Super enhancers-Functional cores under the 3D genome

Zhang, JuqingNorthwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China. (författare)

Complex biochemical reactions take place in the nucleus all the time. Transcription machines must follow the rules. The chromatin state, especially the three-dimensional structure of the genome, plays an important role in gene regulation and expression. The super enhancers are important for defining cell identity in mammalian developmental processes and human diseases. It has been shown that the major components of transcriptional activation complexes are recruited by super enhancer to form phase-separated condensates. We summarize the current knowledge about super enhancer in the 3D genome. Furthermore, a new related transcriptional regulation model from super enhancer is outlined to explain its role in the mammalian cell progress.

Yue, WeiNorthwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China. (författare)
Zhou, YaqiNorthwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China. (författare)
Liao, MingzhiNorthwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China. (författare)
Chen, XingqiUppsala universitet,Molekylära verktyg(Swepub:uu)xinch196 (författare)
Hua, JinlianNorthwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China. (författare)
Northwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China.Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China. (creator_code:org_t)

Av författaren/redakt...: Zhang, Juqing; Yue, Wei; Zhou, Yaqi; Liao, Mingzhi; Chen, Xingqi; Hua, Jinlian

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