Sökning: WFRF:(Dahl Inger Marie) >
Evaluation of the s...
Evaluation of the stage classification of anal cancer by the TNM 8th version versus the TNM 7th version
-
- Dahl, Olav (författare)
- Haukeland Hosp, Dept Oncol, Bergen, Norway; Univ Bergen, Med Fac, Dept Clin Sci, Bergen, Norway
-
- Myklebust, Mette Pernille (författare)
- Haukeland Hosp, Dept Oncol, Bergen, Norway
-
- Dale, Jon Espen (författare)
- Haukeland Hosp, Dept Oncol, Bergen, Norway
-
visa fler...
-
- Leon, Otilia (författare)
- Skåne Univ Hosp, Dept Oncol, Lund, Sweden
-
- Serup-Hansen, Eva (författare)
- Univ Copenhagen, Herlev Hosp, Dept Oncol, Copenhagen, Denmark
-
- Jakobsen, Anders (författare)
- Univ Southern Denmark, Vejle Hosp, Dept Oncol, Vejle, Denmark
-
- Pfeiffer, Per (författare)
- Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Oncol, Odense C, Denmark
-
- Løes, Inger Marie (författare)
- Haukeland Hosp, Dept Oncol, Bergen, Norway
-
- Pfeffer, Frank (författare)
- Haukeland Hosp, Dept Gastroenterol Surg, Bergen, Norway; Univ Bergen, Dept Clin Med, Bergen, Norway
-
- Garm Spindler, Karen-Lise (författare)
- Aarhus Univ Hosp, Dept Expt Clin Oncol, Aarhus, Denmark; Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark
-
- Grønlie Guren, Marianne (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway; Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway
-
- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
-
- Johnsson, Anders (författare)
- Skåne Univ Hosp, Dept Oncol, Lund, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2020
- 2020
- Engelska.
-
Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 59:9, s. 1016-1023
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages.Patients and methods: The Nordic Anal Cancer Group (NOAC) conducted a large retrospective study of all anal cancers in Norway, Sweden and most of Denmark in 2000–2007. From the Nordic cohort 1151 anal cancer patients with follow-up data were classified by the TNM 4th edition which has identical T, N and M definitions as the TNM 7th edition, and therefore also can be classified by the TNM 7th stage groups. We used the Nordic cohort to translate the T, N and M stages into the TNM 8th stages and sub-stages. Overall survival for each stage was assessed.Results: Although the summary stage groups for TNM 8th edition discriminates patients with different prognosis reasonably well, the analyses of the seven sub-stages show overlapping overall survival: HR for stage IIA 1.30 (95%CI 0.80–2.12) is not significantly different from stage I (p = .30) and HR for stage IIB 2.35 (95%CI 1.40–3.95) and IIIA 2.48 (95%CI 1.43–4.31) are also similar as were HRs for stage IIIB 3.41 (95%CI 1.99–5.85) and IIIC 3.22 (95%CI 1.99–5.20). Similar overlapping was shown for local recurrence and distant spread.Conclusion: The results for the sub-stages calls for a revision of the staging system. We propose a modification of the TNM 8th edition for staging of anal cancer into four stages based on the T, N and M definitions of the TNM 8th classification.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Dahl, Olav
-
Myklebust, Mette ...
-
Dale, Jon Espen
-
Leon, Otilia
-
Serup-Hansen, Ev ...
-
Jakobsen, Anders
-
visa fler...
-
Pfeiffer, Per
-
Løes, Inger Mari ...
-
Pfeffer, Frank
-
Garm Spindler, K ...
-
Grønlie Guren, M ...
-
Glimelius, Bengt
-
Johnsson, Anders
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Acta Oncologica
- Av lärosätet
-
Uppsala universitet