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Melflufen for relap...
Melflufen for relapsed and refractory multiple myeloma
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- Oriol, Albert (författare)
- Hosp Badalona Germans Trias & Pujol, Inst Josep Carreras, Badalona, Spain.;Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Badalona, Spain.
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- Larocca, Alessandra (författare)
- Univ Torino, Azienda Osped Univ Citta Salute & Sci Torino, Turin, Italy.
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- Leleu, Xavier (författare)
- CHU Poitiers, Hop De La Miletrie, Dept Hematol, Poitiers, France.
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- Hajek, Roman (författare)
- Univ Ostrava, Dept Hematooncol, Ostrava, Czech Republic.;Univ Ostrava, Fac Med, Ostrava, Czech Republic.
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- Hassoun, Hani (författare)
- Mem Sloan Kettering Canc Ctr, Dept Med, Myeloma Serv, 1275 York Ave, New York, NY 10021 USA.
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- Rodriguez-Otero, Paula (författare)
- Clin Univ Navarra, Dept Hematol, Pamplona, Spain.
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- Paner, Agne (författare)
- Rush Univ, Med Ctr, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60612 USA.
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- Schjesvold, Fredrik H. (författare)
- Univ Oslo, Oslo Univ Hosp, Oslo Myeloma Ctr, Oslo, Norway.;Univ Oslo, KG Jebsen Ctr BCell Malignancies, Oslo, Norway.
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- Gullbo, Joachim (författare)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin
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- Richardson, Paul G. (författare)
- Harvard Med Sch, Jerome Lipper Multiple Myeloma Ctr, Dana Farber Canc Inst, Boston, MA 02115 USA.
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Hosp Badalona Germans Trias & Pujol, Inst Josep Carreras, Badalona, Spain;Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Badalona, Spain. Univ Torino, Azienda Osped Univ Citta Salute & Sci Torino, Turin, Italy. (creator_code:org_t)
- 2020-09-29
- 2020
- Engelska.
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Ingår i: Expert Opinion on Investigational Drugs. - : TAYLOR & FRANCIS LTD. - 1354-3784 .- 1744-7658. ; 29:10, s. 1069-1078
- Relaterad länk:
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: The overall survival of patients with multiple myeloma has improved with the advent of novel agents; however, multiple myeloma remains incurable. Combinations of standard-of-care agents such as immunomodulators, proteasome inhibitors, and anti-CD38 monoclonal antibodies are increasingly used in earlier lines of therapy. Patients with disease that is refractory to multiple novel agents represent a population with high unmet medical need and for whom therapies with new mechanisms of action could be beneficial. Melphalan flufenamide (melflufen) has demonstrated encouraging activity in patients with relapsed and refractory multiple myeloma. Areas covered: This review provides an overview of the mechanism of action of melflufen, a first-in-class peptide-drug conjugate that targets aminopeptidases and rapidly delivers alkylating agents into tumor cells. It reviews key Phase I and II clinical trial data for melflufen in combination with dexamethasone as well as in triplet combinations with daratumumab or bortezomib. The safety profile of melflufen, which is characterized primarily by clinically manageable hematologic adverse events, is described. Expert opinion: Melflufen has potential to fill a gap in the myeloma treatment landscape by providing a new mechanism of action with clinically meaningful efficacy and a favorable safety profile in patients refractory to multiple novel agents.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Melflufen
- melphalan flufenamide
- relapsed
- refractory multiple myeloma
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Oriol, Albert
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Larocca, Alessan ...
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Leleu, Xavier
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Hajek, Roman
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Hassoun, Hani
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Rodriguez-Otero, ...
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Paner, Agne
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Schjesvold, Fred ...
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Gullbo, Joachim
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Richardson, Paul ...
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