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Mono-(2-ethylhexyl)...
Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses
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- Lin, Chun-Yu (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Anestesiologi och intensivvård,Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med,Grad Inst Med, Kaohsiung, Taiwan
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- Huang, Chung-Hao (author)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
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- Wang, Wen-Hung (author)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
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- Tenhunen, Jyrki (author)
- Uppsala universitet,Anestesiologi och intensivvård,Institutionen för medicinsk biokemi och mikrobiologi
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- Hung, Ling-Chien (author)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
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- Lin, Chi-Chou (author)
- Kaohsiung Med Univ, Coll Biomed Sci, Dept Biotechnol, Kaohsiung, Taiwan
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- Chen, Yu-Cheng (author)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
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- Chen, Yen-Hsu (author)
- Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan; Kaohsiung Municipal Tatung Hosp, Dept Internal Med, Kaohsiung, Taiwan; Natl Chiao Tung Univ, Coll Biol Sci & Technol, Dept Biol Sci & Technol, Hsinchu, Taiwan
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- Liao, Wei-Ting (author)
- Kaohsiung Med Univ, Coll Biomed Sci, Dept Biotechnol, Kaohsiung, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan; Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan
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(creator_code:org_t)
- 2021-02-15
- 2021
- English.
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In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 12
- Related links:
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Abstract
Subject headings
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- Exposure to environmental hormones such as di(2-ethylhexyl) phthalate (DEHP) has become a critical human health issue globally. This study aimed to investigate the correlations between DEHP/mono-(2-ethylhexyl) phthalate (MEHP) levels and macrophage-associated immune responses and clinical manifestations in dengue virus (DV)-infected patients. Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. MEHP-treated MDMs had lower antiviral Th17 response induction activity in mixed T-cell response tests. The in vitro data showed that MEHP increased DV viral load and decreased IL-23 release dose-dependently, and adding IL-23 to MEHP-exposed MDMs significantly reduced the DV viral load. MEHP also suppressed IL-23 expression via the peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. Further, the PPAR-γ antagonist GW9662 significantly reversed MEHP-induced IL-23 suppression and reduced the DV viral load. These study findings help to explain the associations between high MEHP levels and the high global burden of dengue disease.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- phthalate
- dengue virus
- macrophage
- IL-23
- biological sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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