncol, Bergen, Norway; Univ Bergen, Med Fac, Dept Clin Sci, Bergen, Norway
(författare)
Evaluation of the stage classification of anal cancer by the TNM 8th version versus the TNM 7th version
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-439515
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-439515URI
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https://doi.org/10.1080/0284186X.2020.1778180DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages.Patients and methods: The Nordic Anal Cancer Group (NOAC) conducted a large retrospective study of all anal cancers in Norway, Sweden and most of Denmark in 2000–2007. From the Nordic cohort 1151 anal cancer patients with follow-up data were classified by the TNM 4th edition which has identical T, N and M definitions as the TNM 7th edition, and therefore also can be classified by the TNM 7th stage groups. We used the Nordic cohort to translate the T, N and M stages into the TNM 8th stages and sub-stages. Overall survival for each stage was assessed.Results: Although the summary stage groups for TNM 8th edition discriminates patients with different prognosis reasonably well, the analyses of the seven sub-stages show overlapping overall survival: HR for stage IIA 1.30 (95%CI 0.80–2.12) is not significantly different from stage I (p = .30) and HR for stage IIB 2.35 (95%CI 1.40–3.95) and IIIA 2.48 (95%CI 1.43–4.31) are also similar as were HRs for stage IIIB 3.41 (95%CI 1.99–5.85) and IIIC 3.22 (95%CI 1.99–5.20). Similar overlapping was shown for local recurrence and distant spread.Conclusion: The results for the sub-stages calls for a revision of the staging system. We propose a modification of the TNM 8th edition for staging of anal cancer into four stages based on the T, N and M definitions of the TNM 8th classification.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Myklebust, Mette PernilleHaukeland Hosp, Dept Oncol, Bergen, Norway
(författare)
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Dale, Jon EspenHaukeland Hosp, Dept Oncol, Bergen, Norway
(författare)
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Leon, OtiliaSkåne Univ Hosp, Dept Oncol, Lund, Sweden
(författare)
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Serup-Hansen, EvaUniv Copenhagen, Herlev Hosp, Dept Oncol, Copenhagen, Denmark
(författare)
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Jakobsen, AndersUniv Southern Denmark, Vejle Hosp, Dept Oncol, Vejle, Denmark
(författare)
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Pfeiffer, PerUniv Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Oncol, Odense C, Denmark
(författare)
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Løes, Inger MarieHaukeland Hosp, Dept Oncol, Bergen, Norway
(författare)
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Pfeffer, FrankHaukeland Hosp, Dept Gastroenterol Surg, Bergen, Norway; Univ Bergen, Dept Clin Med, Bergen, Norway
(författare)
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Garm Spindler, Karen-LiseAarhus Univ Hosp, Dept Expt Clin Oncol, Aarhus, Denmark; Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark
(författare)
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Grønlie Guren, MarianneOslo Univ Hosp, Dept Oncol, Oslo, Norway; Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway
(författare)
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Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim
(författare)
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Johnsson, AndersSkåne Univ Hosp, Dept Oncol, Lund, Sweden
(författare)
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Haukeland Hosp, Dept Oncol, Bergen, Norway; Univ Bergen, Med Fac, Dept Clin Sci, Bergen, NorwayHaukeland Hosp, Dept Oncol, Bergen, Norway
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Oncologica59:9, s. 1016-10230284-186X1651-226X
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Dahl, Olav
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Myklebust, Mette ...
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Dale, Jon Espen
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Leon, Otilia
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Serup-Hansen, Ev ...
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Jakobsen, Anders
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visa fler...
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Pfeiffer, Per
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Løes, Inger Mari ...
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Pfeffer, Frank
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Garm Spindler, K ...
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Grønlie Guren, M ...
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Glimelius, Bengt
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Johnsson, Anders
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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