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Evaluation of the s...
Evaluation of the stage classification of anal cancer by the TNM 8th version versus the TNM 7th version
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- Dahl, Olav (author)
- Haukeland Hosp, Dept Oncol, Bergen, Norway; Univ Bergen, Med Fac, Dept Clin Sci, Bergen, Norway
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- Myklebust, Mette Pernille (author)
- Haukeland Hosp, Dept Oncol, Bergen, Norway
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- Dale, Jon Espen (author)
- Haukeland Hosp, Dept Oncol, Bergen, Norway
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- Leon, Otilia (author)
- Skåne Univ Hosp, Dept Oncol, Lund, Sweden
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- Serup-Hansen, Eva (author)
- Univ Copenhagen, Herlev Hosp, Dept Oncol, Copenhagen, Denmark
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- Jakobsen, Anders (author)
- Univ Southern Denmark, Vejle Hosp, Dept Oncol, Vejle, Denmark
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- Pfeiffer, Per (author)
- Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Oncol, Odense C, Denmark
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- Løes, Inger Marie (author)
- Haukeland Hosp, Dept Oncol, Bergen, Norway
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- Pfeffer, Frank (author)
- Haukeland Hosp, Dept Gastroenterol Surg, Bergen, Norway; Univ Bergen, Dept Clin Med, Bergen, Norway
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- Garm Spindler, Karen-Lise (author)
- Aarhus Univ Hosp, Dept Expt Clin Oncol, Aarhus, Denmark; Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark
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- Grønlie Guren, Marianne (author)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway; Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway
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- Glimelius, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Johnsson, Anders (author)
- Skåne Univ Hosp, Dept Oncol, Lund, Sweden
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: Acta Oncologica. - 0284-186X .- 1651-226X. ; 59:9, s. 1016-1023
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages.Patients and methods: The Nordic Anal Cancer Group (NOAC) conducted a large retrospective study of all anal cancers in Norway, Sweden and most of Denmark in 2000–2007. From the Nordic cohort 1151 anal cancer patients with follow-up data were classified by the TNM 4th edition which has identical T, N and M definitions as the TNM 7th edition, and therefore also can be classified by the TNM 7th stage groups. We used the Nordic cohort to translate the T, N and M stages into the TNM 8th stages and sub-stages. Overall survival for each stage was assessed.Results: Although the summary stage groups for TNM 8th edition discriminates patients with different prognosis reasonably well, the analyses of the seven sub-stages show overlapping overall survival: HR for stage IIA 1.30 (95%CI 0.80–2.12) is not significantly different from stage I (p = .30) and HR for stage IIB 2.35 (95%CI 1.40–3.95) and IIIA 2.48 (95%CI 1.43–4.31) are also similar as were HRs for stage IIIB 3.41 (95%CI 1.99–5.85) and IIIC 3.22 (95%CI 1.99–5.20). Similar overlapping was shown for local recurrence and distant spread.Conclusion: The results for the sub-stages calls for a revision of the staging system. We propose a modification of the TNM 8th edition for staging of anal cancer into four stages based on the T, N and M definitions of the TNM 8th classification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Dahl, Olav
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Myklebust, Mette ...
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Dale, Jon Espen
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Leon, Otilia
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Serup-Hansen, Ev ...
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Jakobsen, Anders
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Pfeiffer, Per
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Løes, Inger Mari ...
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Pfeffer, Frank
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Garm Spindler, K ...
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Grønlie Guren, M ...
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Glimelius, Bengt
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Johnsson, Anders
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Acta Oncologica
- By the university
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Uppsala University